1
Rainer Alex, Paul Hadvary, Hansjorg Tschirky: Dermally affixed injection device. Hoffmann La Roche, George W Johnston, William H Epstein, John P Parise, August 3, 1999: US05931814 (484 worldwide citation)

An improved injection device has a casing containing an active substance reservoir, a cannula communicating with the reservoir, a device for inserting the cannula, and pump means for discharging the reservoir contents through the cannula. The cannula 11 is fixed relative to the casing and projects b ...


2
Giorgio Cirelli, Benno Rothenhausler, Hans Steffen: Device for introducing active substance into a patient. Hoffmann La Roche, George W Johnston, William H Epstein, John P Parise, December 15, 1998: US05848990 (213 worldwide citation)

A device for introducing an active substance solution into a patient and with means for fastening to the skin and a cannula. The cannula is held in a withdrawn position by a retaining and releasing mechanism before use and, after release, is propelled into the patient's skin. A connector connected t ...


3
Robert Karasiewicz, Carlo Nalin, Perry Rosen: Peg-interferon conjugates. Hoffmann La Roche, George M Gould, William H Epstein, Catherine R Roseman, January 17, 1995: US05382657 (204 worldwide citation)

Substituted PEG-interferon conjugates of formulae IA and IB where PEG is linked by means of activated linking reagents of formulae IIA, IIB, or IIB-1 to an amino group in the interferon, and activated linking reagents of formulae IIA, IIB, or IIB-1. The conjugates are not readily susceptible to in v ...


4
Peter Loeliger: Stilbene derivatives. Hoffmann La Roche, Jon S Saxe, George M Gould, William H Epstein, April 20, 1982: US04326055 (177 worldwide citation)

This invention is directed to 5,6,7,8-tetrahydro-naphthyl or indanyl stilbene derivatives which are useful as tumor inhibiting agents, in the treatment of neoplasms, dermatological conditions and rheumatic illnesses.


5
Wilhelm Bannwarth, Francis Muller: Detection of nucleic acids using a hairpin forming oligonucleotide primer and an energy transfer detection system. Hoffmann La Roche, George M Gould, William H Epstein, Patricia S Rocha Tramaloni, November 12, 1996: US05573906 (140 worldwide citation)

A process for the detection of a nucleic acid sequence in a homogeneous assay format using an energy transfer system is disclosed. This process utilizes a 5' labeled primer containing a selfcomplementary sequence in an amplification or extension process together with a subsequent detection step usin ...


6
Rolf Moser, Lukas Birrer: Thermal cycler. Roche Diagnostic Systems, George W Johnston, William H Epstein, John P Parise, August 18, 1998: US05795547 (129 worldwide citation)

An apparatus for automatic performance of temperature cycles in a number of test tubes in which each test tube is closed by a closure and contains a predetermined volume of a liquid reaction mixture. The apparatus includes a holder, a computer-controlled automatic control system, and a device for cy ...


7
John Hakimi, Patricia Kilian, Perry Rosen: Polyethylene-protein conjugates. Hoffmann La Roche, George W Johnston, William H Epstein, Lewis J Kreisler, May 5, 1998: US05747646 (127 worldwide citation)

The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein whic ...


8
John Hakimi, Patricia Kilian, Perry Rosen: Polyethylene-protein conjugates. Hoffman La Roche, George W Johnston, William H Epstein, Lewis J Kreisler, November 10, 1998: US05834594 (120 worldwide citation)

The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immunogenic response possessed by the protein whic ...


9
Hendrik G Stunnenberg, Riccardo Wittek: Vaccinia DNA. Hoffmann La Roche, George M Gould, Bernard S Leon, William H Epstein, May 21, 1991: US05017487 (116 worldwide citation)

New transcriptional regulatory sequences useful in the expression of pro- or eukaryotic proteins in eukaryotic organisms are provided comprising the 5' flanking region of the vaccinia virus late 11 kDa gene. Also described are recombinant vectors and recombinant infectious poxviruses containing such ...


10
Rolf Knobel: Analytical device for separating magnetic microparticles from suspensions. Hoffmann La Roche, George W Johnston, William H Epstein, John P Parise, January 6, 1998: US05705062 (105 worldwide citation)

An analytical device separates magnetic microparticles from a suspension. The separating portion of the device contains two permanent magnets between which the reaction vessel containing the suspension is disposed. For the purpose of more rapid, complete separation of the magnetic microparticles, ma ...