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Andrew Simon Bell, David Brown, Nicholas Kenneth Terrett: Intermediates useful in the synthesis of pyrazolopyrimidinone antianginal agents. Pfizer, Peter C Richardson, Gregg C Benson, James T Jones, February 17, 1998: US05719283 (43 worldwide citation)

Compounds of the formula ##STR1## wherein R.sup.1 is H, C.sub.1 -C.sub.3 alkyl, C.sub.3 -C.sub.5 cycloalkyl or C.sub.1 -C.sub.3 perfluoroalkyl;


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Andrew Simon Bell, Michael Jonathan Fray, Alan Patrick Marchington, Kenneth Richardson, Peter Thomas Stephenson, Peter John Whittle: Triazole antifungal agents. Pfizer, Peter C Richardson, Paul H Ginsburg, Bryan C Zielinski, January 18, 2000: US06015825 (10 worldwide citation)

The invention relates to compounds of the formula (I) ##STR1## and pharmaceutically acceptable salts thereof, wherein Ar, Z and Het are as defined herein. The compounds of formula (I) possess activity as antifungal agents. The invention also relates to pharmaceutical compositions containing said com ...


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Robert O Hughes, Andrew Simon Bell, David Graham Brown, Dafydd Owen, Michael John Palmer, Christopher Phillips, David L Brown, Yvette M Fobian, John N Freskos, Steven E Heasley, E Jon Jacobsen, Todd Maddux, Brent Mischke, John M Molyneaux, Joseph B Moon, D Joseph Rogier Jr, Michael B Tollefson, John K Walker: Pyridine [3,4-b] pyrazinones. Pharmacia & Upjohn Company, Jennifer A Kispert, Robert T Ronau, March 8, 2011: US07902195 (9 worldwide citation)

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R2, R6A, R6B and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediate ...


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Andrew Simon Bell, Charlotte Alice Louise Lane, Charles Eric Mowbray: Pyrimidine derivatives. Pfizer, Jennifer A Kispert, Robert T Ronau, May 17, 2011: US07943628 (8 worldwide citation)

A compound of Formula (I): or a pharmaceutically and/or veterinarily acceptable derivative thereof, wherein R1, R2, R3, R4, R5, and R8 are as defined above.


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Andrew Simon Bell, Alan Daniel Brown, Marcel John De Groot, Russell Andrew Lewthwaite, Ian Roger Marsh, David Simon Millan, Manuel Perez Pacheco, David James Rawson, Nunzio Sciammetta, Robert Ian Storer, Nigel Alan Swain, Steven Matthieu Gaulier: Sulfonamide derivatives as Nav 1.7 inhibitors. Pfizer, J Michael Dixon, November 26, 2013: US08592629 (1 worldwide citation)

This invention relates to sulfonamide derivative of formula (I), to their use in medicine, to compositions containing them, to processes for their preparation, and to intermediates used in such processes. These compounds are inhibitors of Nav1.7.



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