1
Tammy Burd Mehta, Anne R Kopf Sill, J Wallace Parce, Andrea W Chow, Luc J Bousse, Michael R Knapp, Theo T Nikiforov, Steve Gallagher: Manipulation of microparticles in microfluidic systems. Caliper Technologies, Matthew B Murphy, Donald R McKenna, Quine Intellectual Property Law Group P C, October 14, 2003: US06632655 (384 worldwide citation)

Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus and integrated systems comprising arrays and a ...


2
H Garrett Wada, Anne R Kopf Sill, Marja Liisa Alajoki, J Wallace Parce, Benjamin N Wang, Andrea W Chow, Robert S Dubrow, Yevgeny Yurkovetsky, Javier Anibal Farinas: Focusing of microparticles in microfluidic systems. Caliper Technologies, Andrew L Filler, Quine Intellectual Property Law Group, July 15, 2003: US06592821 (218 worldwide citation)

Methods and systems for particle focusing to increase assay throughput and sensitivity in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations ...


3
H Garrett Wada, Anne R Kopf Sill, Marja Liisa Alajoki, J Wallace Parce, Benjamin N Wang, Andrea W Chow, Robert S Dubrow: Focusing of microparticles in microfluidic systems. Caliper Technologies, Andrew L Filler, January 14, 2003: US06506609 (196 worldwide citation)

Methods and systems for particle focusing to increase assay throughput in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, such as cells ...


4
J Wallace Parce, Theo T Nikiforov, Tammy Burd Mehta, Anne R Kopf Sill, Andrea W Chow, Michael R Knapp: Sequencing by incorporation. Caliper Technologies, Stacy Landry, Gary Baker, Quine Intellectual Property Law Group P C, September 2, 2003: US06613513 (193 worldwide citation)

Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking groups include phosphate groups and carb ...


5
Anne R Kopf Sill, Andrea W Chow, Peter C Jann, Morten J Jensen, Michael Spaid, Colin B Kennedy, Michael J Kennedy: Ultra high throughput microfluidic analytical systems and methods. Caliper Technologies Corporation, Townsend and Townsend and Crew, March 19, 2002: US06358387 (170 worldwide citation)

Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a particular interface arrangement for implementing various analytical and control functions. Using a number of ...


6
J Wallace Parce, Theo T Nikiforov, Tammy Burd Mehta, Anne R Kopf Sill, Andrea W Chow, Michael R Knapp: Sequencing by incorporation. Caliper Life Sciences, Donald R McKenna, Ann C Petersen, September 12, 2006: US07105300 (161 worldwide citation)

Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking groups include phosphate groups and carb ...


7
Andrea W Chow, Robert S Dubrow, J Wallace Parce, Steven A Sundberg, Jeffrey A Wolk: External material accession systems and methods. Caliper Technologies, Matthew B Murphy, November 21, 2000: US06149787 (143 worldwide citation)

Methods, apparatus and systems are provided for introducing large numbers of different materials into a microfluidic analytical device rapidly, efficiently and reproducibly. In particular, improved integrated pipettor chip configurations, e.g. sippers or electropipettors, are described which are cap ...


8
Anne R Kopf Sill, Steven A Sundberg, Andrea W Chow, Claudia L Poglitsch: Dilutions in high throughput systems with a single vacuum source. Caliper Life Sciences, Donald R McKenna, February 22, 2005: US06858185 (133 worldwide citation)

Flow rates in a microfluidic device are modulated after performing serial dilutions by flow reduction channels that draw fluid from the main channel, thus reducing the flow rate. The reduction in flow rate and/or use of smaller dimension channels allow reduced reagent consumption. In addition, multi ...


9
Andrea W Chow, Anne R Kopf Sill, J Wallace Parce, Steven A Sundberg: Microfluidic devices, systems and methods for performing integrated reactions and separations. Caliper Technologies, Matthew B Murphy, August 14, 2001: US06274089 (132 worldwide citation)

Microfluidic devices for performing integrated reaction and separation operations. The devices include a planar substrate having a first surface with an integrated channel network disposed therein. The reaction region in the integrated microscale channel network has a mixture of at least first and s ...


10
Andrea W Chow, Anne R Kopf Sill, Calvin Y H Chow: Methods and software for designing microfluidic devices. Caliper Technologies, Matthew B Murphy, Andrew L Filler, December 31, 2002: US06500323 (117 worldwide citation)

Methods and systems for designing optimized fluidic channel networks for performing different analytical operations, which include the steps of selecting a driving force, identifying at least a first reaction parameter, and designing the channel network by determining channel lengths and cross-secti ...