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Stéphane De Lombaert
Rajagopal Bakthavatchalam, Charles A Blum, Harry L Brielmann, James William Darrow, Stéphane De Lombaert, Alan Hutchison, Jennifer Tran, Xiaozhang Zheng, Richard Louis Elliott, Marlys Hammond: Spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines. Pfizer, Neurogen Corporation, Ladas & Parry, May 20, 2003: US06566367 (57 worldwide citation)

Substituted spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines capable of modulating NPY5 receptor activity are provided. Such compounds may be used to modulate ligand binding to NPY5 receptors in vivo or in vitro, and are particularly useful in the treat ...


2
Stéphane De Lombaert
Stéphane De Lombaert, Alan Hutchison, Xiaozhang Zheng: Spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines. Neurogen Corporation, Lawson & Weitzen, Sonia K Guterman, September 13, 2005: US06943199 (18 worldwide citation)

Substituted spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines capable of modulating NPY5 receptor activity are provided. Such compounds may be used to modulate ligand binding to NPY5 receptors in vivo or in vitro, and are particularly useful in the treatment of a ...


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Pamela Albaugh, Alan Hutchison: Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands. Neurogen Corporation, Banner & Allegretti, January 16, 1996: US05484944 (32 worldwide citation)

The present invention encompasses structures of the formula I: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## wherein:


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Pamela Albaugh, Alan Hutchison, Charles Blum: Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands. Neurogen Corporation, Allegretti & witcoff, April 26, 1994: US05306819 (23 worldwide citation)

The present invention encompasses structures of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## where W represents an aromatic group substituted with various organic and inorganic substituents;


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Andrew Thurkauf, Alan Hutchison, Pamela Albaugh: Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands. Neurogen Corporation, Allegretti & Witcoff, May 18, 1993: US05212310 (20 worldwide citation)

The present invention encompasses structures of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## and W, X, A, B, C, D, E, R.sub.3, R.sub.4 are variables. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain ...


9
Charles A Blum, Alan Hutchison, John M Peterson: Certain substituted benzylamine derivatives a new class of neuropeptide Y1 specific ligands. Neurogen Corporation, Ladas & Parry, October 5, 1999: US05962455 (20 worldwide citation)

This invention encompasses compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein X.sub.1, X.sub.2, X.sub.3 represent organic or inorganic substituents, n is 1, 2, or 3, m is 2, 3, or 4, R.sub.1 -R.sub.4 are hydrogen or organic substituents, and B is nitrogen, ca ...


10
Pamela Albaugh, Alan Hutchison: Certain fused pyrrolecarboxanilides; a new class of GABA brain receptor ligands. Neurogen Corporation, McDonnell Boehnen Hulbert & Berghoff, March 4, 1997: US05608079 (16 worldwide citation)

The present invention encompasses structures of the formula I: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## wherein: W represents substituted or unsubstituted aryl groups;



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