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Kevin Rodzinak
Philip E Sanderson, Mark E Layton, Kevin J Rodzinak: Inhibitors of AKT activity. Merck Sharp & Dohme, Matthew A Leff, Yong Zhao, David A Muthard, May 1, 2012: US08168652 (3 worldwide citation)

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt ...


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Vincent J Colandrea, George A Doherty, Jeffrey J Hale, Pei Huo, Irene E Legiec, Leslie Toth, Petr Vachal, Lin Yan: (3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists. Merck & Co, Yong Zhao, Valerie J Camera, October 20, 2009: US07605171 (12 worldwide citation)

The present invention encompasses compounds of Formula I: as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activities by modulating leukocyte trafficking, sequestering lymphocytes ...


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Robert L Bugianesi, George A Doherty, Amy Gentry, Jeffrey J Hale, Christopher L Lynch, Sander G Mills, William E Neway III: Edg receptor agonists. Merck & Co, Yong Zhao, Valerie J Camara, January 20, 2009: US07479504 (9 worldwide citation)

The present invention encompasses compounds of Formula 1: as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and ...


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Jinlong Jiang, Robert J DeVita, Sanjeev Kumar, Sander G Mills, Richard A Tschirret Guth: Hydroisoindoline tachykinin receptor antagonists. Merck Sharp & Dohme, Yong Zhao, Valerie J Camara, March 23, 2010: US07683068 (8 worldwide citation)

The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingr ...


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Leonid Beigelman, Jasenka Matulic Adamic: Conjugates and compositions for cellular delivery. Sirna Therapeutics, Yong Zhao, David A Muthard, May 29, 2012: US08188247 (7 worldwide citation)

This invention features conjugates, compositions, methods of synthesis, and applications thereof, including folate derived conjugates of nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids and antisense nucleic acid molecules.


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Amjad Ali, James M Balkovec, Donald W Graham, Christopher F Thompson, Nazia Quraishi: 1H-benzo[F]indazol-5-YL derivatives as selective glucocorticoid receptor modulators. Merck & Co, Yong Zhao, Valerie J Camara, December 1, 2009: US07625937 (7 worldwide citation)

The present invention encompasses compounds of Formula I: or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of u ...


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Keith M Gottesdiener, Stuart A Green, Euan MacIntyre: Merck Sharp & Dohme, Yong Zhao, Valerie J Camaro, February 22, 2011: US07893091 (7 worldwide citation)

This invention concerns compositions for the treatment of urinary frequency, urinary urgency and urinary incontinence comprising (R)-N-[4-[2-[[2-hydroxy-2-(pyridin-3 -yl)ethyl]amino]ethyl]phenyl]-4-[4-(4-trifluoromethylphenyl)thiazol-2-yl]benzenesulfonamide and pharmaceutically acceptable salts ther ...


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Robert J DeVita, Sander G Mills, Jinlong Jiang, Andrew J Kassick, Jianming Bao: Hydroxymethyl ether hydroisoindoline tachykinin receptor antagonists. Merck Sharp & Dohme, Yong Zhao, Valerie J Camara, February 28, 2012: US08124633 (6 worldwide citation)

The present invention is directed to certain hydroxymethyl ether hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these comp ...


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Jasenka Matulic Adamic, Leonid Beigelman: Conjugates and compositions for cellular delivery. Sirna Therapeutics, Yong Zhao, David A Muthard, June 11, 2013: US08461313 (6 worldwide citation)

This invention features conjugates, compositions, methods of synthesis, and applications thereof, including folate derived conjugates of nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids and antisense nucleic acid molecules.



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