1
Allyn L Golub: Bandage containing attachment post. Key Pharmaceuticals, Wegner & Bretschneider, November 3, 1981: US04297995 (557 worldwide citation)

A bandage is disclosed comprising a lower portion and a matrix. The lower portion has an upper surface, a base plate on the upper surface, and a post extending from the surface of the base plate. The matrix is attached to the lower portion by means of a hole extending through the matrix which fits a ...


2
Yasushi Nakagawa, Takashi Ito: Chemically modified protein with polyethyleneglycol. Takeda Chemical, Wegner & Bretschneider, December 13, 1988: US04791192 (350 worldwide citation)

The chemically modified protein of the present invention has a strong islet-activating activity and is lower in various side effects than non-modified IAP, so that it may be employed as a prevention and therapeutic drug for diabetes.


3
Koichi Takizawa, Satoshi Nakajima, Masato Arai: Enzyme electrode. Omron Tateisi Electronics Co, Wegner & Bretschneider, January 16, 1990: US04894137 (290 worldwide citation)

An enzyme electrode comprising: an insulative base plate; two or more electrodes formed on the surface of the insulative base plate and each having an exposed portion; an insulative protection film to insulate and protect the electrodes excluding at least those exposed portions; and an immobilized e ...


4
Hiroaki Okada, Yasuaki Ogawa, Takatsuka Yashiki: Prolonged release microcapsule and its production. Takeda Chemical, Wegner & Bretschneider, March 24, 1987: US04652441 (257 worldwide citation)

A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not low ...


5
Toshikazu Shiga, Takuji Suzaki: Non-invasive measuring method and apparatus of blood constituents. Omron Tateisi Electronics Co, Wegner & Bretschneider, May 22, 1990: US04927264 (222 worldwide citation)

In order to measure the oxygen saturation in venous blood, a venous blood stream is made time-variant by applying pressure with a peak value of the minimum blood pressure to a proximal portion from a measuring part. Light beams with different wavelengths are transmitted from the measuring part and d ...


6
Marvin A Sackner, Herman Watson: Drug delivery method and inhalation device therefor. Key Pharmaceuticals, Wegner & Bretschneider, November 27, 1984: US04484577 (180 worldwide citation)

A method and an apparatus for administering a drug through a breathing passage for absorption on the mucous tissue of a patient includes introducing an aerosol of the drug into an expanded bag and bidirectional channel for communicating the drug with the breathing passage of the patient and otherwis ...


7
Toru Hasegawa, Motowo Izawa, Seiichi Tanida: Maytansinoids. Takeda Chemical, Wegner & Bretschneider, May 25, 1982: US04331598 (136 worldwide citation)

Novel antibiotic C-15003 PHM, which is produced by cultivating a microorganism belonging to the genus Nocardia and being capable of producing antibiotic C-15003 PHM, and novel C-15003 PHM acylate, which is produced by subjecting C-15003 PHM thus obtained to acylation reaction with an acylating agent ...


8
Kazuo Kigasawa, Hiroaki Shimizu, Toshihiro Hayashi, Kazuo Watabe, Akira Tanizaki, Osamu Koyama, Kikuo Wakisaka, Yasuaki Ogawa: Soft buccal. Grelan Pharmaceutical, Wegner & Bretschneider, February 25, 1986: US04572832 (134 worldwide citation)

A soft buccal containing (1) a medicament to be absorbed through the oral mucosa, (2) a water-soluble protein, (3) a polyhydric alcohol, and (4) a fatty acid ester or/and a carboxyvinyl polymer, has various advantages such as good feeling in use, good retainability within the mouth, slow release, im ...


9
Osamu Miyashita, Hiroshi Akimoto: Dechloromaytansinoids, their pharmaceutical compositions and method of use. Takeda Chemical, Wegner & Bretschneider, March 17, 1981: US04256746 (134 worldwide citation)

Novel dechloromaytansinoids of the formula: ##STR1## wherein R is H or acyl having 1 to 20 carbon atoms, have antimitotic, antitumor and antimicrobial activities.


10
Mitsuko Asai, Motowo Izawa, Seiichi Tanida: Maytansinoids. Takeda Chemical, Wegner & Bretschneider, March 30, 1982: US04322348 (134 worldwide citation)

Novel Antibiotic C-15003PND, which has the formula: ##STR1## wherein R represents hydrogen, --CO--CH.sub.3, --CO--CH.sub.2 --CH.sub.3, ##STR2## is produced by cultivating a microorganism of the genus Nocardia. The Antibiotic C-15003PND wherein R is acetyl, propionyl, isobutyryl or isovaleryl is usef ...