1
Richard L Monaghan, Alfred W Alberts, Carl H Hoffman, George Albers Schonberg: Hypocholesteremic fermentation products and process of preparation. Merck & Co, William H Nicholson, Harry E Westlake Jr, November 4, 1980: US04231938 (266 worldwide citation)

Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise a compound designated MSD803 which has the lactone structure: ##STR1## as well as its free hydroxy acid form. Together with salts and esters of the free acid form, these compounds ...


2
William F Hoffman, Robert L Smith, Alvin K Willard: Antihypercholesterolemic compounds. Merck & Co, William H Nicholson, Mario A Monaco, April 24, 1984: US04444784 (222 worldwide citation)

6(R)-[2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl]-4 (R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones are prepared by acylation of the corresponding 8'-hydroxy compounds. The products are strong inhibitors of the biosynthesis of cholesterol.


3
Claude Mazuel, Marie Claire Friteyre: Ophthalmological composition of the type which undergoes liquid-gel phase transition. Merck & Co, William H Nicholson, Joseph F DiPrima, August 29, 1989: US04861760 (150 worldwide citation)

The present invention relates to a pharmaceutical composition intended for contacting with a physiological liquid characterized in that said composition is intended to be administered as a non-gelled liquid form and is intended to gel in situ, this composition containing at least one polysaccharide ...


4
William F Hoffman, Robert L Smith, Alvin K Willard: Antihypercholesterolemic compounds. Merck & Co, William H Nicholson, Mario A Monaco, May 22, 1984: US04450171 (119 worldwide citation)

6(R)-[2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H- pyran-2-ones are prepared by acylation of the corresponding 8'-hydroxy compounds. The products are strong inhibitors of the biosynthesis of cholesterol.


5
Robert E Dempski, Gunvant N Mehta, Joseph C Saboe: Sustained release indomethacin. Merck & Co, William H Nicholson, Mario A Monaco, November 6, 1979: US04173626 (103 worldwide citation)

A sustained release indomethacin pharmaceutical product is provided that utilizes a pellet formulation encapsulated in a hard gelatin capsule. A portion of the pellets is uncoated for immediate and rapid release of indomethacin for elevating the plasma level. The remainder of the pellets are coated ...


6
Alvin K Willard, Frederick C Novello, William F Hoffman, Edward J Cragoe Jr: Substituted pyranone inhibitors of cholesterol synthesis. Merck & Co, William H Nicholson, Mario A Monaco, March 1, 1983: US04375475 (97 worldwide citation)

6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.


7
William J Greenlee, Dooseop Kim, Nathan B Mantlo, Arthur A Pastchett, Ralph A Rivero: 6-amino substituted imidazo[4,5-bipyridines as angiotensin II antagonists. Merck & Co, Joseph F DiPrima, William H Nicholson, Valerie J Camara, June 29, 1993: US05223499 (74 worldwide citation)

Substituted imidazo[4,5-b]pyridines of structural formula: ##STR1## are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.


8
Paul Henault, Carleton H Macartney, Gilbert Lataix, Ronald G Saffron: Dual chambered mixing and dispensing vial. Merck & Co, William H Nicholson, Joseph F DiPrima, August 21, 1990: US04950237 (61 worldwide citation)

A dual chambered vial is equipt with a dislodgeable stopper device between the two chambers, whereby components of a mixture may be maintained in separate chambers until comingling is desired. The stopper is dislodged by means of a plunger activated by depression of flexible walls of one chamber.


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Kenneth A Thomas Jr: Purification and characterization of a protein fibroblast growth factor. Merck & Co, William H Nicholson, Mario A Monaco, April 24, 1984: US04444760 (53 worldwide citation)

Acidic brain fibroblast growth factor isolated from bovine brain, is purified by a particular combination of protein purification techniques. The product is useful in the promotion of cell division (mitogenesis) such as in the promotion of wound healing.