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Judith W Zyskind, R Allyn Forsyth: Method for identifying microbial proliferation genes. San Diego State University Foundation, Fish & Richardson PC, May 8, 2001: US06228579 (54 worldwide citation)

A method for identifying endogenous microbial proliferation genes for growth and viability is disclosed herein. The method involves exogenous nucleic acids that are used to conditionally produce antisense inhibitors of endogenous complementary mRNAs in a microorganism. Antisense fragments that resul ...


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Allyn Forsyth, Helen Barnes: Tagged ligands for enrichment of rare analytes from a mixed sample. Cellective DX Corporation, Wilson Sonsini Goodrich & Rosati, August 30, 2011: US08008032 (23 worldwide citation)

Method of enriching specific cells from cellular samples are disclosed, comprising contacting in solution a cellular sample with affinity-tagged ligands (ATLs) each comprising a first ligand linked to an affinity tag, wherein the ligand selectively binds a cellular marker of the rare cells and the a ...


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Roger Allyn Forsyth: Methods and compositions for segregating target nucleic acid from mixed nucleic acid samples. Flir Systems, Sterne Kessler Goldstein & Fox P L L C, January 6, 2015: US08927218 (7 worldwide citation)

The invention provides methods, compositions and kits for segregating a target nucleic acid from a mixed nucleic acid sample. The methods, compositions and kits comprise a non-processive endonuclease (e.g., a restriction enzyme) or an antibody that binds the target nucleic acid (e.g., has methylatio ...


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Judith W Zyskind, R Allyn Forsyth: Method for identifying microbial proliferation genes. San Diego State University Foundation California corporation, Gregory P Einhorn, Fish & Richardson PC, May 16, 2002: US20020058260-A1 (1 worldwide citation)

A method for identifying endogenous microbial proliferation genes for growth and viability is disclosed herein. The method involves exogenous nucleic acids that are used to conditionally produce antisense inhibitors of endogenous complementary mRNAs in a microorganism. Antisense fragments that resul ...


7
Judith W Zyskind, R Allyn Forsyth: Methods for identifying anti-microbial agents. San Diego State University Foundation, Fish & Richardson P C, August 2, 2005: US06924101

A method for identifying endogenous microbial proliferation genes for growth and viability is disclosed herein. The method involves exogenous nucleic acids that are used to conditionally produce antisense inhibitors of endogenous complementary mRNAs in a microorganism. Antisense fragments that resul ...


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Roger Allyn Forsyth: Kits for segregating target nucleic acid from mixed nucleic acid samples. Flir Systems, Sterne Kessler Goldstein & Fox P L L C, January 27, 2015: US08940296

The invention provides methods, compositions and kits for segregating a target nucleic acid from a mixed nucleic acid sample. The methods, compositions and kits comprise a non-processive endonuclease (e.g., a restriction enzyme) or an antibody that binds the target nucleic acid (e.g., has methylatio ...


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Liangsu Wang, Carlos Zamudio, Cheryl Malone, Robert Haselbeck, kari L Ohlsen, Judith W Zyskind, Daniel Wall, John D Trawick, Grant J Carr, Robert Yamamoto, R Allyn Forsyth, H Howard Xu: Identification of essential genes in microorganisms. Knobbe Martens Olson & Bear, February 12, 2004: US20040029129-A1

The sequences of antisense nucleic acids which inhibit the proliferation of prokaryotes are disclosed. Cell-based assays which employ the antisense nucleic acids to identify and develop antibiotics are also disclosed. The antisense nucleic acids can also be used to identify proteins required for pro ...


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R Allyn Forsyth, Kari Ohlsen, Judith W Zyskind: Genes essential for microbial proliferation and antisense thereto. Knobbe Martens Olson & Bear, September 25, 2003: US20030181408-A1

The sequences of nucleic acids encoding proteins required for E. coli proliferation are disclosed. The nucleic acids can be used to express proteins or portions thereof, to obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to ...