1
Adam E Cohen: Near-field photolithographic masks and photolithography; nanoscale patterning techniques; apparatus and method therefor. Orrick Herrington & Sutcliffe, February 2, 1999: US05865978 (37 worldwide citation)

A new field of technology, near-field photolithography, is proposed. In near-field photolithography, an opaque pattern having a nanoscale resolution is made using a modified scanning tunneling microscope to deposit the opaque material on an electrically conductive material. A transparent sheet of in ...


2
Adam E Cohen, Joel M Kralj, Adam D Douglass: Optogenetic probes for measuring membrane potential. President and Fellows of Harvard College, Wolf Greenfield & Sacks P C, C Hunter Baker, Gitrada A Harmon, June 16, 2015: US09057734 (24 worldwide citation)

The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using electrodes. The methods can be directed to, for example, high-throughput drug screening assays to determ ...


3
Charles T Black, Adam E Cohen, Christopher B Murray, Robert L Sandstrom: Scanning probe microscopy tips composed of nanoparticles and methods to form same. International Business Machines Corporation, Gibb & Rahman, Ido Tuchman Esq, October 16, 2007: US07282710 (11 worldwide citation)

A structure and method for improving the spatial resolution of a scanning probe microscope (SPM) tip, which has been coated with a layer of chemically-synthesized nanoparticles. The nanoparticles are either single-species or heterogeneous, such that the single-species nanoparticles can be either fer ...


4
Adam E Cohen, Joel Kralj, Adam D Douglass, Daniel Hochbaum: Systems, methods, and workflows for optogenetics analysis. President and Fellows of Harvard College, Wolf Greenfield & Sacks P C, December 8, 2015: US09207237 (5 worldwide citation)

The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both ...


5
Adam E Cohen, Daniel Hochbaum, Peng Zou, Samouil Leon Farhi, Robert Earl Campbell, Yongxin Zhao, Daniel Jed Harrison: Optogenetic probes for measuring membrane potential. President and Fellows of Harvard College, The Governors of the University of Alberta, Wolf Greenfield & Sacks P C, December 13, 2016: US09518103 (2 worldwide citation)

Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, cells comprising the polynucleotides, and cells comprising the p ...


6
Jonathan M Rothberg, Ali Kabiri, Jason W Sickler, Brett J Gyarfas, Jeremy Lackey, Gerard Schmid, Benjamin Cipriany, Jack Jewell, Lawrence West, Michael Ferrigno, Paul E Glenn, Adam E Cohen, Anthony Bellofiore: Optical system and assay chip for probing, detecting and analyzing molecules. Quantum Si Incorporated, Wolf Greenfield & Sacks P C, January 9, 2018: US09863880

Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emissi ...


7
Adam E Cohen, Joel Kralj, Adam D Douglass, Daniel Hochbaum: Systems, methods, and workflows for optogenetics analysis. President and Fellows of Harvard College, Wolf Greenfield & Sacks P C, July 11, 2017: US09702874

The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both ...


8
Adam E Cohen, Joel Kralj, Adam D Douglass: Optogenetic probes for measuring membrane potential. President and Fellows of Harvard College, Wolf Greenfield & Sacks P C, October 17, 2017: US09791455

The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using electrodes. The methods can be directed to, for example, high-throughput drug screening assays to determ ...


9
Adam E Cohen, William E Moerner: Sub-micron object control arrangement and approach therefor. The Board of Trustees of the Leland Stanford Junior University, Crawford Maunu PLLC, November 15, 2011: US08057655

Sub-micron objects are manipulated. According to an example embodiment of the present invention, Brownian motion effects are mitigated to facilitate the analysis and/or manipulation of sub-micron objects. In some applications, an electric field is applied to facilitate the manipulation of sub-micron ...


10
Adam E Cohen, Sabrina R Leslie: Convex lens-induced confinement for measuring distributions of molecular size. President and Fellows of Harvard College, Wilmer Cutler Pickering Hale and Dorr, August 14, 2018: US10048193

A curved surface is placed tangent to a slide and displaces a sample liquid from the point or line of contact outward. Imaging indicates a region where fluorescence is observed, and the location of the fluorescence indicates the molecular size. The radius of curvature of the lens is known, the dista ...