1
Kenneth Alan Simmen, Herman Augustinus De Kock, Pierre Jean Marie Bernard Raboisson, Lili Hu, Abdellah Tahri, Dominique Louis Nestor Ghislain Surleraux, Karl Magnus Nilsson, Bengt Bertil Samuelsson, Åsa Annica Kristina Rosenquist, Vladimir Ivanov, Mikael Pelcman, Anna Karin Gertrud Linea Belfrage, Per Ola Mikael Johansson, Sandrine Marie Helene Vendeville: Macrocylic inhibitors of hepatitis C virus. Tibotec Pharmaceuticals, Medivir, Woodcock Washburn, January 8, 2013: US08349869 (9 worldwide citation)

Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR7, —NH—SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hyd ...


2
Kenneth Alan Simmen, Herman Augustinus De Kock, Pierre Jean Marie Bernard Raboisson, Sandrine Marie Helene Vendeville, Lili Hu, Wim Van De Vreken, David Craig McGowan, Abdellah Tahri, Dominique Louis Nestor Ghislain Surleraux: Macrocyclic inhibitors of hepatitis C virus. Tibotec Pharmaceuticals, August 2, 2011: US07989471 (8 worldwide citation)

Inhibitors of HCV of formula (I) and the N-oxides, salts, and stereochemically isomeric forms thereof, wherein the terms R1, L, R2, R3, R4, and n have specific definitions; pharmaceutical compositions containing compounds of formula (I), and processes for preparing compounds of formula (I). Bioavail ...


3
Kenneth Alan Simmen, Herman Augustinus De Kock, Pierre Jean Marie Bernard Raboisson, Sandrine Marie Helene Vendeville, Lili Hu, Abdellah Tahri, Dominique Louis Nestor Ghislain Surleraux, Wim Van De Vreken, Ismet Dorange, Yvan Simonnet, Karl Magnus Nilsson, Bengt Bertil Samuelsson, Asa Annica Kristina Rosenquist, Hans Kristian Wallberg: Macrocyclic inhibitors of hepatitis C virus. Tibotec Pharmaceuticals Co, Medivir, Andrea Jo Kamage, September 6, 2011: US08012939 (6 worldwide citation)

Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers thereof, wherein each variable has specific definitions. Pharmaceutical compositions containing compounds (I) and process for preparing compounds (I) are also provided. Bioavailable combinations of the inhibitors ...


4
Tim Hugo Maria Jonckers, Pierre Jean Marie Raboisson, Koen Vandyck, Steven Maurice Van Hoof, Lili Hu, Abdellah Tahri: Uracyl spirooxetane nucleosides. Janssen Products, Medivir, Andrea Jo Kamage, July 9, 2013: US08481510 (6 worldwide citation)

Compounds of the formula I: including any possible stereoisomers thereof, wherein: R4 is a monophosphate, diphosphate or triphosphate ester; or R4 is R7 is optionally substituted phenyl, optionally substituted naphthyl, or optionally substituted indolyl; R8 and R8′ are hydrogen, C1-C6alkyl, benzyl, ...


5
Abdellah Tahri, Piet Tom Bert Paul Wigerinck: Broadspectrum substituted oxindole sulfonamide HIV protease inhibitors. Tibotec Pharmaceuticals, April 3, 2007: US07199148 (4 worldwide citation)

The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radical o ...


6
Sandrine Marie Helene Vendeville, Pierre Jean Marie Bernard Raboisson, Tse I Lin, Abdellah Tahri, Katie Ingrid Eduard Amssoms: Macrocyclic indole derivatives useful as hepatitis C virus inhibitors. Janssen R & D Ireland, Andrea Jo Kamage, December 30, 2014: US08921355 (3 worldwide citation)

Inhibitors of HCV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R1, R2, R4, R5, R6 and R7 have the meaning defined in the claims. The present invention also relates to processes for preparing said compounds, pharmaceutical compos ...


7
Dominique Louis Nestor Ghislain Surleraux, Sandrine Marie Helene Vendeville, Wim Gaston Verschueren, Marie Pierre T M M G De Bethune, Herman Augustinus De Kock, Abdellah Tahri, Montserrat Erra Solà: Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors. Tibotec Pharmaceuticals, July 17, 2007: US07244752 (2 worldwide citation)

The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radical o ...


8
Tim Hugo Maria Jonckers, Pierre Jean Marie Bernard Raboisson, Koen Vandyck, Steven Maurice Paula Van Hoof, Lili Hu, Abdellah Tahri: Uracyl spirooxetane nucleoside phosphoramidates. Janssen Products, Medivir, April 21, 2015: US09012428 (2 worldwide citation)

This invention relates to a stereochemically pure uracyl spirooxetane nucleoside phosphoramidate useful in the treatment of patients infected with the hepatitis C virus (HCV).


9
Tim Hugo Maria Jonckers, Pierre Jean Marie Bernard Raboisson, Koen Vandyck, Steven Maurice Paula Van Hoof, Lili Hu, Abdellah Tahri: Uracyl spirooxetane nucleosides. Janssen Products, Medivir, January 13, 2015: US08933052 (2 worldwide citation)

Compounds of the formula I: including any possible stereoisomers thereof, wherein: R4 is a monophosphate, diphosphate or triphosphate ester; or R4 is R7 is optionally substituted phenyl, optionally substituted naphthyl, or optionally substituted indolyl; R8 and R8′ are hydrogen, C1-C6alkyl, benzyl, ...


10
Abdellah Tahri, Lili Hu, Dominique Louis Nestor Ghislain Surleraux, Piet Tom Bert Paul Wigerinck: -pyrazolo[1,5-c][1,3]Benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors, (1,10B-dihydro-2-(aminoalkyl-phenyl)-5. Tibotec Pharmaceuticals, Yunling Ren, December 16, 2008: US07465727 (2 worldwide citation)

The present invention relates to 5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as inhibitors of the viral replication of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The prese ...