1
Joseph W Saur, Charles P Reynolds, Alfred T Black: Magnetic separation device. The United States of America represented by the Secretary of the Navy, John L Forrest, Wendell R Guffey, Andrew M Lesniak, December 1, 1987: US04710472 (76 worldwide citation)

A magnetic separation device suitable for removing magnetic bead-coated cells from a system comprising a base, a plurality of magnets mounted on the base such that a sample chamber is created for holding sample containers which are to be placed in close proximity to the magnets, and a means for adju ...


2
Randolph B DePrince, Ravi Viswanathan: Stabilized porcine growth hormone. International Minerals & Chemical, Wendell R Guffey, Thomas L Farquer, George R Repper, August 23, 1988: US04765980 (65 worldwide citation)

Porcine serum albumin stabilizes porcine growth hormone, and provided for sustained release of porcine growth hormone in implant devices for swine.


3
Eddie L Chang: Magnetically-localizable, polymerized lipid vesicles and method of disrupting same. The United States of America represented by the Secretary of the Navy, Sol Sheinbein, Wendell R Guffey, March 24, 1987: US04652257 (59 worldwide citation)

Polymerizable lipids are used to encapsulate therapeutic agents and ferronetic particles into lipid vesicles. The vesicles are polymerized, injected into the body upstream of a targeted capillary bed, allowed to flow within the bloodstream to the targeted site, and held there by an externally applie ...


4
Edwin J Hamilton Jr, Bruce D Burleigh: Stabilization of growth hormones. International Minerals & Chemical, Wendell R Guffey, Bruce J Hendricks, Thomas L Farquer, March 28, 1989: US04816568 (50 worldwide citation)

Growth hormones are admixed with various stabilizers to provide for the decreased formation of insolubles and preservation of the soluble bioactivity of the growth hormone in aqueous environments. Examples of such stabilizers include certain polyols, amino acids, polymers of amino acids having a cha ...


5
Kallidaikurichi N Sivaramakrishnan, Lindy F Miller: Controlled release delivery device for macromolecular proteins. Pitman Moore, Wendell R Guffey, William J Fisher, June 15, 1993: US05219572 (41 worldwide citation)

A controlled release delivery device for macromolecular proteins which comprises a water-soluble outer capsule completely surrounding an inner compartment containing a plurality of non-uniform beadlets. The beadlets comprise a rupturable wax shell which completely surrounds a core matrix containing ...


6
Steven K Rausch, Hsi Meng: Purification and activation of proteins from insoluble inclusion bodies. International Minerals & Chemical, George R Repper, Thomas L Farquer, Wendell R Guffey, June 30, 1987: US04677196 (41 worldwide citation)

Purification and activation of proteins produced in transformant microorganisms as insoluble, biologically inactive inclusion bodies can be effected by solubilizing the inclusion bodies in SDS; dialyzing or refrigerating the protein solution to remove a portion of the SDS; chromatographing the prote ...


7
Steven K Rausch: Purification and activation of proteins from insoluble inclusion bodies. International Minerals & Chemical, Wendell R Guffey, Thomas L Farquer, Peter R Shearer, August 23, 1988: US04766224 (38 worldwide citation)

Purification and solubilization of proteins produced in transformant microorganisms as insoluble, biologically inactive inclusion bodies is effected by solubilizing the inclusion bodies in SDS; treating the SDS-protein solution with urea; removing the SDS and purifying the protein by chromatography ...


8
Mohamad D Shalati, Kallidaikurichi N Sivaramakrishnan: Controlled release delivery system for macromolecules. International Minerals & Chemical, Wendell R Guffey, Thomas L Farquer, May 19, 1987: US04666704 (33 worldwide citation)

A controlled release implant composition which includes a core comprising a macromolecular drug and a water insoluble polymer and a homogeneous outer polymeric membrane formed by coating said core with an organic solution of a water insoluble polymer and a water soluble pore-forming agent.


9
James E Seely, Hsi Meng: Growth hormone-releasing factor analogs. Pitman Moore, Wendell R Guffey, Thomas L Farquer, Barbara G Ernst, August 11, 1992: US05137872 (24 worldwide citation)

Human Growth Hormone-Releasing Factor (hGRF) analogs having the sequence [Pro.sup.0, X.sup.15, Y.sup.27 ]-hGRF(1-A)-B, wherein X is selected from the group consisting of Ala and Gly, Y is selected from the group consisting of Ile, Leu, Val, Nle and Met, A has a value from 29-44, and B is NH.sub.2, O ...


10
Vikram P Mehrotra, Ray E Barker: Process for producing high purity fused quartz powder. Pitman Moore, Wendell R Guffey, Thomas L Farquer, April 2, 1991: US05004488 (23 worldwide citation)

High purity fused silica particles are made by heating relatively low density silica flour in a high temperature flame. The silica flour feed rate, flame temperature, and collection zone temperature are adjusted to produce an aggregate of surface-bonded fused silica particles. The aggregate is shape ...