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Paul Theodoor Agnes Stevens, Jozef Peeters, Roger Petrus Gerebern Vandecruys, Alfred Elisabeth Stappers, Alex Herman Copmans: Fumarate of 4- [[4- [[4- (2-cyanoethenyl) -2,6-dimethylphenyl)amino] -2-pyrimidinyl]amino]benzonitrile. Philip S Johnson, Johnson & Johnson, August 27, 2009: US20090215804-A1

The present invention relates to the fumarate salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, pharmaceutical compositions comprising as active ingredient said salt and to processes for their preparation.


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Jérôme Emile Georges GUILLEMONT, Paul Theodoor Agnes Stevens, Alex Herman Copmans, Jozef Peeters, Alfred Elisabeth Stappers, Roger Petrus Gerebern Vandecruys, Paul Stoffels: Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile. Philip S Johnson, Johnson & Johnson, January 13, 2011: US20110008434-A1

The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile and to processes for their preparation.


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Paul Theodoor Agnes Stevens, Jozef Peeters, Roger Petrus Gerebem Vandecruys, Alfred Elisabeth Stappers, Alex Herman Copmans: Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino] -2-pyrimidinyl]amino]benzonitrile. June 23, 2011: US20110150996-A1

The present invention relates to the fumarate salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, pharmaceutical compositions comprising as active ingredient said salt and to processes for their preparation.


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Jerome Emile Guillemont, Paul Theodoor Agnes Stevens, Alex Herman Copmans, Jozef Peeters, Alfred Elisabeth Stappers, Roger Petrus Gerebern Vandecruys, Paul Stoffels: Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile. Philip S Johnson, Johnson & Johnson, January 8, 2009: US20090012108-A1

The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile and to processes for their preparation.


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Alex Herman Copmans, Jérôme Albert Joseph Hoet, Albert Louis Anna Willemsems, Wouter Louis J Couck, Joaanes Petrus Van Dun: Resolution of (±)-methyl phenyl[4-[4-[[[4(trifluoromethyl)-2- biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate. March 22, 2012: US20120071660-A1

The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbo ...


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Willemsens Albert Louis Anna, Verstappen Walter Louis Antoine, Copmans Alex Herman, Vandendriessche Anna Maria Jozefa, de, Knaep Alfons Gaston Maria, Venet Marc Gaston: Process for preparing enantiomerically pure 6-[(4-chlorophenyl)(1h^_-triazol-1,2,4-triazol-1-yl)methyl]-1-methyl-1h^_-benzotriazole. Janssen Pharmaceutica, Willemsens Albert Louis Anna, Verstappen Walter Louis Antoine, Copmans Alex Herman, Vandendriessche Anna Maria Jozefa, de, Knaep Alfons Gaston Maria, Venet Marc Gaston, QUAGHEBEUR Luc, May 26, 1994: WO/1994/011364

A process for preparing ($m(y))-6-[(4-chlorophenyl)(1H^_-1,2,4-triazol-1-yl)methyl]-1-methyl-1H^_-benzotriazole comprising the resolution of (±)-6-[(4-chlorophenyl-hydrazinomethyl)-1-methyl-1H^_-benzotriazole and converting the appropriate enantiomerically pure hydrazine intermediate into ($m(y))-6- ...


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COPMANS ALEX HERMAN: Resolution of (±)-methyl phenyl[4-[4-[[[4-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate. Janssen Pharmaceutica, December 2, 2010: WO/2010/136526

The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomaltriglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbon ...


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Stevens Paul Theodoor Agnes, Peeters Jozef, Vandecruys Roger Petrus Gerebe, Stappers Alfred Elisabeth, Copmans Alex Herman: Fumarate of 4-((4-(4-(2-cyanoethenyl)-2,6-dimethylphenyl)amino)-2-pyrimidinyl)amino)benzonitrile. Janssen Pharmaceutica, liudong lilian tao, November 7, 2007: CN200580038093

The present invention concerns methods and compositions of use for treatment of Alzheimer's Disease (AD). In certain embodiments, the methods concern preparation of phage-display single chain antibody libraries and screening against amyloid-beta (Abeta) protein or peptide. Anti-Abeta antibodies are ...