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BAURIN Nicolas, BEIL Christian, CORVEY Carsten, LANGE Christian, LI Danxi, MIKOL Vincent, STEINMETZ Anke, RAO Ercole: PROTÉINES DE LIAISON À DES ANTICORPS-LIKE À DOUBLE RÉGION VARIABLE AYANT UNE ORIENTATION CROISÉE DE RÉGION DE LIAISON, DUAL VARIABLE REGION ANTIBODY-LIKE BINDING PROTEINS HAVING CROSS-OVER BINDING REGION ORIENTATION. SANOFI, BAURIN Nicolas, BEIL Christian, CORVEY Carsten, LANGE Christian, LI Danxi, MIKOL Vincent, STEINMETZ Anke, RAO Ercole, ZUHN Donald L, October 4, 2012: WO/2012/135345 (5 worldwide citation)

The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a cross- over orientation. The invention also provides meth ...


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Shen Wenyan, Graham Kevin, Winters Katherine Ann, Veniant Ellison Murielle, Boone Thomas Charles: Glp-1 compound/glucagon antibody compositions. Amgen, Shen Wenyan, Graham Kevin, Winters Katherine Ann, Veniant Ellison Murielle, Boone Thomas Charles, ZUHN Donald L Jr, November 1, 2007: WO/2007/124463 (3 worldwide citation)

Compositions comprising antibodies that bind glucagon linked to GLP-I compounds are provided, as well as methods of using the compositions for treating, for example, metabolic disorders, enhancing insulin expression, and promoting insulin secretion in a subject.


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Fox Gary M, Sullivan John K, Fang Mei: B7-like molecules and uses thereof. Amgen, Fox Gary M, Sullivan John K, Fang Mei, ZUHN Donald L, January 10, 2002: WO/2002/002624 (3 worldwide citation)

The present invention provides B7-Like(B7-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing B7-L polypeptides. The invention further provides pharmaceutical compositions and methods for t ...


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CHENCHIK ALEX: Reagents and methods for producing bioactive secreted peptides. ROSWELL PARK CANCER INSTITUTE, Zuhn Donald L Jr, November 11, 2010: WO/2010/129310 (3 worldwide citation)

This invention discloses reagents and methods for identifying peptides that modulate biological activities in cells, tissues, organs and organisms.


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Paszty Christopher J: Wnt-1 inhibitory factor-1 (wif-1) molecules and uses thereof. Amgen, Paszty Christopher J, ZUHN Donald L, July 15, 2004: WO/2004/058949 (1 worldwide citation)

The present invention provides Wnt-1 Inhibitory Factor-1 (WIF-1) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing WIF-1 polypeptides. The invention further provides pharmaceutical compositi ...


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Dent Thomas, Hush Theresa, Aube William M: System and method for providing remote users with reports and analyses based on user data and adaptable reporting with the ability to alter, modify or augment such reports and analyses through web-based technology. Iclops, Dent Thomas, Hush Theresa, Aube William M, ZUHN Donald L, August 28, 2008: WO/2008/103749 (1 worldwide citation)

A system and method for providing remote users with reports and analyses based on user data is disclosed. One such report is a physician score report that includes a physician score. The physician score is determined by analyzing data from multiple data sources. Another such report displays the stat ...


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BEHLKE Mark Aaron, OWCZARZY Richard, YOU Yong, WALDER Joseph Alan, LENNOX Kim: MODIFICATIONS POUR COMPOSÉS ANTISENS, MODIFICATIONS FOR ANTISENSE COMPOUNDS. INTEGRATED DNA TECHNOLOGIES, BEHLKE Mark Aaron, OWCZARZY Richard, YOU Yong, WALDER Joseph Alan, LENNOX Kim, ZUHN Donald L, March 15, 2012: WO/2012/033848 (1 worldwide citation)

The invention pertains to modifications for antisense oligonucleotides, wherein the modifications are used to improve stability and provide protection from nuclease degradation. The modifications could also be incorporated into double-stranded nucleic acids, such as synthetic siRNAs and miRNAs.


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ZHU FU GANG: Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (iro) antagonists of tlr7 and tlr9. IDERA PHARMACEUTICALS, Zuhn Donald L Jr, December 9, 2010: WO/2010/141483 (1 worldwide citation)

The invention provides the use of immune regulatory oligonucleotides (IRO) as antagonist of TLRs and potentiators of anti-inflammatory agents that inhibit TNF for the prevention and treatment of inflammatory and autoimmune diseases.


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Ji Jay: Internal control in situ hybridization. Ventana Medical Systems, Ji Jay, ZUHN Donald L, November 17, 2005: WO/2005/107430 (1 worldwide citation)

The invention provides a method for monitoring the quality of in situ hybridization analysis of a nuclear DNA target in a tissue or cell sample using a mitochondrial DNA probe as an internal control. The invention also provides a reagent for in situ hybridization detection of a nuclear DNA target an ...