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Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier Jr, Srinivasan R Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz: Substituted benzopyran derivatives for the treatment of inflammation. G D Searle & Co, Joseph W Bulock, March 7, 2000: US06034256 (41 worldwide citation)

A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1## wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.sup.2 are as described in the specification.


2
Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier Jr, Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz, Donald E Korte: Substituted benzopyran analogs for the treatment of inflammation. G D Searle & Co, Joseph W Bulock, June 20, 2000: US06077850 (23 worldwide citation)

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I'wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.su ...


3
Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier Jr, Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz, Donald E Korte: Substituted benzopyran derivatives for the treatment of inflammation. G D Searle & Co, James M Warner, Joseph W Bulock, August 7, 2001: US06271253 (19 worldwide citation)

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′


4
Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier Jr, Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz, Donald E Korte: Substituted benzopyran analogs for the treatment of inflammation. G D Searle & Co, McDonnell Boehnen Hulbert & Berghoff, December 10, 2002: US06492390 (14 worldwide citation)

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′


5
David L Brown, Matthew J Graneto, Cindy L Ludwig, John M Molyneaux, John J Talley: Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation. Pharmacia Corporation, January 6, 2004: US06673818 (8 worldwide citation)

Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more fluoro-substituted benzenesulfonyl compounds corresponding to Formula I:


6
Beth Jo Calabotta, Kevin Lee Deppermann, Erik Dersch, Jerald D Heise, Angela Ranae Koestel, Cindy L Ludwig, Brian J Martinell, Edward Williams: Preparation and use of plant embryo explants for transformation. Monsanto Technology, SNR Denton US, Thomas P McBride Esq, January 29, 2013: US08362317 (6 worldwide citation)

The present invention relates to excision of explant material comprising meristematic tissue from seeds, and storage of such material prior to subsequent use in plant tissue culture and genetic transformation. Methods for tissue preparation, storage, and transformation are disclosed, as is transform ...


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David L Brown, Matthew J Graneto, Cindy L Ludwig, John M Molyneaux, John J Talley: Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation. Pharmacia Corporation, March 2, 2004: US06699884 (5 worldwide citation)

Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more fluoro-substituted benzenesulfonyl compounds corresponding to Formula I:


8
Muhammad Anzar, Cindy L Ludwig, Jeffrey A Graham, Jeanette A Glaenzer: Monsanto Technology, Senniger Powers, Joseph A Schaper, February 26, 2008: US07335507 (3 worldwide citation)

Sperm cells are stained according to processes that involve the combining of sperm cells with a fluorescent DNA selective dye at an elevated temperature in excess of about 40° C. The methods allow for a decreased staining time. The cells may thereafter be efficiently sorted according to common separ ...


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Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier Jr, Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz, Donald E Korte: Substituted benzopyran derivatives for the treatment of inflammation. G D Searle & Co, Julie M Lappin, Charles Ashbrook, November 21, 2006: US07138411 (3 worldwide citation)

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the s ...



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