1
Blood Biomarker for Early Blood Brain Barrier Disruption in Ischemic Stroke. STC UNM, July 16, 2015: US20150198617-A1

Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some emb ...


2
METHOD AND APPARATUS TO IMPROVE SIGNAL-TO-NOISE RATIO OF FT-IR SPECTROMETERS USING PULSED LIGHT SOURCE. July 16, 2015: US20150198482-A1

An optical spectroscopy method and apparatus increases signal to noise ratio of detected signals. Sample light passed through a sample includes attenuated light pulses and characteristic light located between the attenuated light pulses, the characteristic light formed by interaction between light p ...


3
HUMAN TISSUE KALLIKREIN 1 GLYCOSYLATION ISOFORMS. July 16, 2015: US20150196624-A1

Provided are preparations of tissue kallikrein-1 (KLK1) glycoforms having a defined number of oligosaccharide units per KLK1 molecule. Also provided are mixtures of such glycoforms, pharmaceutical compositions containing such glycoforms or mixtures thereof, methods of obtaining the rhKLK1 glycoforms ...


4
MMTV-SV40-Spy1A and Spy1A-pTRE Transgenic Mouse Models. July 16, 2015: US20150196016-A1

In one aspect, the invention provides a transgenic non-human animal model having germ cells and somatic cells containing an endogenous MMTV-SV40-Spy1A gene sequence introduced into said animal model or an ancestor of said animal model at an embryonic stage, wherein said gene sequence comprises a mou ...


5
Compositions and Methods of Treatment of Black Hemophiliac Patients. HAPLOMICS, July 16, 2015: US20150196017-A1

It has been determined that most mutations in factor VIII occur in multiple haplotypes, not primarily in one haplotype. The frequencies of mild, moderate, and severe hemophilia did not differ significantly according to the background haplotype. The odds of having inhibitor were significantly higher ...


6
Novel Microbial Succinic Acid Producers and Purification of Succinic Acid. BASF SE, July 16, 2015: US20150197776-A1

The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as wel ...


7
ENHANCED CROSS STREAM MECHANICAL THROMBECTOMY CATHETER. BOSTON SCIENTIFIC, July 16, 2015: US20150196317-A1

A thrombectomy catheter includes a catheter body having a catheter lumen. An outflow orifice is positioned along a catheter perimeter. A fluid jet emanator communicates with a high pressure tube. The fluid jet emanator includes at least one jet orifice for directing a fluid jet from the fluid jet em ...


8
APPARATUS, SYSTEM, AND METHOD FOR COLLECTING A TARGET MATERIAL. RareCyte, July 16, 2015: US20150196906-A1

This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a processing vessel, such as an Eppendorf tube, a syringe or a test tube, and a collector. The collector is sized and shaped to fit into a primary vessel, such as a te ...


9
Compositions and Methods of Treatment of Black Hemophiliac Patients. HAPLOMICS, July 16, 2015: US20150197552-A1

It has been determined that most mutations in factor VIII occur in multiple haplotypes, not primarily in one haplotype. The frequencies of mild, moderate, and severe hemophilia did not differ significantly according to the background haplotype. The odds of having inhibitor were significantly higher ...


10
Compounds. July 16, 2015: US20150197568-A1

Binding members, e.g. human antibody molecules, which bind interleukin-6 (IL-6) and neutralise its biological effects. Use of binding members for IL-6 in medical treatment e.g. for treating inflammatory diseases and tumours associated with IL-6.