1
John Wallace Parce, Anne R Kopf Sill, Luc J Bousse: High throughput screening assay systems in microscale fluidic devices. Caliper Technologies Corporation, Matthew B Murphy, Jonathan Alan Quine, Townsend and Townsend and Crew, August 24, 1999: US05942443 (552 worldwide citation)

Microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.


2
Anne R Kopf Sill, John Wallace Parce: Microfluidic systems incorporating varied channel dimensions. Caliper Technologies Corporation, Matthew B Murphy, December 1, 1998: US05842787 (466 worldwide citation)

The present invention is generally directed to improved microfluidic devices, systems and methods of using same, which incorporate channel profiles that impart significant benefits over previously described systems. In particular, the presently described devices and systems employ channels having, a ...


3
J Wallace Parce, Anne R Kopf Sill, Luc J Bousse: High throughput screening assay systems in microscale fluidic devices. Caliper Technologies Corporation, Matthew B Murphy, Jonathan Alan Quine, Townsend and Townsend and Crew, April 4, 2000: US06046056 (437 worldwide citation)

The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and ...


4
Tammy Burd Mehta, Anne R Kopf Sill, J Wallace Parce, Andrea W Chow, Luc J Bousse, Michael R Knapp, Theo T Nikiforov, Steve Gallagher: Manipulation of microparticles in microfluidic systems. Caliper Technologies, Matthew B Murphy, Donald R McKenna, Quine Intellectual Property Law Group P C, October 14, 2003: US06632655 (371 worldwide citation)

Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus and integrated systems comprising arrays and a ...


5
John Wallace Parce, Anne R Kopf Sill: Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems. Caliper Technologies, Matthew B Murphy, February 9, 1999: US05869004 (272 worldwide citation)

The present invention is generally directed to methods, apparatus and systems for use in performing in situ dilution or concentration of a particular subject material in a microfluidic device or system. These methods and apparatus may generally be integrated with other microfluidic operations and/or ...


6

7
Michael Knapp, John Wallace Parce, Luc J Bousse, Anne R Kopf Sill: Closed-loop biochemical analyzers. Caliper Technologies, Jonathan Alan Quine, Matthew B Murphy, Law Offices of Jonathan Alan Quine, May 22, 2001: US06235471 (227 worldwide citation)

Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and ...


8
Michael Knapp, John Wallace Parce, Luc J Bousse, Anne R Kopf Sill: Microfluidic devices and methods for separation. Caliper Technologies, Matthew B Murphy, Angela P Horne, Quine Intellectual Property Law Group P C, September 3, 2002: US06444461 (223 worldwide citation)

Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and ...


9
H Garrett Wada, Anne R Kopf Sill, Marja Liisa Alajoki, J Wallace Parce, Benjamin N Wang, Andrea W Chow, Robert S Dubrow, Yevgeny Yurkovetsky, Javier Anibal Farinas: Focusing of microparticles in microfluidic systems. Caliper Technologies, Andrew L Filler, Quine Intellectual Property Law Group, July 15, 2003: US06592821 (212 worldwide citation)

Methods and systems for particle focusing to increase assay throughput and sensitivity in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations ...


10
J Wallace Parce, Theo T Nikiforov, Tammy Burd Mehta, Anne R Kopf Sill, Andrea W Chow, Michael R Knapp: Sequencing by incorporation. Caliper Technologies, Stacy Landry, Gary Baker, Quine Intellectual Property Law Group P C, September 2, 2003: US06613513 (192 worldwide citation)

Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking groups include phosphate groups and carb ...