1

2
DUAL SPECIFIC ANTIBODIES. September 8, 2016: US20160257744-A1

The invention provides dual specific antibodies and methods of making and using such antibodies. In general, the dual specific antibodies are generated by identification of a monospecific antibody having light chain variable region VL residues that are electrostatic or hydrophobic and altering the n ...


3
METHODS OF TREATING CANCERS USING PD-1 AXIS BINDING ANTAGONISTS AND TAXANES. September 8, 2016: US20160257752-A1

The invention provides methods and compositions for treating cancer and for enhancing immune function in an individual having cancer. The methods comprise administering a PD-1 axis binding antagonist and a taxane.


4
SCAFFOLD-FREE SELF-ORGANIZED 3D SYNTHETIC TISSUE. September 8, 2016: US20160256608-A1

The present invention can be used for actual implantation surgery without a scaffold. The present invention provides a synthetic tissue or complex which can be produced by culture and has a high level of differentiation ability. The present invention also provides a therapy and medicament for repair ...


5
HIGH THROUGHPUT SCREENING OF MUTAGENIZED POPULATIONS. Keygene, September 8, 2016: US20160258006-A1

Efficient methods are disclosed for the high throughput identification of mutations in genes in members of mutagenized populations. The methods comprise DNA isolation, pooling, amplification, creation of libraries, high throughput sequencing of libraries, preferably by sequencing-by-synthesis techno ...


6
INTEGRIN INTERACTION INHIBITORS FOR THE TREATMENT OF CANCER. September 8, 2016: US20160257712-A1

Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act syner ...


7
CELL-PENETRATING PEPTIDES. September 8, 2016: US20160257713-A1

The invention relates to a cell-penetrating peptide, optionally linked to a pro-apoptotic peptide, useful as pro-apoptotic agents, for inhibition of in vitro cell proliferation and for treatment of tumors.


8
ANTIBODY BINDING MICROBIAL HEPARIN BINDING MOTIF TO RETARD OR PREVENT MICROBIAL BIOFILM FORMATION ON IMPLANTED MEDICAL DEVICES. Children s Hospital Medical Center, University of Cincinnati, Yale University, September 8, 2016: US20160257734-A1

Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species and/or Staphylococcus species.


9
PLANT-ENDOPHYTE COMBINATIONS AND USES THEREFOR. September 8, 2016: US20160255844-A1

The disclosure provides materials and methods for conferring improved plant traits or benefits on plants. The materials can include a formulation comprising an exogenous endophytic bacterial population, which can be disposed on an exterior surface of a seed or seedling, typically in an amount effect ...


10
EXCISION OF TRANSGENES IN GENETICALLY MODIFIED ORGANISMS. September 8, 2016: US20160257967-A1

A method for deleting a region of DNA in a plant. In some embodiments, the method comprises transforming a plant with a nucleic acid molecule, wherein the nucleic acid molecule encodes one or more zinc finger nuclease(s) (ZFNs) operably linked to one or more tissue-specific promoter(s), e.g., a poll ...