1
Richard B Greenwald, Annapurna Pendri: High molecular weight polymer-based prodrugs. Enzon, Michael N Mercanti, March 25, 1997: US05614549 (150 worldwide citation)

Water-soluble prodrugs of the formula: ##STR1## wherein: D is a biologically active nucleophile;


2
Richard B Greenwald, Annapurna Pendri: High molecular weight polymer-based prodrugs. Enzon, Roberts & Mercanti L, November 24, 1998: US05840900 (115 worldwide citation)

The present invention is directed compositions of the formula: ##STR1## wherein: D is a biologically active moiety;


3
Richard B Greenwald, Annapurna Pendri: High molecular weight polymer-based prodrugs. Enzon, Roberts & Mercanti, March 9, 1999: US05880131 (101 worldwide citation)

High molecular weight, water-soluble prodrugs of the formula: ##STR1## wherein: D is a biologically active moiety;


4
Richard B Greenwald, Annapurna Pendri: Taxane-based prodrugs. Enzon, Roberts & Mercanti, October 20, 1998: US05824701 (84 worldwide citation)

Taxane-based compositions of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of aryls, substituted aryls, aralkyls, substituted aralkyls, alkyls and substituted alkyls;


5
Richard B Greenwald, Annapurna Pendri, Hong Zhao: High molecular weight polymer-based prodrugs. Enzon, Roberts & Mercanti, October 3, 2000: US06127355 (78 worldwide citation)

The present invention is directed compositions of the formula: ##STR1## wherein: D is a residue of a biologically active moiety;


6
Anthony J Martinez, Annapurna Pendri, Richard B Greenwald, Yun H Choe: Terminally-branched polymeric linkers and polymeric conjugates containing the same. Enzon, Roberts & Mercanti, November 28, 2000: US06153655 (77 worldwide citation)

The present invention is directed to polymeric- prodrug transport forms of the formula: ##STR1## wherein: B is a leaving group, OH, a residue of a hydroxyl-containing moiety or ##STR2## wherein B.sub.1 is a leaving group, OH or a residue of a hydroxyl-containing moiety;


7
Richard B Greenwald, Annapurna Pendri, Yun H Choe: Acyl polymeric derivatives of aromatic hydroxyl-containing compounds. Enzon, Roberts & Mercanti L, January 4, 2000: US06011042 (72 worldwide citation)

The present invention is directed to conjugates such as polymeric prodrugs of aromatic, hydroxyl-containing compounds and methods of making and using the same. These polymeric prodrugs are preferably esters of hydroxyl-containing aromatic compounds and are formed by reacting a desired aromatic, hydr ...


8
Richard B Greenwald, Annapurna Pendri, Hong Zhao: High molecular weight polymer-based prodrugs. Enzon, Roberts & Mercanti L, October 12, 1999: US05965566 (69 worldwide citation)

The present invention is directed compositions of the formula: ##STR1## wherein: D is a residue of biologically active moiety;


9
Richard B Greenwald, Annapurna Pendri, Yun H Choe: Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents. Enzon, Roberts & Mercanti, January 30, 2001: US06180095 (64 worldwide citation)

The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric prodrugs are preferably of the formula:


10
Richard B Greenwald, Yun H Choe, Annapurna Pendri: Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents. Enzon, Roberts & Mercanti L, October 16, 2001: US06303569 (61 worldwide citation)

The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric compounds comprise the formula: