Queen Cary L, Selick Harold Edwin: Chimeric immunoglobulins specific for p55 tac protein of the il-2 receptor.. Protein Design Labs, October 16, 1991: EP0451216-A1 (153 worldwide citation)

Novel methods for designing humanized immunoglobulins having one or more complementary determining regions (CDR's) from a donor immunoglobulin and a framework region from a human immunoglobulin comprising first comparing the framework or variable region amino acid sequence of the donor immunoglobuli ...

Fischer Hans Joachim Dr Ing, Kranz Curt Dr Ing, Sauer Guenther Dr Ing: Bone screw.. Mecron Med Prod, October 16, 1991: EP0451932-A1 (139 worldwide citation)

Bone screw (1) formed of a material which is resorbable by the body comprising a recess (5) for the introduction of an insertion tool (8) whose cross-section is non-circular and suited for the transferral of torque, characterised in that the recess (5) for the introduction of the insertion tool (8) ...

Coleman James David, Smith Anthony Gregory, Byrne William Anthony, Spokes Duncan Nigel: Flue gas extraction. S &Amp, C Thermofluids, Wonderfire, October 16, 1991: GB2242935-A (90 worldwide citation)

Flue gases entering at 10 are drawn from a gas appliance by means of a ducted Coanda effect flue system. Motive air is supplied at 9 from a remote pump. In this way the hot and corrosive gases do not come into contact with rotating fan parts. Various nozzle modifications are envisaged.

Lazareth Michel, Lecorre Noel: Driving mechanism for circuit breaker.. Merlin Gerin, October 16, 1991: EP0452230-A1 (89 worldwide citation)

The mechanism (10) of a miniature circuit-breaker includes a bistable indicator (50) mounted in free rotation on the axle (42) of the handle (18) between an active position and an inactive position. The indicator (50) comprises a first signalling arm (52) fitted with an indicator light (54), and a s ...

Greve Henri Marcel Jozef de, Salgado Maria Benita Leonor Fernandez, Montagu Marc Charles Ernest Van, Vaeck Mark Albert, Zabeau Marcus Florent Oscar, Leemans Jan Jozef August, Hofte Hermanus Fransiscus Paul: Modifying plants by genetic engineering to combat or control insects.. Plant Genetic Systems, October 16, 1991: EP0451878-A1 (81 worldwide citation)

Novel transformation vectors containing novel chimeric genes allow the introduction of exogenous DNA fragments coding for polypeptide toxins produced by Bacillus thuringiensis or having substantial sequence homology to a gene coding for a polypeptide toxin as described herein and expression of the c ...

Wirak Dana O, Bayney Richard, Ramabhadran Triprayer V, Unterbeck Axel, Rae Peter, Scangos George: Recombinant app minigenes for expression in transgenic mice as models for alzheimerss disease.. Miles, October 16, 1991: EP0451700-A1 (75 worldwide citation)

Functional recombinant APP minigene constructs and their introduction into the germline of transgenic mice. Such transgenic mice are useful to generate models of Alzheimer's disease and pathogenesis and are also useful to identify molecular mechanisms of the pathogenesis of Alzheimer's disease.

Tansley Robert William, Gibbs Andrew, Macmahon Alistair John, Ferguson James, Bentley Andrew Charles, King Christine Anne, Newman Alec Thomas: Packages containing comestibles.. Gen Foods Kraft, October 16, 1991: EP0451980-A2 (63 worldwide citation)

A sealed package containing one or more powder, paste or liquid comestible preparation ingredients and being formed from substantially air- and water-impermeable materials, the said package comprising a compartment (2) containing the said one or more comestible preparation ingredients, an inlet (12) ...

Anderson Paul J, Carlson Thomas C, Jessen Ross A, Matuska Dennis D, Jones Richard E, Walter Bert: Disposable reagent unit.. Cascade Medical, October 16, 1991: EP0451981-A2 (57 worldwide citation)

A disposable reagent unit including a base strip (12) with a plurality of spaced holes (14,16), a double face tape (32), a reagent (36) and a lot identification paper (34) in a side-by-side adjacent relationship, a wick (30), and a cover strip (26) with a hole (20) for engagement with a diagnostic i ...

Nagafuzi Norboru, Tsukada Takayuki, Shima Kazuhiro, Takagishi Yasushi, Suzuki Yusuke, Tomoda Yoshitaka, Hayashi Takashi: Coated composition and its preparation process.. Shionogi & Co, October 16, 1991: EP0452145-A2 (55 worldwide citation)

A process for preparing a coated composition comprising a pharmaceutically active substance stable to heat, which comprises centrifugally granualting a mixture comprising said active substance and a first thermomelting material as a binder under heating without using any solvent and coating the resu ...

Brzeczko Albert Walter, Nibbelink Donald Wilfred, Mollica Joseph A: Deprenyl/l-dopa/carbidopa pharmaceutical composition.. Du Pont Merck Pharma, October 16, 1991: EP0451484-A1 (54 worldwide citation)

Disclosed are pharmaceutical combination products useful for the treatment of Parkinson's disease. These products are based on a combination of active ingredients which are carbidopa, levodopa, and deprenyl in a pharmaceutical carrier, preferably a carrier wherein one or more of the active ingredien ...