Allyn L Golub: Bandage containing attachment post. Key Pharmaceuticals, Wegner & Bretschneider, November 3, 1981: US04297995 (557 worldwide citation)

A bandage is disclosed comprising a lower portion and a matrix. The lower portion has an upper surface, a base plate on the upper surface, and a post extending from the surface of the base plate. The matrix is attached to the lower portion by means of a hole extending through the matrix which fits a ...

Yasushi Nakagawa, Takashi Ito: Chemically modified protein with polyethyleneglycol. Takeda Chemical, Wegner & Bretschneider, December 13, 1988: US04791192 (350 worldwide citation)

The chemically modified protein of the present invention has a strong islet-activating activity and is lower in various side effects than non-modified IAP, so that it may be employed as a prevention and therapeutic drug for diabetes.

Koichi Takizawa, Satoshi Nakajima, Masato Arai: Enzyme electrode. Omron Tateisi Electronics Co, Wegner & Bretschneider, January 16, 1990: US04894137 (290 worldwide citation)

An enzyme electrode comprising: an insulative base plate; two or more electrodes formed on the surface of the insulative base plate and each having an exposed portion; an insulative protection film to insulate and protect the electrodes excluding at least those exposed portions; and an immobilized e ...

Hiroaki Okada, Yasuaki Ogawa, Takatsuka Yashiki: Prolonged release microcapsule and its production. Takeda Chemical, Wegner & Bretschneider, March 24, 1987: US04652441 (257 worldwide citation)

A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not low ...

Toshikazu Shiga, Takuji Suzaki: Non-invasive measuring method and apparatus of blood constituents. Omron Tateisi Electronics Co, Wegner & Bretschneider, May 22, 1990: US04927264 (222 worldwide citation)

In order to measure the oxygen saturation in venous blood, a venous blood stream is made time-variant by applying pressure with a peak value of the minimum blood pressure to a proximal portion from a measuring part. Light beams with different wavelengths are transmitted from the measuring part and d ...

Marvin A Sackner, Herman Watson: Drug delivery method and inhalation device therefor. Key Pharmaceuticals, Wegner & Bretschneider, November 27, 1984: US04484577 (180 worldwide citation)

A method and an apparatus for administering a drug through a breathing passage for absorption on the mucous tissue of a patient includes introducing an aerosol of the drug into an expanded bag and bidirectional channel for communicating the drug with the breathing passage of the patient and otherwis ...

Toru Hasegawa, Motowo Izawa, Seiichi Tanida: Maytansinoids. Takeda Chemical, Wegner & Bretschneider, May 25, 1982: US04331598 (136 worldwide citation)

Novel antibiotic C-15003 PHM, which is produced by cultivating a microorganism belonging to the genus Nocardia and being capable of producing antibiotic C-15003 PHM, and novel C-15003 PHM acylate, which is produced by subjecting C-15003 PHM thus obtained to acylation reaction with an acylating agent ...

Kazuo Kigasawa, Hiroaki Shimizu, Toshihiro Hayashi, Kazuo Watabe, Akira Tanizaki, Osamu Koyama, Kikuo Wakisaka, Yasuaki Ogawa: Soft buccal. Grelan Pharmaceutical, Wegner & Bretschneider, February 25, 1986: US04572832 (134 worldwide citation)

A soft buccal containing (1) a medicament to be absorbed through the oral mucosa, (2) a water-soluble protein, (3) a polyhydric alcohol, and (4) a fatty acid ester or/and a carboxyvinyl polymer, has various advantages such as good feeling in use, good retainability within the mouth, slow release, im ...

Osamu Miyashita, Hiroshi Akimoto: Dechloromaytansinoids, their pharmaceutical compositions and method of use. Takeda Chemical, Wegner & Bretschneider, March 17, 1981: US04256746 (134 worldwide citation)

Novel dechloromaytansinoids of the formula: ##STR1## wherein R is H or acyl having 1 to 20 carbon atoms, have antimitotic, antitumor and antimicrobial activities.

Mitsuko Asai, Motowo Izawa, Seiichi Tanida: Maytansinoids. Takeda Chemical, Wegner & Bretschneider, March 30, 1982: US04322348 (134 worldwide citation)

Novel Antibiotic C-15003PND, which has the formula: ##STR1## wherein R represents hydrogen, --CO--CH.sub.3, --CO--CH.sub.2 --CH.sub.3, ##STR2## is produced by cultivating a microorganism of the genus Nocardia. The Antibiotic C-15003PND wherein R is acetyl, propionyl, isobutyryl or isovaleryl is usef ...