21
CHAMBERLAIN STANLEY: Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections. University College Of Cardiff Consultants, Schulman B Aaron, July 15, 2010: WO/2010/081082 (19 worldwide citation)

Phosphoramidate compounds derived from guanine bases having enhanced therapeutic potency are provided, and these compounds in particular have enhanced potency with respect to treatment of viral infections, such as hepatitis C virus. Pharmaceutical compositions, methods of preparing the compounds, an ...


22
COSTELLO DONALD: Method for treating hyperglycemia with glp-1. MANNKIND CORPORATION, Cullman Louis C, July 15, 2010: WO/2010/080964 (18 worldwide citation)

A method for treating hyperglycemia and/or diabetes in a subject is provided. In particular, the method is directed for the treatment of patients with type 2 diabetes mellitus who have a fasting blood glucose concentration greater than about 8 mM, wherein the patient is administered a formulation co ...


23
VAN ALSTINE JAMES: Separation method using single polymer phase systems. GE HEALTHCARE BIO SCIENCES, Ge Healthcare Bio Sciences, July 15, 2010: WO/2010/080062 (17 worldwide citation)

The present invention relates to a process of enriching one target compound from a liquid, which process comprises at least one step of isolation performed by differentially partitioning between two aqueous phases. In the present invention the phases are formed by adding a thermally responsive, self ...


24
SCHULTZ WILLIAM J: Nanocalcite composites. 3M INNOVATIVE PROPERTIES COMPANY, Spielbauer Thomas M, July 15, 2010: WO/2010/080459 (17 worldwide citation)

Compositions comprising surface-modified nanocalcite particles dispersed in a curable resin, and to coatings and fibrous composites incorporating such compositions are described. The surface-modifying agents include a binding group ionically associated with the calcite and a compatiblizing segment, ...


25
STAGLIANO NANCY E: Modified antibody compositions, methods of making and using thereof. CYTOMX THERAPEUTICS, Roy Madhuri, July 15, 2010: WO/2010/081173 (15 worldwide citation)

The present disclosure provides modified antibodies which contain an antibody or antibody fragment (AB) modified with a masking moiety (MM). Such modified antibodies can be further coupled to a cleavable moiety (CM), resulting in activatable antibodies (AAs), wherein the CM is capable of being cleav ...


26
HAAR JR JOSEPH P: Synthesis of methylphenidate and analogs thereof. MALLINCKRODT, Siman Craig D, July 15, 2010: WO/2010/080787 (14 worldwide citation)

A synthetic process for the preparation of amino acid esters such as methylphenidate and analogs thereof is disclosed. The process involves reacting an amino acid such as α-phenyl-α-(2-piperidinyl)acetic acid or an analog thereof with an alcohol such as methanol in the presence of an acid and a wate ...


27
RANCUREL VIANNEY: Multipurpose storage system based upon a distributed hashing mechanism with transactional support and failover capability. BIZANGA, Orrick Herrington & Sutcliffe, July 15, 2010: WO/2010/080533 (14 worldwide citation)

A multipurpose storage system based upon a distributed hashing mechanism with transactional support and failover capability is disclosed. According to one embodiment, a system comprises a client system in communication with a network, a secondary storage system in communication with the network, and ...


28
LINK JOHN O: Hcv ns3 protease inhibitors. GILEAD SCIENCES, Mcgurl Barry F, July 15, 2010: WO/2010/080389 (14 worldwide citation)

The present invention relates to macrocyclic compounds of formula (Ia) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.


29
DIMARCHI RICHARD D: Amide-based insulin prodrugs. INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION, Breen John P, July 15, 2010: WO/2010/080609 (13 worldwide citation)

Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half lives of at least 10 hours, and more typically greater than 2 hours, 20 hours and l ...


30
GOROKHOV ALEXEI Y: Semi-static resource allocation to support coordinated multipoint (comp) transmission in a wireless communication network. QUALCOMM INCORPORATED, Corie Florin C, July 15, 2010: WO/2010/081166 (12 worldwide citation)

Techniques for supporting Coordinated MultiPoint (CoMP) transmission are described. For CoMP transmission, multiple cells may simultaneously send one or more data streams to one or more UEs on the same time-frequency resources based on short-term channel feedback from at least one UE to at least two ...