1
Ilsoon Lee, Wei Wang, Shaowen Ji: One-step method for pretreating biomass using nanomixing. Board of Trustees of Michigan State University, Clark IP Law, June 3, 2014: US08741632 (2 worldwide citation)

Methods and devices for treatment of biomass comprised of crystalline structures are described that provide a combined mechanical, chemical and thermal effect (i.e., nano-hybrid pretreatment) to synergistically break down the crystalline structures. Such nano-hybrid mixing provides efficient, and co ...


2
Robert M Worden, Robert Y Ofoli, Brian L Hassler, Neeraj Kohli, Ilsoon Lee: Customizable and renewable nanostructured interface for bioelectronic applications. Board of Trustees of Michigan State University, Clark IP Law, May 7, 2013: US08435773 (1 worldwide citation)

A chemical composite useful for preparing a bioelectronic device includes a biologically active compound, such as an enzyme, that is bound directly or indirectly to a polyelectrolyte, which can be reversibly coupled to a chemically treated electrically conductive substrate by electrostatic forces to ...


3
Neeraj Kohli, Devesh Srivastava, Rudy J Richardson, Jun Sun, Ilsoon Lee, Robert M Worden: Nanostructured biosensor containing neuropathy target esterase activity. Michigan State University, The Regents of the University of Michigan, Schwegman Lundberg & Woessner P A, January 7, 2014: US08623196 (1 worldwide citation)

The present invention provides compositions, devices and methods for detecting esterase activity. The present invention also provides devices and methods of detecting esterase inhibitors, for example, organophosphates. In particular, the present invention provides a biosensor comprising Neuropathy T ...


4
Robert Mark Worden, Brian L Hassler, Lawrence T Drzal, Ilsoon Lee: Electrobiocatalytic reactors having reversible bioelectronic interfaces and methods and devices related thereto. Board of Trustees of Michigan State University, August 2, 2016: US09406959

An inexpensive, easily renewable bioelectronic device useful for bioreactors, biosensors, and biofuel cells includes an electrically conductive carbon electrode and a bioelectronic interface bonded to a surface of the electrically conductive carbon electrode, wherein the bioelectronic interface incl ...


5
Ilsoon Lee, Wei Wang, Ankush Gokhale: Methods for coating metals on hydrophobic surfaces. Board of Trustees of Michigan State University, Harness Dickey & Pierce, April 11, 2017: US09617643

A method of plating a metal on a hydrophobic polymer, especially in the shape of small particles, involves: (a) contacting a surface of hydrophobic polymer substrate with a polycation such as poly(allylamine hydrochloride) to create a treated surface; (b) contacting the treated surface with a cataly ...


6
Ilsoon Lee, Lawrence T Drzal, Jue Lu, Troy R Hendricks: Micropatterning of conductive graphite particles using microcontact printing. Board of Trustees of Michigan State University, Harness Dickey & Pierce, May 5, 2015: US09023478

Methods involve a combination of polyelectrolyte multilayer (PEM) coating or silane self assembly on a substrate; microcontact printing; and conductive graphite particles, especially size controlled highly conductive exfoliated graphite nanoplatelets. The conductive graphite particles are coated wit ...


7
Ilsoon Lee, Shaowen Ji: Device and method for encapsulation of hydrophilic materials. Board of Trustees of Michigan State University, Harness Dickey & Pierce, April 12, 2016: US09308172

A process for preparing polymeric composite particles includes the steps of preparing an oil phase containing a biodegradable polymer and a water phase containing a hydrophilic compound or nanoparticle and emulsifying the oil phase in the water phase to form emulsions. Then solvent is removed from t ...


8
Ilsoon Lee, Troy R Hendricks: Wrinkle-free nanomechanical film. Board of Trustees of Michigan State University, Harness Dickey & Pierce, June 11, 2013: US08460785

Methods to control and prevent polymer films from buckling are provided. Buckled morphologies are created by thermally cycling or mechanically compressing a substrate such as poly(dimethylsiloxane) (PDMS) coated with a polyelectrolyte multilayer film. By varying the dimensions of the surface topogra ...


9
Ilsoon Lee, Christina Chan, Srivatsan Kidambi: Cell adhesion on surfaces of varying topographies. Harness Dickey & Pierce, October 2, 2008: US20080241926-A1

Micro-topography of a surface influences cell adhesion and proliferation. To improve adhesion, polyelectrolyte multilayers (PEMs) are built on patterned support layers to increase surface wettability, thereby improving attachment and spreading of the cells. Physical parameters, such as pattern size ...


10
Christina Chan, Ilsoon Lee, Srivatsan Kidambi: Salt and pH tunable resist patterns on polyelectrolyte multilayers. Harness Dickey & Pierce, September 27, 2007: US20070224175-A1

A method for selectively removing a resist material from the polycationic surface of a polyelectrolyte multilayer (PEM) film, without disturbing adhering interactions between the cationic film surface and bound biomaterials such as cells, proteins, and nucleic acids. The resist material is one that ...



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