1
Nils Lonberg, Robert M Kay: Ransgenic non-human animals for producing heterologous antibodies. GenPharm International, Townsend & Townsend & Crew, August 13, 1996: US05545806 (1042 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppressed by antisense polynucleotides and/or b ...


2
Azim M Surani, Michael S Neuberger, Marianne Bruggemann: Production of antibodies from transgenic animals. The Babraham Institute, Medical Research Council, Cushman Darby and Cushman, August 13, 1996: US05545807 (855 worldwide citation)

Chimaeric or wholly foreign immunoglobulin is obtained from cells or body fluid of a transgenic animal which has had inserted into its germline genetic material that encodes for at least part of an immunoglobulin, of foreign origin or that can rearrange to encode a repertoire of immunoglobulins, i.e ...


3
Walter H Olson, William F Kaemmerer: Prioritized rule based method and apparatus for diagnosis and treatment of arrhythmias. Medtronic, Reed A Duthler, Harold R Patton, August 13, 1996: US05545186 (609 worldwide citation)

An implantable antiarrhythmia device which detects and classifies arrhythmias of the human heart, and delivers appropriate therapy. The device employs a method of arrhythmia classification based on a set of prioritized rules, each of the rules defining a plurality of criteria based upon characterist ...


4
Kenneth Kensey, John E Nash, Douglas Evans: System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating. Kensey Nash Corporation, Caesar Rivise Bernstein Cohen & Pokotilow, August 13, 1996: US05545178 (608 worldwide citation)

A system and method for sealing a percutaneous puncture extending into internally located tissue, e.g., the peritoneum, of a living being. The system includes a sealing device and a deployment instrument. In one embodiment the sealing device comprises a substantially rigid anchor, a resorbable holdi ...


5
John H Stevens: Endovascular aortic valve replacement. Heartport, Townsend and Towsend and Crew, August 13, 1996: US05545214 (568 worldwide citation)

The subject invention relates to a valve replacement system together with methods of preparation and use, are provided for endovascular replacement of a heart valve in a host. The valve replacement system includes up to five components: (1) a prosthetic valve device, (2) a valve introducer device, ( ...


6
Daniel David, Zipora David: Ambulatory patient health monitoring techniques utilizing interactive visual communication. Cardiomedix, Banner & Allegretti, August 13, 1996: US05544649 (544 worldwide citation)

An ambulatory (in the home) patient health monitoring system is disclosed wherein the patient is monitored by a health care worker at a central station, while the patient is at a remote location. The patient may be a person having a specific medical condition monitored or may be an elderly person de ...


7
Mir A Imran: Catheter for RF ablation having cooled electrode with electrically insulated sleeve. Cardiac Pathways Corporation, Flehr Hohbach Test Albritton & Herbert, August 13, 1996: US05545161 (514 worldwide citation)

A catheter for radio frequent ablation of tissue which includes a flexible elongate member having proximal and distal extremities. The flexible elongate member is provided with a lumen in the distal extremity. A metal conducting electrode is secured to the distal extremity of the elongate member and ...


8
Charles L Davis, Paul V Long: Real time ambulatory patient monitor. Charles L Davis, Marger Johnson McCollom & Stolowitz P C, August 13, 1996: US05544661 (511 worldwide citation)

A patient monitoring system which includes a portable device and a central station. The portable device includes an ECG and a photo-plethysmograph connected to the patient; arrhythmia analysis apparatus; an expert system for determining if a pre-established critical parameter set has been exceeded; ...


9
George T Roberts, Kathleen L Hess, Sepideh H Nott, Michael S H Chu, Yem Chin: Controlled deployment of a medical device. Texas Petrodet, Bush Moseley Riddle & Jackson, August 13, 1996: US05545209 (450 worldwide citation)

A prosthesis delivery system having a balloon catheter with an inflatable balloon on its exterior. The balloon is inflatable by injection of fluid through a lumen in the catheter and the balloon is initially partially constrained against inflation by a constraint. A tubular prosthesis is disposed on ...


10
Scott H West, Frank Nguyen: Steerable electrophysiology catheter. Medtronic Cardiorhythm, Townsend and Townsend and Crew, August 13, 1996: US05545200 (423 worldwide citation)

An electrophysiology catheter (20) comprises a shaft (22) having a first bending stiffness and a deflectable tip (28) secured to the distal end (24) of the shaft with a second bending stiffness less than the first bending stiffness. At least one electrode (34, 36) is mounted to the tip for deliverin ...