1
Ales Prokop, Mikhail M Dikov, Phillip Williams, Jeffrey M Davidson: Polymeric encapsulation system promoting angiogenesis. Vanderbilt University, Benjamin Aaron Adler, May 7, 2002: US06383478 (110 worldwide citation)

The present invention provides a convenient polymeric film or microparticulate vehicle to deliver protein factors into appropriate body sites to induce appropriate therapeutic effects. It also improves the existing methodologies for immunoisolation of non-human pancreatic islets (via microencapsulat ...


2
Ales Prokop: Micro-particulate and nano-particulate polymeric delivery system. Vanderbilt University, Benjamin Aaron Adler, April 27, 2004: US06726934 (68 worldwide citation)

The present invention provides a method of making particles useful in drug delivery, comprising the steps of: contacting polyanionic polymers with cations in a stirred reactor so that polyanions and the cations react to form particles.


3
Ales Prokop: Drug delivery system exhibiting permeability control. Nanodelivery, Alston & Bird, July 8, 2003: US06589563 (25 worldwide citation)

Microparticles and nanoparticles prepared from oppositely charged polymers are provided in which a drug is incorporated into the core and is conjugated to one polymer by a Schiff-base crosslink. The particles are suitable for use in injectable formulations in which the rate of release of the drug th ...


4
John P Wikswo, Franz J Baudenbacher, David Cliffel, Frederick R Haselton, Eugene J Leboeuf, Ales Prokop, Randall S Reiserer, Mark A Stremler: Bioreactors with multiple chambers. Vanderbilt University, Morris Manning & Martin, Tim Tingkang Xia Esq, July 12, 2011: US07977089 (10 worldwide citation)

A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor has a first substrate having a first surface and an opposite second surface, defining a chamber therebetween for receiving the cells and the liquid medium. The bioreactor further ...


5
Franz Baudenbacher, John P Wikswo, R Robert Balcarcel, David Cliffel, Sven Eklund, Jonathan Mark Gilligan, Owen McGuinness, Todd Monroe, Ales Prokop, Mark Andrew Stremler, Andreas Augustinus Werdich: Apparatus and methods for monitoring the status of a metabolically active cell. Vanderbilt University, Morris Manning & Martin, Tim Tingkang Xia Esq, April 27, 2010: US07704745 (5 worldwide citation)

An apparatus and methods for monitoring the status of a cell that consumes oxygen. In one embodiment of the present invention, the method includes the steps of confining the cell in a sensing volume, measuring dynamically intracellular or extracellular signaling of the cell, and determining the stat ...


6
Ales Prokop: Drug delivery system exhibiting permeability control. Nanodelivery, Alston & Bird, November 19, 2002: US06482439 (3 worldwide citation)

Microparticles and nanoparticles prepared from oppositely charged polymers are provided in which a drug is incorporated into the core and is conjugated to one polymer by a Schiff-base crosslink. The particles are suitable for use in injectable formulations in which the rate of release of the drug th ...


7
Taylor G Wang, Igor Lacik, Marcela Brissova, Amrutur V Anikumar, Ales Prokop, Alvin C Powers: Encapsulation system for the immunoisolation of living cells. Benjamin Aaron Adler, December 7, 1999: US05997900 (1 worldwide citation)

The present invention is drawn to a composition of matter comprising high viscosity sodium alginate, cellulose sulfate and a multi-component polycation. Additionally, the present invention provides methods for making capsules, measuring capsule permeability to immunologically-relevant proteins and t ...


8
Ales Prokop: Drug delivery system exhibiting permeability control. NanoDelivery, Alston & Bird, Bank Of America Plaza, February 20, 2003: US20030035838-A1 (1 worldwide citation)

Microparticles and nanoparticles prepared from oppositely charged polymers are provided in which a drug is incorporated into the core and is conjugated to one polymer by a Schiff-base crosslink. The particles are suitable for use in injectable formulations in which the rate of release of the drug th ...


9
John P Wikswo, Franz J Baudenbacher, Ales Prokop, Eugene LeBoeuf, Chang Y Chung, David E Cliffel, Frederick R Haselton, William H Hofmeister, Charles P Lin, Lisa J McCawley, Randall S Reiserer, Mark A Stremler: Capillary perfused bioreactors with multiple chambers. Vanderbilt University, Morris Manning Martin, Tim Tingkang Xia Esq, August 23, 2011: US08003378

A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite ...


10
Ales Prokop, Jeffrey M Davidson, Gianluca Carlesso, Derya Unutmaz: Nanoparticulate composition for efficient gene transfer. Benjamin Aaron Adler, Adler & Associates, July 15, 2004: US20040136961-A1

The present invention provides compositions comprising a water-based core solution and a water-based corona solution surrounding the core solution. The compositions comprise polyanionic polymers and salts and polycationic polymers and cations and is useful for adenoviral delivery of a gene or delive ...