51
Hugh R Sharkey, Joel Saal, Jeffrey A Saal, John Ashley: Method for treating intervertebral disc degeneration. Oratec Interventions, Wilson Sonsini Goodrich & Rosati, August 1, 2000: US06095149 (266 worldwide citation)

A percutaneous method treats degenerate disc disease characterized by a circumferential bulge. The method provides a catheter having a distal end, a proximal end, and a longitudinal axis, the distal end having an intradiscal section with at least one energy delivery device. The next step is applying ...


52
Edward J Gough, Alan A Stein: Multiple antenna ablation apparatus and method with cooling element. Rita Medical Systems, Wilson Sonsini Goodrich & Rosati, September 22, 1998: US05810804 (266 worldwide citation)

An ablation apparatus includes a handpiece, an electrode extending from a handpiece distal end, a probe, a thermal sensor and an energy source. The electrode includes a distal end and a lumen, a cooling medium inlet conduit and a cooling medium exit conduit. Both conduits extend through the electrod ...


53
Stuart D Edwards: Method for ablating interior sections of the tongue. Sommus Medical Technologies, Wilson Sonsini Goodrich & Rosati, September 1, 1998: US05800379 (265 worldwide citation)

A method for reducing a volume of a tongue provides an ablative agent source. The ablative agent source is coupled to an ablative agent delivery device. At least a portion of the ablative agent delivery device is advanced into an interior of the tongue. A sufficient amount of an ablative agent is de ...


54
Elizabeth A Holmes, Shaunak Roy, John Howard, Chengwang Wang: Medical device for analyte monitoring and drug delivery. Theranos, Wilson Sonsini Goodrich & Rosati, November 6, 2007: US07291497 (265 worldwide citation)

The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therape ...


55
Franklin R Koenig, Bruno Strul, Robin Bek: Linear power control with digital phase lock. Somnus Medical Technologies, Wilson Sonsini Goodrich & Rosati, October 31, 2000: US06139546 (261 worldwide citation)

A method and apparatus for delivery of energy by an electro-surgical instrument to a surgical site is disclosed. The apparatus delivers power to electrodes of an electro-surgical instrument during an operation performed at a surgical site. The apparatus includes a processor and a plurality of power ...


56
James Baker: RF method for controlled depth ablation of soft tissue. Oratec Interventions, Wilson Sonsini Goodrich & Rosati, July 28, 1998: US05785705 (261 worldwide citation)

An RF ablation apparatus has a delivery catheter with a delivery catheter lumen and a delivery catheter distal end. A first RF electrode is positioned in the delivery catheter lumen. The first RF electrode has a distal end, RF conductive surface, and a lumen. A second RF electrode has a distal end. ...


57
Edward W Knowlton: Apparatus for controlled contraction of collagen tissue. Thermage, Wilson Sonsini Goodrich & Rosati, May 14, 2002: US06387380 (261 worldwide citation)

A method and apparatus applies radiant energy through the skin to an underlying subcutaneous layer or deeper soft tissue layers that includes loculations of fat with fibrous septae made of collagen tissue. This creates a desired contour effect without substantially modifying melanocytes and other ep ...


58
Hugh R Sharkey, John Ashley, Joel Saal, Jeffrey A Saal, Le Trong Le: Method and apparatus for delivering or removing material from the interior of an intervertebral disc. Oratec Interventions, David J Wilson Sonsini Goodrich & Rosati Weitz, August 8, 2000: US06099514 (257 worldwide citation)

An externally guidable intervertebral disc apparatus manipulates disc tissue present at a selected location of an intervertebral disc, comprising a catheter having a distal end, a proximal end, and a longitudinal axis, the catheter having an intradiscal section at the distal end of the catheter, the ...


59
Edward W Knowlton: Method and apparatus for controlled contraction of collagen tissue. Thermage, Paul Davis Wilson Sonsini Goodrich & Rosati, September 17, 2002: US06453202 (256 worldwide citation)

A method and apparatus applies radiant energy through the skin to underlying collagen tissue without substantially modifying melanocytes and other epithelial cells in the epidermis. A porous membrane is adapted to receive an electrolytic solution and become inflated to substantially conform a contac ...


60
Kenneth J Livak, Susan J A Flood, Jeffrey Marmaro, Khairuzzaman Bashar Mullah: Self-quenching fluorescence probe. Perkin Elmer Corporation, Wilson Sonsini Goodrich & Rosati, March 3, 1998: US05723591 (253 worldwide citation)

An oligonucleotide probe is provided which includes a fluorescent reporter molecule and a quencher molecule capable of quenching the fluorescence of the reporter molecule. The oligonucleotide probe is constructed such that the probe exists in at least one single-stranded conformation when unhybridiz ...