1
Woolf Clifford, D Urso Donatella, Befort Katia, Costigan Michael: Nucleic acid and amino acid sequences involved in pain. The General Hospital Corporation, Bayer, Woolf Clifford, D Urso Donatella, Befort Katia, Costigan Michael, WILLIAMS Kathleen Madden, February 27, 2003: WO/2003/016475 (7 worldwide citation)

The present invention relates to nucleic acid sequences which are related to pain and which are differentially expressed during pain. The invention further relates to methods of identifying nucleic acid sequences which are differentially expressed during pain, microarrays comprising such differentia ...


2
Lu Kun Ping, Zhou Xiao Zhen: Novel telomerase inhibitors and uses therefor. Beth Israel Deaconess Medical Center, Lu Kun Ping, Zhou Xiao Zhen, WILLIAMS Kathleen Madden, November 21, 2002: WO/2002/092765

The present invention provides molecules including Pin2 and telomerase binding polypeptides, polynucleotides encoding such polypeptides, and antibodies specifically immunoreactive to said polypeptides. The invention also provides methods for screening agents which modulate the function or expression ...


3
Hogrefe Holly Hurlbut, Cline Janice Marie: Compositions and methods for random nucleic acid mutagenisis. Stratagene, Hogrefe Holly Hurlbut, Cline Janice Marie, WILLIAMS Kathleen Madden, December 5, 2002: WO/2002/097078

The invention relates to compositions and methods for nucleic acid PCR mutagenisis using novel error-prone DNA polymerases and a PCR enhancing factor. The invention also relates to compositions and methods for nucleic mutagenesis with two or more DNA polymerases lacking or exhibiting reduced exonucl ...


4
Sorge Joseph A, Mullinax Rebecca Lynn, Novoradovsky Alexey: Compositions and methods comprising control nucleic acid. Stratagene, Sorge Joseph A, Mullinax Rebecca Lynn, Novoradovsky Alexey, WILLIAMS Kathleen Madden, February 27, 2003: WO/2003/016550

The present invention relates, in part, to control nucleic acid molecules having no significant sequence homology to any known nucleic acid, and predefined G/C-content. The present invention further relates to method of using control nucleic acid molecules to validate microarray analyses, compositio ...


5
Hogrefe Holly, Borns Michael, Sorge Joseph A: High fidelity dna polymerase compositions and uses therefor. Stratagene, Hogrefe Holly, Borns Michael, Sorge Joseph A, WILLIAMS Kathleen Madden, July 24, 2003: WO/2003/060144

The subject invention relates to compositions comprising an enzyme mixture which comprises a first enzyme and a second enzyme; where the first enzyme comprises a DNA polymerization activity and the second enzyme comprises an 3'-5' exonuclease activity and a reduced DNA polymerization activity. The i ...


6
Habener Joel F, Zulewski Henryk, Thomas Melissa K, Abraham Elizabeth J, Vallejo Mario, Leech Colin A, Nolan Anna Louise, Lechner Andreas: Stem cells of the islets of langerhans and their use in treating diabetes mellitus. The General Hospital Corporation, Habener Joel F, Zulewski Henryk, Thomas Melissa K, Abraham Elizabeth J, Vallejo Mario, Leech Colin A, Nolan Anna Louise, Lechner Andreas, WILLIAMS Kathleen Madden, April 3, 2003: WO/2003/026584

Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing beta cells, as well as hepatocytes. ...