1
Darwin Prockop, Alain Colige, Renato Baserga, Paul Nugent: Antisense oligonucleotides to inhibit expression of mutated and wild type genes for collagen. Thomas Jefferson University, Pennie & Edmonds, January 19, 1999: US05861502 (11 worldwide citation)

The present invention is directed to oligonucleotides that inhibit mutant COL1A1 and/or wild type COL1A1 gene expression. The present invention is further directed to methods of inhibiting mutant and/or wild type collagen gene expression using the disclosed inhibitory oligonucleotides. The oligonucl ...


2
Darwin J Prockop, Loretta D Spotila, Constantinos D Deltas, Larisa Sereda, Andrea Westerhausen Larson, Michael Pack, Alain Colige, James Early, Jarmo Körkkö, Leena Ala Kokko, Susanna Annunen, Tero Pihlajamaa, Mirko Vuoristo, Petteri Paassilta: Compositions and methods for detecting altered COL1A1 gene sequences. Allegheny University of the Health Sciences, Thomas Jefferson University, University of Oulu, Morgan Lewis & Bockius L, July 24, 2001: US06265157 (7 worldwide citation)

Compositions and methods useful for determining whether a subject has an alteration in a gene encoding a protein chain of Type I or Type IX collagen are described. Novel intronic sequences of five human genes, COL1A1, COL1A2, COL9A1, COL9A2, and COL9A3 are described. Methods of determining the exist ...


3
Alain Colige, Pierre Mineur, Charles Lambert: Vegf variants. Universite de Liege, Fenwick & West, November 11, 2010: US20100287625-A1

This invention relates to a Vascular Endothelial Growth Factor (VEGF) polypeptide, which polypeptide lacks an amino acid sequence encoded by exon 5 of the VEGF gene. This variant of VEGF is capable of eliciting activities associated with VEGF whilst showing resistance to proteolytic degradation. The ...


4
Alain Colige, Charles M Lapiere, Darwin J Prockop: Recombinant N-proteinase and methods and uses thereof. University of Liege, August 6, 2002: US06428998

The present invention relates to novel polynucleotide sequences encoding human N-proteinase, and the polypeptides encoded by such polynucleotide sequences. The present invention further relates to methods for using the polynucleotides encoding human N-proteinase to produce the protein.


5


Click the thumbnails below to visualize the patent trend.