1
Abraham J Domb, Ruxandra Gref, Yoshiharu Minamitake, Maria Teresa Peracchia, Robert S Langer: Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers. Massachusetts Institute of Technology, Arnall Golden & Gregory, December 28, 1999: US06007845 (300 worldwide citation)

Particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified to achieve variable release rates or to target specific cells or organs. The particles have a core of a multiblock copolymer formed by covalently l ...


2
Abraham J Domb, Alain Shikani, Andrew S T Haffer, Manoj Maniar: Anti-infective and anti-inflammatory releasing systems for medical devices. Leonard Bloom, Leonard Bloom, April 30, 1996: US05512055 (245 worldwide citation)

Devices are provided having a polymer coating incorporating compounds inhibiting inflammation and infection, along with subsequent tissue growth onto and around the device. Preferred embodiments include catheters, tubes, and implants that abut tissue following implantation into the body, especially ...


3
Abraham J Domb: Lipsopheres for controlled delivery of substances. Nova Pharmaceutical Corporation, Kilpatrick & Cody, February 23, 1993: US05188837 (231 worldwide citation)

A microsuspension system and method for its preparation is disclosed. The microsuspension contain lipospheres, which are solid, water-insoluble microparticles that have a layer of a phospholipid embedded on their surface. The core of the liposphere is a solid substance to be delivered, or a substanc ...


4
Henry Brem, Robert S Langer, Abraham J Domb: Controlled local delivery of chemotherapeutic agents for treating solid tumors. Massachusetts Institute of Technology, The Johns Hopkins University, Arnall Golden & Gregory, May 6, 1997: US05626862 (190 worldwide citation)

A method and devices for localized delivery of a chemotherapeutic agent to solid tumors, wherein the agent does not cross the blood-brain barrier and is characterized by poor bioavailability and/or short half-lives in vivo, are described. The devices consist of reservoirs which release drug over an ...


5
Abraham J Domb, Ruxandra Gref, Yoshiharu Minamitake, Maria T Peracchia, Robert S Langer: Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers. Massachusetts Institute of Technology, Arnall Golden & Gregory, November 26, 1996: US05578325 (151 worldwide citation)

Injectable particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified as necessary to achieve variable release rates or to target specific cells or organs as desired. The injectable particles can include ma ...


6
Alain H Shikani, Abraham J Domb: Anti-infective and anti-inflammatory releasing systems for medical devices. Leonard Bloom, June 9, 1998: US05762638 (125 worldwide citation)

Medical devices for implantation into the body are coated with anti-infective and or anti-inflammatory agents. The medical devices can be, for example, endotracheal/tracheostomy tubes and catheters. The devices have a polymer coating containing an anti-infective agent and/or an anti-inflammatory age ...


7
Abraham J Domb, Robert S Langer: High molecular weight polyanhydride and preparation thereof. Massachusetts Institute of Technology, Kilpatrick & Cody, July 12, 1988: US04757128 (120 worldwide citation)

High molecular weight polyanhydrides, defined as polyanhydrides having a molecular weight average greater than 20,000 or an intrinsic viscosity of greater than 0.3 dl/g in an organic solvent at room temperature, are formed by melt polycondensation of highly pure isolated prepolymers under optimized ...


8
Abraham J Domb, Robert S Langer: Polyanhydrides with improved hydrolytic degradation properties. Massachusetts Institute of Technology, Kilpatrick & Cody, August 15, 1989: US04857311 (106 worldwide citation)

Polyanhydrides with uniform distribution of alkyl and aromatic residues are prepared by melt polycondensation or solution polymerization of p-carboxyphenoxyalkanoic acids or p-carboxyphenylalkanoic acids. These polymers are soluble in common organic solvents and have low melting points, generally in ...


9
Henry Brem, Robert S Langer, Abraham J Domb: Controlled local delivery of chemotherapeutic agents for treating solid tumors. Massachusetts Institute of Technology, The Johns Hopkins University, Arnall Golden & Gregory, July 29, 1997: US05651986 (98 worldwide citation)

A method and devices for localized delivery of a chemotherapeutic agent to solid tumors, wherein the agent does not cross the blood-brain barrier and is characterized by poor bioavailability and/or short half-lives in vivo, are described. The devices consist of reservoirs which release drug over an ...


10
Abraham J Domb, Alain H Shikani: Method and device for inhibiting HIV, hepatitis B and other viruses and germs when using a catheter in a medical environment. Leonard Bloom, Leonard Bloom, September 6, 1994: US05344411 (96 worldwide citation)

An anti-infective coating for a catheter or other medical device. The coating is insoluble in a biological medium and is bound to the surfaces of the catheter. The coating is a biocompatible, non-hydrogel polymer. One embodiment is a coating on the catheter which is complexed with an iodine solution ...



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