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Christopher J Kyricos, Charles A Czeisler, Richard E Kronauer: Apparatus for producing and delivering high-intensity light to a subject. Light Sciences, Brigham and Women s Hospital April 2, 1996: US05503637 (35 worldwide citation)

The present invention is an apparatus for producing and delivering high-intensity light to the eyes of a subject to modify the subject's circadian phase. The apparatus includes a support for positioning the apparatus above the eyes of the subject, a light generator for producing a cool, high-intensi ...


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Charles A Czeisler, Richard E Kronauer, James S Allan: Assessment and modification of circadian phase and amplitude. Brigham and Women s Hospital January 5, 1993: US05176133 (20 worldwide citation)

A method for accurately assessing and rapidly modifying the phase and amplitude of the endogenous circadian pacemaker is disclosed. A circadian cycle modification capacity assessment method comprises (before and after a stimulus) eliminating activity-related confounding factors associated with the s ...


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Charles A Czeisler, Richard E Kronauer, James S Allan: Assessment and modification of endogenous circadian phase and amplitude. Brigham and Women s Hospital December 1, 1992: US05167228 (20 worldwide citation)

A method for accurately assessing and rapidly modifying the phase and amplitude of the endogenous circadian pacemaker is disclosed. A circadian cycle modification capacity assessment method comprises (before and after a stimulus) eliminating activity-related confounding factors associated with the s ...


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Charles A Czeisler, Richard E Kronauer, James S Allan: Assessment and modification of a subjects endogenous circadian cycle. Brigham and Women s Hospital November 17, 1992: US05163426 (19 worldwide citation)

A method for accurately assessing and rapidly modifying the phase and amplitude of the endogenous circadian pacemaker is disclosed. A circadian cycle modification capacity assessment method comprises (before and after a stimulus) eliminating activity-related confounding factors associated with the s ...


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Charles A Czeisler, Richard E Kronauer: Intermittent use of bright light to modify the circadian phase. Brigham and Women s Hospital August 13, 1996: US05545192 (18 worldwide citation)

The present invention is a method for modifying the circadian cycle of a human subject to a desired state including the steps of determining the characteristics of the desired circadian cycle, selecting an appropriate time during which to apply a light stimulus to effect a desired modification of th ...


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Charles A Czeisler, Heinz Martens, Theresa L Shanahan: Test for evaluation of visual functioning in visually impaired subjects. Brigham and Women s Hospital September 15, 1992: US05146927 (1 worldwide citation)

A method of determining the functional integrity of the visual system (including the photoreceptive elements, the retino-hypothalamic tracts and their connections to the suprachiasmatic nuclei of the hypothalamus) of visually imparied human beings. The method includes measuring the melatonin content ...


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Florian G Bell, Donna K Barton, Charles A Czeisler: System and Method for Monitoring Information Related to Sleep. RIC Investments December 25, 2008: US20080319354-A1

A system configured to monitor ambient illumination experienced by a subject. In one embodiment, the system comprises an illumination sensor, a timer, and a storage module. The illumination sensor is configured to monitor an intensity of ambient illumination within two or more wavelength ranges by g ...


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Charles A Czeisler, Frank AJL Scheer: Methods and compositions for treatment of hypertension. The Brigham and Women s Hospital June 23, 2005: US20050137247-A1

Methods and compositions for treating and/or preventing hypertension are provided. The methods involve administration of melatonin, or an analog thereof, to a subject. The methods and compositions may be used to treat various forms of hypertension, including essential hypertension.


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Charles A Czeisler, Steven W Lockley, Richard E Kronauer, George C Brainard: Method for modifying or resetting the circadian cycle using short wavelength light. May 18, 2006: US20060106437-A1

The present invention is a method for modifying the circadian cycle of a human subject to a desired state. The method includes the steps of assessing the present circadian cycle of the human subject, determining the characteristics of a desired circadian cycle, selecting an appropriate time during w ...



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