Darwin Prockop, Alain Colige, Renato Baserga, Paul Nugent: Antisense oligonucleotides to inhibit expression of mutated and wild type genes for collagen. Thomas Jefferson University, Pennie & Edmonds, January 19, 1999: US05861502 (11 worldwide citation)

The present invention is directed to oligonucleotides that inhibit mutant COL1A1 and/or wild type COL1A1 gene expression. The present invention is further directed to methods of inhibiting mutant and/or wild type collagen gene expression using the disclosed inhibitory oligonucleotides. The oligonucl ...

Darwin J Prockop, Loretta D Spotila, Constantinos D Deltas, Larisa Sereda, Andrea Westerhausen Larson, Michael Pack, Alain Colige, James Early, Jarmo Körkkö, Leena Ala Kokko, Susanna Annunen, Tero Pihlajamaa, Mirko Vuoristo, Petteri Paassilta: Compositions and methods for detecting altered COL1A1 gene sequences. Allegheny University of the Health Sciences, Thomas Jefferson University, University of Oulu, Morgan Lewis & Bockius L, July 24, 2001: US06265157 (7 worldwide citation)

Compositions and methods useful for determining whether a subject has an alteration in a gene encoding a protein chain of Type I or Type IX collagen are described. Novel intronic sequences of five human genes, COL1A1, COL1A2, COL9A1, COL9A2, and COL9A3 are described. Methods of determining the exist ...

Alain Colige, Pierre Mineur, Charles Lambert: Vegf variants. Universite de Liege, Fenwick & West, November 11, 2010: US20100287625-A1

This invention relates to a Vascular Endothelial Growth Factor (VEGF) polypeptide, which polypeptide lacks an amino acid sequence encoded by exon 5 of the VEGF gene. This variant of VEGF is capable of eliciting activities associated with VEGF whilst showing resistance to proteolytic degradation. The ...

Alain Colige, Charles M Lapiere, Darwin J Prockop: Recombinant N-proteinase and methods and uses thereof. University of Liege, August 6, 2002: US06428998

The present invention relates to novel polynucleotide sequences encoding human N-proteinase, and the polypeptides encoded by such polynucleotide sequences. The present invention further relates to methods for using the polynucleotides encoding human N-proteinase to produce the protein.