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Alistair Lochead, Samir Jegham, Alain Nedelec, Frédéric Galli, Jean Jeunesse, Luc Even: 1,4-diazabicylo[3,2,2]nonane derivatives, their preparation and their therapeutic application. Sanofi Synthelabo, Michael D Alexander, Paul E Dupont, June 18, 2002: US06407095 (42 worldwide citation)

The invention relates to 1,4-diazabicyclo[3.2.2]nonane derivatives, to pharmaceutical compositions containing them, and to methods for the treatment or prevention of disorders associated with a dysfunction of the nicotinic receptors utilizing them.


2
Alistair Lochead, Samir Jegham, Alain Nedelec, Jean Jeunesse, Frédéric Galli, Luc Even: 2,5,-diazabicyclo[2.2.1]heptane derivatives, their preparation and therapeutic uses. Sanofi Synthelabo, Michael D Alexander, October 21, 2003: US06635645 (21 worldwide citation)

The invention relates to 2,5-diazabicyclo[2.2.1]heptane derivatives, to pharmaceutical compositions containing them, and to methods for the treatment or prevention of disorders associated with a dysfunction of the nicotinic receptors utilizing them.


3
Thierry Gallet, Samir Jegham, Patrick Lardenois, Alistair Lochead, Alain Nedelec: 1,4-diazabicyclo[3.2.2]nonane-4-carboxylates and carboxamide derivates, production and use thereof in therapeutics. Sanofi Aventis, Balaram Gupta, January 17, 2006: US06987106 (16 worldwide citation)

Compounds of general formula in which X represents an oxygen atom or a group of formula NZ in which Z represents a hydrogen atom or an alkyl group, n represents a number 0, 1 or 2, and R1, R2, R3, R4 and R5 each represent a hydrogen or halogen atom or a trifluoromethyl, trifluoromethoxy, cyano, hydr ...


4
Samir Jegham, Alistair Lochead, Frederic Galli, Alain Nedelec, Axelle Solignac, Laurence De Cruz: 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one derivatives for use as 5-Ht4 or H3 receptor ligands. Synthelabo, Jacobson Price Holman & Stern PLLC, July 27, 1999: US05929089 (9 worldwide citation)

Compounds corresponding to the general formula (I) ##STR1## in which R.sub.1 represents a (C.sub.1 -C.sub.4)alkyl or (C.sub.3 -C.sub.7)cycloalkylmethyl group, X.sub.1 represents a hydrogen or halogen atom or a (C.sub.1 -C.sub.4)alkoxy group or else OR.sub.1 and X.sub.1 together represent a group of ...


5
Samir Jegham, Jean Jacques Koenig, Alistair Lochead, Alain Nedelec, Yves Guminski: N-[(1,4-diazabicyclo[2.2.2] oct-2-yl)methyl] benzamide derivatives, their preparations and their application in therapeutics. Synthelabo, Foley & Lardner, September 2, 1997: US05663173 (4 worldwide citation)

An optically active isomer or a racemate of a compound of general formula (I) ##STR1## in which either R.sub.1 represents a methoxy or cyclopropylmethoxy group and


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Frédéric Galli, Odile LeClerc, Alistair Lochead, Alain Nedelec: Derivatives of 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, the preparation thereof and the application of same in therapeutics. Sanofi Aventis, Balaram Gupta, May 29, 2007: US07223750 (3 worldwide citation)

Compounds complying with the general formula (I) in which R either represents a halogen atom or a phenyl group substituted by one or more groups chosen from halogen atoms and (C1–C6)alkyl, (C1–C6)alkoxy, nitro, amino, trifluoromethyl, cyano, hydroxy, acetyl or methylenedioxy groups, or represents a ...


7
Alistair Lochead, Alain Nedelec, Mourad Saady, Philippe Yaiche: Heteroaryl substituted 2-pyridinyl and 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one derivatives. Sanofi Aventis, Mitsubishi Pharma Corporation, Balaram Gupta, June 19, 2007: US07232827 (3 worldwide citation)

The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof wherein: (I) X represents two hydrogen atoms, a sulphur atom, an oxygen atom or a C1-2 alkyl group and a hydrogen atom; Y represents a bond, an ethenylene group, an ethynylene group or a methylene group opt ...


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Thierry Gallet, Patrick Lardenois, Alistair Lochead, Séverine Marguerie, Alain Nedelec, Mourad Saady, Franck Slowinski, Philippe Yaiche: Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido{1,2-a}pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo{1,2-a}pyrimidin-5(1h)one derivatives. Sanofi aventis, Mitsubishi Pharma Corporation, Balaram Gupta, May 8, 2007: US07214682 (1 worldwide citation)

The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof wherein X represents two hydrogen atoms, a sulfur atom, an oxygen atom or a C1-2 alkyl group and a hydrogen atom; Y represents a bond, an ethenylene group, an ethynylene group an oxygen atom, a sulfur atom, ...


10
Alistair Lochead, Samir Jegham, Alain Nedelec, Axelle Solignac: 1,4-diazabicyclo [2.2.2] oct-2-ylmethyl derivatives, their preparation and therapeutic application. Sanofi Synthelabo, Foley & Lardner, May 2, 2000: US06057321 (1 worldwide citation)

The invention concerns compounds of general formula (I) ##STR1## in which R.sub.1 represents a methyl group, X.sub.1 represents a hydrogen atom, or OR.sub.1 and X.sub.1 together form a group of formula --O(CH.sub.2).sub.2 --,--O(CH.sub.2).sub.3 --, --O(CH.sub.2).sub.2 O-- or --O(CH.sub.2).sub.3 O--, ...