1
Essa Hu, Jason Brooks Human, Roxanne Kunz, Andrew Tasker, Ryan White: Substituted pyridone compounds and methods of use. G Prabhakar Reddy, April 20, 2010: US07700607 (47 worldwide citation)

The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various inflammatory, fibrotic and/or mast cell mediated diseases such as mastocytosis. The compounds have a general Formula ...


2
Dawei Zhang, Andrew Tasker, Kelvin K C Sham, Partha Pratim Chakrabarti, James Richard Falsey, Bradley J Herberich, Liping H Pettus, Robert M Rzasa: Imidazo- and triazolo-pyridine compounds and methods of use thereof. Amgen, G Prabhakar Reddy, April 20, 2010: US07700593 (16 worldwide citation)

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A, B, R1, R2, R3 and R4 are defined herein. The invention also comprise ...


3
Guoqing Chen, Jeffrey Adams, Jean Bemis, Shon Booker, Guolin Cai, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Stephanie Geuns Meyer, Michael Handley, Qi Huang, Joseph L Kim, Tae Seong Kim, Alexander Kiselyov, Xiaohu Ouyang, Vinod F Patel, Leon M Smith, Markian Stec, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael Croghan: Substituted alkylamine derivatives and methods of use. Amgen, Joseph W Bulock, February 7, 2006: US06995162 (13 worldwide citation)

Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis a ...


4
Tae Seong Kim, Steven Bellon, Shon Booker, Noel D Angelo, Celia Dominguez, Ingrid Fellows, Matthew Lee, Longbin Liu, Elizabeth Rainbeau, Aaron C Siegmund, Andrew Tasker, Ning Xi, Yuan Cheng: Substituted heterocycles and methods of use. Amgem, January 26, 2010: US07652009 (12 worldwide citation)

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and ...


5
Guoqing Chen, Jeffrey Adams, Jean Bemis, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Qi Huang, Joseph L Kim, Xiaohu Ouyang, Vinod F Patel, Leon M Smith, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael Croghan, Tae Seong Kim: Substituted amine derivatives and methods of use. Amgen, Joseph W Bulock, September 12, 2006: US07105682 (10 worldwide citation)

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseas ...


6
Michele Potashman, Tae Seong Kim, Steven Bellon, Shon Booker, Yuan Cheng, Joseph L Kim, Andrew Tasker, Ning Xi, Shimin Xu, Jean Christophe Harmange, George Borg, Matthew Weiss, Brian L Hodous, Russell Graceffa, William H Buckner, Craig E Masse, Deborah Choquette, Matthew W Martin, Julie Germain, Lucian V DiPietro, Stuart C Chaffee, Joseph J Nunes, John L Buchanan, Gregory J Habgood, David C McGowan, Douglas A Whittington, Daniel La, Vinod F Patel: Compounds and methods of use. Amgen, Joseph W Bulock, Ronald S Hermenau, October 14, 2008: US07435823 (9 worldwide citation)

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and ...


7
Daniel Elbaum, Benny C Askew Jr, Shon Booker, Julie Germain, Gregory J Habgood, Michael Handley, Tae Seong Kim, Aiwen Li, Nobuko Nishimura, Vinod F Patel, Chester Chenguang Yuan, Joseph L Kim, Guolin Cai, Guoqing Chen, Michael Croghan, Lucian V Di Pietro, Celia Dominguez, Qi Huang, Leon M Smith II, Andrew Tasker, Ning Xi, Shimin Xu: Substituted arylamine derivatives and methods of use. Amgen, Joseph W Bulock, September 5, 2006: US07101868 (8 worldwide citation)

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment ...


8
Qi Huang, Guoqing Chen, Aiwen Li, Babak Riahi, Andrew Tasker, Kevin Yang, Chester Chenguang Yuan: Substituted anthranilic amide derivatives and methods of use. Amgen, Joseph W Bulock, Ronald S Hermenau, December 11, 2007: US07307088 (6 worldwide citation)

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of dis ...


9
Guoqing Chen, Jeffrey Adams, Jean Bemis, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Qi Huang, Joseph L Kim, Xiaohu Ouyang, Vinod F Patel, Leon M Smith, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael Croghan, Tae Seong Kim: Substituted amine derivatives and methods of use. Amgen, Joseph W Bulock, April 7, 2009: US07514564 (6 worldwide citation)

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseas ...


10
Christopher Tegley, Jeffrey A Adams, Benny C Askew Jr, Michael Croghan, Daniel Elbaum, Julie Germain, Gregory J Habgood, Scott Harried, Aiwen Li, Nobuko Nishimura, Rana Nomak, Andrew Tasker, Kevin Yang: Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use. Amgen, Joseph W Bulock, Ronald S Hermenau, January 22, 2008: US07320992 (6 worldwide citation)

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of dis ...