1
Michel Aletru, Alain Jean Braun, Claudie Namane, Olivier Venier, Christophe Philippo, Patrick Mougenot, Eric Nicolai, Stefan Gussregen: Urea derivatives of tropane, their preparation and their therapeutic application. Sanofi Aventis, Jiang Lin, March 1, 2011: US07897773 (30 worldwide citation)

The present invention is related to a compound of formula (I) wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R4, p, r and are as defined herein, its preparation, pharmaceutical composition and use as a modulator of the activity of the 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1).


2
Alain Jean Braun, Olivier Crespin, Eric Nicolai, Cecile Pascal, Olivier Venier: Tropane urea derivatives, preparation thereof and therapeutic application thereof as modulators of the activity of 11betaHSD1. Sanofi, Scully Scott Murphy & Presser P C, September 10, 2013: US08530477

The invention relates to tropane urea derivatives of general formula (I) and to the application thereof as modulators of the activity of 11β-hydroxysteroid dehydrogenose type 1 (11βHSD1).


3
Alain Jean Braun, Olivier Crespin, Claudie Namane, Eric Nicolai, Francois Pacquet, Cecile Pascal, Christophe Philippo, Olivier Venier: Substituted adamantanes and their therapeutic application. Sanofi, Scully Scott Murphy & Presser P C, September 10, 2013: US08530657

The present invention relates to tetrahydroquinoxaline urea derivatives of formula (I) as defined herein, and, to their preparation and to their therapeutic application.


4
Alain Jean Braun, Olivier Crespin, Claudie Namane, Eric Nicolai, Francois Pacquet, Cecile Pascal, Christophe Philippo, Olivier Venier: Tetrahydroquinoxaline urea derivatives. Sanofi Aventis, Scully Scott Murphy & Presser P C, July 3, 2012: US08211892

The present invention relates to tetrahydroquinoxaline urea derivatives of Formula (I): as disclosed herein, to their preparation and to their therapeutic application.


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Michel ALETRU, Alain Jean BRAUN, Claudie NAMANE, Olivier VENIER, Christophe PHILIPPO, Patrick MOUGENOT, Eric NICOLAI, Stefan GUSSREGEN: Urea derivatives of tropane, their preparation and their therapeutic application. Sanofi Aventis, Andrea Q Ryan, Sanofi Aventis Us, July 2, 2009: US20090170894-A1

The present invention is related to a compound of formula (I) wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R4, p, r and are as defined herein, its preparation, pharmaceutical composition and use as a modulator of the activity of the 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1).


7
Michel ALETRU, Alain Jean BRAUN, Claudie NAMANE, Olivier VENIER, Christophe PHILIPPO, Patrick MOUGENOT, Eric NICOLAI, Stefan GUSSREGEN: Urea derivatives of tropane, their preparation and their therapeutic application. Sanofi Aventis, Andrea Q Ryan, Sanofi Aventis Us, December 23, 2010: US20100324084-A1

The present invention is related to a compound of formula (I) wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R4, p, r and are as defined herein, its preparation, pharmaceutical composition and use as a modulator of the activity of the 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1).


8

9
Alain Jean Braun, Olivier Crespin, Eric Nicolai, Cecile Pascal, Olivier Venier: Tropane urea derivatives, preparation thereof and therapeutic application thereof as modulators of the activity of 11betahsd1. Sanofi Aventis, December 1, 2011: US20110294809-A1

The invention relates to tropane urea derivatives of general formula (I) and to the application thereof as modulators of the activity of 11β-hydroxysteroid dehydrogenose type 1 (11βHSD1).