1
Alfred V Vasconcellos, Ionel E Teodorescu, Joel W Cummings, Dean E McBeth: Surgical instrument for establishing compression anastomosis. Pfizer Hospital Products Group, Peter C Richardson, Lawrence C Akers, John L LaPierre, March 13, 1990: US04907591 (305 worldwide citation)

A surgical instrument for installing a plurality of interlocking coupling members forming a compression anastomosis assembly, particularly suitable for use in achieving anastomosis of a resected tubular organ, with the instrument having a cutting portion designed and configured for rotational moveme ...


2
Keith E Dionne, Dwaine F Emerich, Diane Hoffman, Paul R Sanberg, Lisa Christenson, Orion D Hegre, David W Scharp, Paul E Lacy, Patrick Aebischer, Alfred V Vasconcellos, Michael J Lysaght, Frank T Gentile: Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products. Brown University Research Foundation, Brown University, Ivor R Elrifi, John Prince, Mintz Levin Cohn Ferris Glovsky and Popeo P C, July 4, 2000: US06083523 (288 worldwide citation)

An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, p ...


3
Patrick Aebischer, Moses Goddard, John G Moldauer, Paul J Mulhauser, Anne M Rathbun, Paul R Sanberg, Alfred V Vasconcellos, Nicholas F Warner: Implantable therapy systems and methods. Brown University Research Foundation, Ivor R Elrifi, Barbara A Ruskin, Fish & Neave, January 30, 1996: US05487739 (165 worldwide citation)

Implantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a debilitating condition. The method of the invention involves surgically exposing an insertion site, general ...


4
Lloyd A Sutherland, Alfred V Vasconcellos: Sternum closure device. Pfizer Hospital Products Group, Peter C Richardson, Lawrence C Akers, John L LaPierre, March 15, 1988: US04730615 (155 worldwide citation)

A sternum closure device for closing the sternum of a patient comprising a head portion, tail portion and flexible spine portion. The head portion includes a locking tang to prevent backward movement of the spine portion once it is received and engaged in the head portion. The spine is made of a bio ...


5
Keith E Dionne, Dwaine F Emerich, Diane Hoffman, Paul R Sanberg, Lisa Christenson, Orion D Hegre, David W Scharp, Paul E Lacy, Patrick Aebischer, Alfred V Vasconcellos, Michael J Lysaght, Frank T Gentile: Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products. Brown University Research Foundation, Ivor R Mintz Levin Elrifi, September 1, 1998: US05800828 (88 worldwide citation)

Immunoisolatory vehicles having a core and a surrounding jacket are disclosed, the core having a volume in excess of 1 .mu.l and at least about 10.sup.4 living cells capable of secreting a biologically active product or of providing a biological function to a patient, the cells dispersed in a biocom ...


6
Alfred V Vasconcellos, Preston J Keeler III: Blood recovery system and method. Pfizer Hospital Products Group, Peter C Richardson, Lawrence C Akers, John L LaPierre, June 18, 1991: US05024613 (67 worldwide citation)

An intraoperative blood recovery system and method for salvaging operative blood while simultaneously delivering previously collected blood to a reinfusion system. A blood collection and transfer reservoir, having multiple compartments which can be separated by vacuum or pressure barriers, is design ...


7
Keith E Dionne, Dwaine F Emerich, Diane Hoffman, Paul R Sanberg, Lisa Christenson, Orion D Hegre, David W Scharp, Paul E Lacy, Patrick Aebischer, Alfred V Vasconcellos, Michael J Lysaght, Frank T Gentile: Methods for treatment or prevention of neurodegenerative conditions using immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core. Brown University Research Foundation, Ivor R Mintz Levin Ekrufu, February 16, 1999: US05871767 (63 worldwide citation)

A method for treatment of a neurodegenerative condition in a patient comprising implanting in the patient at least one immunoisolatory vehicle comprising a corc comprising a volume of at least 1 .mu.l and at least 10.sup.4 living cells which secrete at least one biologically active product, said cel ...


8
Patrick Aebischer, Moses Goddard, John G Moldauer, Paul J Mulhauser, Anne M Rathbun, Paul R Sanberg, Alfred V Vasconcellos, Nicholas F Warner: Implantable therapy systems and methods. Brown University Research Foundation, Ivor R Elrifi, John T Prince, Mintz Levin Cohn Ferris Glovsky and Popeo P C, January 30, 2001: US06179826 (52 worldwide citation)

Implantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a dibilatating condition. The method of the invention involves surgically exposing an insertion site, general ...


9
Alfred V Vasconcellos, Preston J Keeler III: Blood recovery system and method. Pfizer Hospital Products Group, Peter C Richardson, Lawrence C Akers, John L LaPierre, May 8, 1990: US04923438 (33 worldwide citation)

An intraoperative blood recovery system and method for salvaging operative blood while simultaneously delivering previously collected blood to a reinfusion system. A blood collection and transfer reservoir, having multiple compartments which can be separated by vacuum or pressure barriers, is design ...


10
Keith E Dionne, Dwaine F Emerich, Diane Hoffman, Paul R Sanberg, Lisa Christenson, Orion D Hegre, David W Sharp, Paul E Lacy, Patrick Aebischer, Alfred V Vasconcellos, Michael J Lysaght, Frank T Gentile: Methods for making immunoisolatory implantable vehicles with a biocompatiable jacket and a biocompatible matrix core. Brown University Research Foundation, Ivor Elrifi Mintz Levin, November 10, 1998: US05834001 (30 worldwide citation)

A method of forming an implantable and retrievable immunoisolatory vehicle is disclosed, the method comprising the steps of first forming a jacket of biocompatible thermoplastic or hydrogel, and then loading the jacket with a core comprising a volume of at least 1 .mu.l and at least 10.sup.4 cells c ...