41
Rosanne M Crooke, Mark J Graham: Modulation of apolipoprotein (a) expression. Isis Pharmaceuticals, Jones Day, June 22, 2010: US07741305 (77 worldwide citation)

Compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein(a). Methods of using these compounds for modulation of apolipoprotein(a) expression and for diagnosis and ...


42
Neil L Anderson, Evan Chong: Ablation catheter. Cathrx, Morrison & Foerster, June 22, 2010: US07740629 (75 worldwide citation)

An ablation catheter 10 includes an elongate carrier 12. A first loop 14.1 is arranged at, or adjacent, a distal end of the carrier 12. At least one sensing electrode 40 is carried on the first loop 14.1 for sensing irregular electrical activity in a patient's body. At least one further loop 14.2 is ...


43
Gopal Parupudi, Stephen S Evans, Burdette J Holtgrewe, Edward F Reus: Context aware systems and methods utilizing hierarchical tree structures. Microsoft Corporation, Lee & Hayes PLLC, June 22, 2010: US07743074 (75 worldwide citation)

Context-aware computing systems and methods are described. In particular embodiments, location aware systems and methods are described. In the described embodiments, hierarchical tree structures are utilized to ascertain a device context or location. The tree structures can be stored on or accessibl ...


44
Jeffrey Lange, Kenneth Charles Baron, Charles Walden, Marcus Harte: Enhanced parimutuel wagering. Longitude, Kenyon & Kenyon, June 22, 2010: US07742972 (74 worldwide citation)

Methods and systems for engaging in enhanced parimutuel wagering and gaming. In one embodiment, different types of bets can be offered and processed in the same betting pool on an underlying event, such as a horse or dog race, a sporting event or a lottery, and the premiums and payouts of these diff ...


45
Jens Bo Rode Hansen, Charlotte Albaek Thrue, Majken Westergaard, Kamille Dumong Petersen, Margit Wissenbach: Oligomeric compounds for the modulation of survivin expression. Santaris Pharma, Dechert, June 22, 2010: US07741309 (73 worldwide citation)

Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the survivin. Methods of using these compounds for modulation of survivi ...


46
John A Hibner: Biopsy device with sample storage. Ethicon Endo Surgery, June 22, 2010: US07740596 (72 worldwide citation)

A biopsy device and method are provided for obtaining and storing multiple tissue samples. The device permits the tissue samples to be stored in an end to end configuration. The device can include a sample tube having a sample lumen and a generally parallel vacuum lumen. A movable member, such as ro ...


47
Pierre Lebreton: Cross-linking of low and high molecular weight polysaccharides preparation of injectable monophase hydrogels and polysaccharides and hydrogels thus obtained. Allergan Industrie SAS, Linda A Fox, Allergan, June 22, 2010: US07741476 (72 worldwide citation)

A process for the crosslinking of at least one polymer selected from polysaccharides and derivatives thereof, which is carried out in an aqueous solvent by the action of an effective and non-excessive amount of at least one crosslinking agent, characterized in that it is carried out on a mixture con ...


48
Takayuki Inoue, Yoshiyuki Kurokawa, Takayuki Ikeda: Semiconductor device and electronic device. Semiconductor Energy Laboratory, Fish & Richardson P C, June 22, 2010: US07742351 (70 worldwide citation)

In relation to reading of data in a memory, it is an object to provide a semiconductor device mounted with a low power consumption memory. A semiconductor device including a word line, a bit line, and a memory cell electrically connected to the word line and the bit line, further includes a precharg ...


49
Alon Konchitsky, William Martin Ribble: Environmental noise reduction and cancellation for a communication device including for a wireless and cellular telephone. Alon Konchitsky, Steven A Nielsen, Allman & Nielsen PC, June 22, 2010: US07742790 (68 worldwide citation)

Various embodiments of the present invention enable a system and method for reducing or entirely canceling background or environmental noise from a voice transmission from a communications device. A communications device, such as a mobile telephone, is configured with an environmental noise compensa ...


50
Sara S Hadida Ruah, Matthew Hamilton, Mark Miller, Peter D J Grootenhuis, Brian Bear, Jason McCartney, Jinglan Zhou: Modulators of ATP-binding cassette transporters. Vertex Pharmaceuticals Incorporated, Michael J DiVerdi, June 22, 2010: US07741321 (68 worldwide citation)

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods ...