1
Balkrishen Bhat, Neelima Bhat, Anne B Eldrup, Thazha P Prakash, Marija Prhavc, Quanlai Song, Phillip Dan Cook, Steven S Carroll, Malcolm Maccoss, David B Olsen: Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase of hepatitis C virus. Merck & Co, Isis Pharmaceuticals, Philippe L Durette, Melvin Winokur, August 17, 2004: US06777395 (141 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


2
Steven S Carroll, David B Olsen, Malcolm MacCoss, Balkrishen Bhat, Phillip Dan Cook, Anne B Eldrup, Thazha P Prakash: Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. Merck & Co, Isis Pharmaceuticals, Philippe L Durette, Melvin Winokur, September 12, 2006: US07105499 (105 worldwide citation)

The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of ...


3
Balkrishen Bhat, Neelima Bhat, Anne B Eldrup, Thazha P Prakash, Marija Prhavc, Quanlai Song, Phillip Dan Cook, Steven S Carroll, Malcolm Maccoss, David B Olsen: Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. Merck & Co, Philippe L Durette, Melvin Winokur, October 24, 2006: US07125855 (103 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


4
Anne B Eldrup, Marija Prhavc, Phillip Dan Cook, Steven S Carroll, David B Olsen: Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. Merck & Co, ISIS Pharmaceuticals, Philippe L Durette, Melvin Winokur, April 10, 2007: US07202224 (96 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


5
David B Olsen, Robert L LaFemina, Anne B Eldrup, Sanjib Bera: Methods of inhibiting orthopoxvirus replication with nucleoside compounds. Merck & Co, Isis Pharmaceuticals, Kenneth R Walton, Philippe L Durette, Sheldon O Heber, January 29, 2008: US07323453 (36 worldwide citation)

The present invention provides methods of inhibiting orthopoxvirus replication and/or treating orthopoxvirus infection with certain nucleoside compounds and derivatives thereof. These compounds are particularly useful as inhibitors of vaccinia virus and variola virus replication and/or for the treat ...


6
Gabor Butora, Malcolm MacCoss, Balkrishen Bhat, Anne B Eldrup: C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase. Merck & Co, Kenneth R Walton, Sheldon O Heber, Philippe L Durette, May 19, 2009: US07534767 (13 worldwide citation)

The present invention provides C-purine nucleoside analogs and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are pa ...


7
Thazha P Prakash, Brenda F Baker, Anne B Eldrup, Muthiah Manoharan, Balkrishen Bhat, Richard Griffey, Eric E Swayze, Stanley T Crooke: 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations. Isis Pharmaceuticals, ISIS Patent Department, October 12, 2010: US07812149 (6 worldwide citation)

Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucl ...


8
Brenda F Baker, Anne B Eldrup, Muthiah Manoharan, Balkrishen Bhat, Richard Griffey, Eric E Swayze, Stanley T Crooke, Thazha P Prakash: 2′-substituted oligomeric compounds and compositions for use in gene modulations. Isis Pharmaceuticals, Isis Patent Department, April 5, 2011: US07919612 (5 worldwide citation)

Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucl ...


9
Charles Allerson, Balkrishen Bhat, Anne B Eldrup, Muthiah Manoharan, Richard H Griffey, Brenda F Baker, Eric E Swayze: Compositions comprising alternating 2′-modified nucleosides for use in gene modulation. Isis Pharmaceuticals, Isis Pharmaceuticals Patent Dept, December 10, 2013: US08604183 (4 worldwide citation)

The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression ...


10
Balkrishen Bhat, Anne B Eldrup, Thazha P Prakash, Phillip Dan Cook, Robert L LaFemina, Amy L Simcoe, Carrie A Rutkowski, Mario A Valenciano: Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. Merck Sharp & Dohme, ISIS Pharmaceuticals, Sheldon O Heber, Jeffrey P Bergman, July 9, 2013: US08481712 (3 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...