1
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Stephen Scaringe: Functional and hyperfunctional sirna. Dharmacon, KALOW David, June 3, 2004: WO/2004/045543 (104 worldwide citation)

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.


2
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Stephen Scaringe, Steven Read: Functional and hyperfunctional siRNA. Dharmacon, Kalow & Springut, Scott D Locke Esq, April 6, 2010: US07691997 (86 worldwide citation)

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.


3
Devin Leake, Angela Reynolds, Anastasia Khvorova, William Marshall, Peter S Linsley: Modified polynucleotides for reducing off-target effects in RNA interference. Dharmacon, Merck & Co, Kalow & Springut, Scott D Locke Esq, September 29, 2009: US07595387 (76 worldwide citation)

Methods and compositions for performing RNA interference with decreased off-target effects are provided The methods and compositions permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the use of modifications to the siRNA. Uni ...


4
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Stephen Scaringe, Steven Read: siRNA targeting KRAS. Dharmacon, Kalow & Springut, Scott D Locke Esq, March 24, 2009: US07507811 (66 worldwide citation)

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.


5
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe: siRNA targeting connexin 43. Dharmacon, Kalow & Springut, Scott D Locke Esq, April 21, 2009: US07521191 (64 worldwide citation)

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated thr ...


6
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Stephen Scaringe: Functional and hyperfunctional siRNA directed against Bcl-2. Dharmacon, Kalow & Springut, Scott D Locke Esq, March 31, 2009: US07511132 (63 worldwide citation)

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing Bcl-2.


7
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Stephen Scaringe, Steven Read: siRNA targeting carbonic anhydrase II. Dharmacon, Kalow & Springut, Scott D Locke Esq, August 25, 2009: US07579457 (61 worldwide citation)

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.


8
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Stephen Scaringe, Steven Read: siRNA targeting myeloid cell leukemia sequence 1. Dharmacon, Kalow & Springut, Scott D Locke Esq, April 7, 2009: US07514550 (59 worldwide citation)

Efficient sequence specific gene silencing of myeloid cell leukemia sequence 1 is possible through the use of siRNA technology. By selecting particular siRNAs directed to myeloid cell leukemia sequence 1 by rationale design, one can maximize the generation of an effective gene silencing reagent, as ...


9
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe: siRNA targeting DNA-damage-inducible transcript 4 (DDIT4). Dharmacon, Kalow & Springut, Scott D Locke Esq, February 2, 2010: US07655788 (58 worldwide citation)

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated thr ...


10
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Stephen Scaringe: Functional and hyperfunctional siRNA. Dharmacon, Kalow & Springut, Scott D Locke Esq, January 3, 2012: US08090542 (57 worldwide citation)

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.