1
Brantigan John W: Surgical prosthetic implant.. Brantigan John W, March 15, 1989: EP0307241-A2 (261 worldwide citation)

Prosthetic plug implants (11,31-34,111) forming side-by-side transverse struts between adjacent vertebrae having roughened surfaces (11b,31b,32b,34d,122) receiving bone ingrowth to fuse the plugs on prepared surface sites (15,115) on opposed faces of adjacent vertebrae and have end faces (11a,31a,34 ...


2
Mather Jennie P, Ullrich Axel: A method for culturing recombinant cells.. Genentech, March 15, 1989: EP0307247-A2 (117 worldwide citation)

A method for culturing a recombinant host cell comprising: determining a polypeptide factor for a polypeptide factor-dependent host cell; transforming said host cell with nucleic acid encoding said polypeptide factor; transforming the host cell with nucleic acid encoding a desired protein; and, cult ...


3
Montalescot Jean Bernard, Camus Guy, Lucas Jean: Automatic milking machine.. Cemagref, March 15, 1989: EP0306579-A1 (111 worldwide citation)

The co-ordinates of the teats of an animal in a stall (11) are measured by means of a co-ordinate-measuring device having a general sensor such as a camera arranged in a fixed location on one side of the stall and connected to scanning means for forming an image of the animal's teats, and means for ...


4
Baker Raymond, Saunders John, Macleod Angus M, Merchant Kevin: Thiadiazoles useful in the treatment of senile dementia.. Merck Sharp & Dohme, March 15, 1989: EP0307142-A1 (96 worldwide citation)

A class of novel thiadiazoles, substituted on one of the ring carbon atoms with a non-aromatic azacyclic or azabicyclic ring system, and substituted on the other ring carbon atom with a substituent of low lipophilicity, or a hydrocarbon substituent; are potent muscarinic agonists, and have good CNS ...


5
Holmquist Fredrik: Optical navigation system for an automatic guided vehicle, and method.. Netzler & Dahlgren Ing Firman, March 15, 1989: EP0307381-A2 (68 worldwide citation)

A navigation system for guiding an automatically guided vehicle having vehicle control means along a variable, pre-determined path defined by a plurality of fixed, spaced-apart points, A target positioned at each spaced-apart point defining the vehicle path, said target including a first light sourc ...


6
Sivam Gowsala: Immunconjugates joined by thioether bonds having reduced toxicity and improved selectivity.. Neorx, March 15, 1989: EP0306943-A2 (68 worldwide citation)

Method for producing an immunoconjugate comprising the steps of reacting a toxin or protein with a heterobifunctional reagent having the following general formula: where R1 is: -(CH2)n- or where n = 1 to 10; and where R2 is selected from the group consisting of o- and p-nitrophenyl, 2-chloro-4-nitro ...


7
Sugiyama Takashi, Masuda Kenichi, Tajima Yoshitaka, Yonemura Hiroshi: Process for producing recombinant human factor viii:c.. Chemo Sero Therapeut Res Inst, Teijin, March 15, 1989: EP0306968-A2 (48 worldwide citation)

A transformant of animal cells , preferably CHO cells,is described which is produced by transforming animal cells with an expression vector containing a gene encoding natural type active human Factor VIII:C and upstream thereof at least one promoter and optionally containing further at least one enh ...


8
Roger Fu Cherng Chyi, Lidgate Deborah M: Preservative system for ophtalmic formulations.. Syntex, March 15, 1989: EP0306984-A1 (46 worldwide citation)

Stable, clear, antimicrobially effective, ophthalmic formulations include an ophthalmologically effective amount of a drug, especially a -COOH group-containing drug or a NSAID, and a preservative system formed of a quaternary ammonium preservative and a nonionic surfactant, all in an aqueous vehicle ...


9
Gordon Julian, Pugh Charles Stuart Gredell: Lateral flow chromatographic binding assay device.. Abbott Lab, March 15, 1989: EP0306772-A1 (43 worldwide citation)

The present invention relates to improved specific binding assay devices comprising a chromatographic medium including a reaction site at which a specific binding reagent is immobilized, a sample application means located adjacent to said chromatographic medium and offset upstream from said reaction ...


10
Long David M Jr: Fluorocarbon emulsions for in vivo use.. Long David M Jr, March 15, 1989: EP0307087-A1 (38 worldwide citation)

Fluorocarbon emulsions for use in or with animal bodies and organs thereof, maintains emulsion stability through normal sterilization procedures with selective osmotic and buffering agents, maintains the emulsion at within predetermined osmolarity levels and, when desired, free of excessive calcium ...