1
Woonza Rhee, Donald G Wallace, Alan S Michaels, Ramon A Burns Jr, Louis Fries, Frank DeLustro, Hanne Bentz: Collagen-polymer conjugates. Collagen Corporation, Morrison & Foerster, November 10, 1992: US05162430 (504 worldwide citation)

Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.


2
Woonza Rhee, Donald G Wallace, Alan S Michaels, Ramon A Burns Jr, Louis Fries, Frank DeLustro, Hanne Bentz: Collagen-polymer conjugates. Collagen Corporation, Karl Bozicevic, July 12, 1994: US05328955 (305 worldwide citation)

Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type I, type II or ...


3
Woonza Rhee, Donald G Wallace, Alan S Michaels, Ramon A Burns Jr, Louis Fries, Frank DeLustro, Hanne Bentz: Biologically inert, biocompatible-polymer conjugates. Collagen Corporation, Karl Bozicevic, June 28, 1994: US05324775 (283 worldwide citation)

Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding biologically inactive, natural, biocompatible polymer to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide biocompatible conjugates. The synthetic hydrophil ...


4
Santosh K Chandrasekaran, Siegfried Darda, Alan S Michaels, Gary W Cleary: Therapeutic system for administering clonidine transdermally. ALZA Corporation, Boehringer Ingelheim, Thomas E Ciotti, Paul L Sabatine, Edward L Mandell, May 6, 1980: US04201211 (201 worldwide citation)

Therapeutic system in the form of a skin patch that administers clonidine transdermally in an initial priming dose of 10 to 300 mcg/cm.sup.2 of skin that brings the concentration of clonidine in the blood to a level sufficient to elicit alpha-adrenergic stimulation without intolerable side effects, ...


5
Richard G Buckles, Harold M Leeper, Su Il Yum, Alan S Michaels: Liquid delivery device bladder. Alza Corporation, Thomas E Ciotti, Paul L Sabatine, Edward L Mandell, November 23, 1976: US03993069 (185 worldwide citation)

An improvement in liquid dispensers, especially those used to infuse liquid drugs into patients from an expansible elastomeric bladder of specific geometry and elastomeric properties, is disclosed. The improvement is in making the bladder from an elastomeric composition whose stress relaxation does ...


6
Alan S Michaels: Device using hydrophilic polymer for delivering drug to biological environment. Alza Corporation, Paul L Sabatine, Thomas E Ciotti, Edward L Mandell, June 17, 1980: US04207893 (115 worldwide citation)

A self-powered device for delivering drug is disclosed. The device comprises (1) a substantially rigid housing, (2) a collapsible container storing a drug and having a passageway for delivering the drug in the housing, and (3) an expandable laminate positioned between the housing and the container. ...


7
Woonza Rhee, Donald G Wallace, Alan S Michaels, Ramon A Burns Jr, Louis Fries, Frank DeLustro, Hanne Bentz: Method of augmenting tissue with collagen-polymer conjugates. Collagen Corporation, Morrison & Foerster, April 26, 1994: US05306500 (112 worldwide citation)

Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.


8
Alan S Michaels, Mark S Guillod: Osmotic bursting drug delivery device. ALZA Corporation, Thomas E Ciotti, Paul L Sabatine, Edward L Mandell, December 4, 1979: US04177256 (108 worldwide citation)

A drug delivery for administering drug to an aqueous body environment at a substantially constant rate. The devices consist essentially of a mixture of drug of specific average particle size dispersed in a polymer of specific water permeability, tensile strength, and Young's modulus in specific volu ...


9
Alan S Michaels: Structured bioerodible drug delivery device. Alza Corporation, Paul L Sabatine, June 8, 1976: US03962414 (107 worldwide citation)

A drug delivery device for the continuous and controlled administration of a predetermined therapeutically effective dosage of eye drug to the eye of a mamallian patient over a prolonged period of time. The device meters the flow of polylactic acid polymer micro-encapsulated eye drug by means of a d ...


10
Woonza Rhee, Donald G Wallace, Alan S Michaels, Ramon A Burns Jr, Louis Fries, Frank DeLustro, Hanne Bentz: Collagen-polymer conjugates. Collagen Corporation, Morrison & Foerster, May 9, 1995: US05413791 (105 worldwide citation)

Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type I, type II or ...