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Michael R Myers, Alfred P Spada, Paul E Persons, Martin P Maguire: Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56.sup.lck tyrosine kinases. Aventis Pharmaceuticals Product, Irving Newman, Peter Butch, December 12, 2000: US06159978 (182 worldwide citation)

This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor tyrosine kinase and/or Lck tyrosine kinase, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to diso ...


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Michael R Myers, Alfred P Spada, Paul E Persons, Martin P Maguire: Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases. Avantis Pharmaceuticals, Peter J Butch, Raymond S Parker III, February 25, 2003: US06524347 (181 worldwide citation)

This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor tyrosine kinase and/or Lck tyrosine kinase, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to diso ...


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Alfred P Spada, Michael R Myers, Martin P Maguire, Paul E Persons: Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase. Rhone Poulenc Rorer Pharmaceuticals, James A Nicholson, Martin F Savitzky, Raymond S Parker III, January 2, 1996: US05480883 (166 worldwide citation)

This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of inhibiting abnormal cell proliferation in a patient suffering from a disorder characterized by such proliferatio ...


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Michael R Myers, Alfred P Spada, Martin P Maguire, Paul E Persons: Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase. Rhone Poulenc Rorer Pharmaceuticals, Raymond S Parker III, James A Nicholson, Martin F Savitzky, January 20, 1998: US05710158 (144 worldwide citation)

This invention relates to the modulation and/or inhibition of cell signaling, cell proliferation, cell inflammatory response, the control of abnormal cell growth and cell reproduction. More specifically, this invention relates to the use of mono- and/or bicyclic aryl or heteroaryl quinazoline compou ...


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Alfred P Spada, Martin P Maquire, Paul E Persons, Michael R Myers: Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase. Rhone Poulenc Rorer Pharmaceuticals, James A Nicholsen, Martin F Savitzky, Raymond S Parker III, April 25, 1995: US05409930 (127 worldwide citation)

This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of inhibiting abnormal cell proliferation in a patient suffering from a disorder characterized by such proliferatio ...


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Alfred P Spada, Paul E Persons, Alexander Levitzki, Chaim Gilon: Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase. Rhone Poulenc Rorer Pharmaceuticals, Synnestvedt & Lechner, April 12, 1994: US05302606 (120 worldwide citation)

Methods of inhibiting cell proliferation in a patient suffering from such disorder comprising the use of a styryl-substituted heteroaryl compound wherein the heteroaryl group is a monocyclic ring with 1 or 2 heteroatoms, or a bicyclic ring with 1 to about 4 heteroatoms, said compound optionally subs ...