1
Rodents With Conditional ACVR1 Mutant Alleles. February 14, 2019: US20190045760-A1

A genetically modified mouse is provided that comprises a conditional Acvr1 allele that comprises a mutated exon that, upon induction, converts to a mutant exon phenotype, wherein the mutant exon phenotype includes ectopic bone formation. Mice comprising a mutant Acvr1 exon 5 in antisense orientatio ...


2
Contiguity Preserving Transposition. February 14, 2019: US20190048332-A1

Embodiments provided herein relate to methods and compositions for preparing an immobilized library of barcoded DNA fragments of a target nucleic acid, identifying genomic variants, determining the contiguity information, phasing information, and methylation status of the target nucleic acid.


3
METHOD FOR DIAGNOSING OR MONITORING KIDNEY FUNCTION OR DIAGNOSING KIDNEY DYSFUNCTION. SPHINGOTEC, February 14, 2019: US20190049470-A1

A method for (a) diagnosing or monitoring kidney function in subject or (b) diagnosing kidney dysfunction in a subject or (c) predicting or monitoring the risk of an adverse events in a diseased subject or (d) predicting or monitoring the success of a therapy or intervention comprising determining t ...


4
VARIANT POLYPEPTIDES CAPABLE OF AMINATING ALIPHATIC ALPHA KETO ACIDS. February 14, 2019: US20190048326-A1

Disclosed are, among other things, variant polypeptides, nucleic acids encoding the polypeptides, production of the variant polypeptides, and use of the variant polypeptides in various applications, such as screening and synthetic methods. For example, the variant polypeptides, or enzymatically-acti ...


5
Oxidising Agent for Modified Nucleotides. February 14, 2019: US20190048406-A1

This invention relates to the use of metal (VI) oxo complexes to catalyse the selective oxidation of 5hmC residues in polynucleotides to 5fC residues. This may be useful in the identification of modified cytosine residues in a population of polynucleotides comprising a sample nucleotide sequence. A ...


6
SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS. The Children s Medical Center Corporation, The United States of America Represented by the Secretary Department of Health & Human Servic, February 14, 2019: US20190048407-A1

The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is rela ...


7
PROTEIN BINDING DOMAINS STABILIZING FUNCTIONAL CONFORMATIONAL STATES OF GPCRS AND USES THEREOF. February 14, 2019: US20190049463-A1

The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifical ...


8
EFFICIENT HIGH-VELOCITY COMPRESSED GAS-POWERED GUN. February 14, 2019: US20190049211-A1

A lower receiver has a trigger assembly. An upper receiver is coupled to the lower receiver. The lower receiver has a bolt assembly and an L-shaped slot. The L-shaped slot has a long leg, a junction, and a short leg. The bolt assembly interacts with the L-shaped slot. The upper receiver has a rear e ...


9
SCREENING ASSAYS AND METHODS. February 14, 2019: US20190046944-A1

Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds t ...


10
EXCHANGE-INDUCED REMNANT MAGNETIZATION FOR LABEL-FREE DETECTION OF DNA, MICRO-RNA, AND DNA/RNA-BINDING BIOMARKERS. University of Houston System, February 14, 2019: US20190048403-A1

A method of using an exchange-induced remnant magnetization (EXIRM) technique for label free detection of short strands of nucleotides and cancer biomarkers, such as DNA and microRNA strands, DNA/RNA-binding biomarkers, and cancer-specific antigens, with high sensitivity, high specificity, and broad ...