1
Zygraich Nathan, Huygelen Constant: Live bovine adenovirus vaccines, preparation thereof and method of vaccination using them. Recherche et Industrie Therapeutiques, Lourie Alan D, Edgerton William H, December 16, 1975: US3927208 (8 worldwide citation)

The invention relates to virus vaccines containing temperature-sensitive mutant strains of bovine Adenovirus, the cut-off temperature of said mutant strain being comprised between 39.degree. and 40.degree. C.The invention also relates to the induction of said temperature-sensitive mutant strains and ...


2
Zygraich Nathan, Huygelen Constant: Herpes simplex type 2 virus vaccine and method of production and use. Recherche et Industrie Therapeutiques, Lourie Alan D, Edgerton William H, July 29, 1975: US3897549 (5 worldwide citation)

The invention pertains to the preparation of temperature-sensitive and substantially non-pathogenic mutant strains of Herpes Simplex type 2 virus which are valuable for the preparation of vaccines, to the vaccines containing said temperature-sensitive mutant strains and to a new vaccination method a ...


3
Huygelen Constant, Peetermans Julien: Attenuated live rubella virus vaccine and method of production. August 22, 1972: US3686394 (2 worldwide citation)

Rubella virus is passaged in primary rabbit kidney tissue at least 15 times, preferably 51-61 times, at temperatures of 28.degree.-36.degree. C, to obtain an effective vaccine. Test data are disclosed.


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Huygelen Constant, Peetermans Julien: Newcastle disease vaccine and the preparation thereof. Rit Rech Ind Therapeut, March 4, 1964: GB951559-A

A vaccine comprises the Komarov KH strain of Newcastle disease virus cultivated on mammalian kidney tissue culture of one mammalian species, e.g. calf or more than one mammelian species, e.g. calf and pig. In general, more than one serial passage is used, e.g. 21 passages through calf kidney culture ...


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Zygraich Nathan, Huygelen Constant: Adenovirus bovins non pathogenes sensibles a la temperature, Temperature sensitive and non-pathogenic bovine adenovirus. Recherche Et Industrie Therapeutiques Rit, September 26, 1978: CA1039186

ABSTRACT OF THE DISCLOSUREThe invention relates to the preparation oftemperature-sensitive and substantially non-pathogenicbovine Adenovirus, more particularly Adeno 3 virus, strainsby mutagenesis with nitrous acid. The temperature-sensitivestrains have a cut-off temperature comprised between 39 and ...


6
Huygelen Constant, Peetermans Julien: Attenuated live rubella virus vaccine and method of production. Rit Rech Ind Therapeut, December 11, 1968: GB1135987-A

1,135,987. Rubella vaccine; attenuating viruses. RECHERCHE ET INDUSTRIE THERAPEUTIQUES. 21 Oct., 1966, No. 47399/66. Heading A5B. Virulent Rubella virus is attenuated for use in a vaccine against Rubella, by subjecting it to at least fifteen serial passages on primary rabbit kidney tissue cultures. ...


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