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Guillemont Jerôme Emile Georges, Paugam Mikaël, Delest Bruno François Marie: Hiv inhibiting 5-amido substituted pyrimidines. Tibotec Pharmaceuticals, Guillemont Jerôme Emile Georges, Paugam Mikaël, Delest Bruno François Marie, WANTE Dirk, October 11, 2007: WO/2007/113254 (47 worldwide citation)

This invention concerns pyrimidine derivatives of formula having HIV (Human Immunodeficiency Virus) replication inhibiting properties, the preparation thereof and pharmaceutical compositions comprising these compounds.


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Guillemont Jerôme Emile Georges, Paugam Mikaël, Delest Bruno François Marie, Heeres Jan, Lewi Paulus Joannes, Janssen Paul Adriaan Jan: Hiv inhibiting bicyclic pyrimidine derivatives. Tibotec Pharmaceuticals, Guillemont Jerôme Emile Georges, Paugam Mikaël, Delest Bruno François Marie, Heeres Jan, Lewi Paulus Joannes, Arts Frank Xavier Jozef Herwig, WANTE Dirk, May 4, 2006: WO/2006/045828 (46 worldwide citation)

HIV replication inhibitors of formula (I) N-oxides, pharmaceutically acceptable addition salts, quaternary amines or stereoisomeric forms thereof, wherein -a1=a2-a3=a4- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -N=CH-N=CH-, -N=CH- CH=N-, -N=N-CH=CH-; -b1=b2-b3=b4- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -N=CH-N=CH-, ...


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Stokbroekx Sigrid Carl Maria, Leys Carina, Swinney Kelly Ann, Wuyts Stijn, Horvath Andras: Polymorphic forms of a macrocyclic inhibitor of hcv. Tibotec Pharmaceuticals, Stokbroekx Sigrid Carl Maria, Leys Carina, Swinney Kelly Ann, Wuyts Stijn, Horvath Andras, WANTE Dirk, August 7, 2008: WO/2008/092954 (40 worldwide citation)

Provided are crystalline forms of the compound of formula (I), which is a macrocyclic inhibitor of HCV, processes for the preparation thereof, and pharmaceutical compositions comprising these crystalline forms.


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Guillemont Jérôme Emile Georges, Mordant Céline Isabelle, Schmitt Benoit Antoine: Hiv inhibiting 5,6-substituted pyrimidines. Tibotec Pharmaceuticals, Guillemont Jérôme Emile Georges, Mordant Céline Isabelle, Schmitt Benoit Antoine, WANTE Dirk, July 10, 2008: WO/2008/080965 (39 worldwide citation)

R1 is hydrogen; aryl; formyl; C1_6alkylcarbonyl; C1_6alkyl; C1_6alkyloxycarbonyl; R2, R3, R7 and R8 are hydrogen; hydroxy; halo; C3-7cycloalkyl; C1_6alkyloxy; carboxyl; C1_6alkyloxycarbonyl; cyano; nitro; amino; mono- or di(C1_6alkyl)amino; polyhaloC1-6alkyl; polyhaloC1-6alkyloxy; -C(=O)R10; C1_6alk ...


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Raboisson Pierre Jean Marie Bernard: Hcv inhibiting macrocyclic phenylcarbamates. Tibotec Pharmaceuticals, Medivir, Raboisson Pierre Jean Marie Bernard, WANTE Dirk, August 14, 2008: WO/2008/096001 (38 worldwide citation)

Compounds of the Formula (I) including a stereoisomer thereof, or an N-oxide, a pharmaceutically acceptable addition salt, or a pharmaceutically acceptable addition solvate thereof;usefulas HCV inhibitors; processes for preparing these compounds as well as pharmaceutical compositions comprising thes ...


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Raboisson Pierre Jean Marie Bernard, de, Kock Herman Augustinus, Mc, Gowan David Craig, Van de, Vreken Wim, Hu Lili, Tahri Abdellah, Vendeville Sandrine Marie Helene: Macrocyclic inhibitors of hepatitis c virus. Tibotec Pharmaceuticals, Raboisson Pierre Jean Marie Bernard, de, Kock Herman Augustinus, Mc, Gowan David Craig, Van de, Vreken Wim, Hu Lili, Tahri Abdellah, Vendeville Sandrine Marie Helene, WANTE Dirk, May 22, 2008: WO/2008/059046 (35 worldwide citation)

Inhibitors of HCV replication of Formula (I) and the salts and stereoisomers thereof, wherein each dashed line (represented by - - - - -) represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is -OR7, -NH-SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also ...


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Guillemont Jérôme Emile Georges, Mordant Céline Isabelle: Hiv inhibiting 6-substituted pyrimidines. Tibotec Pharmaceuticals, Guillemont Jérôme Emile Georges, Mordant Céline Isabelle, WANTE Dirk, July 10, 2008: WO/2008/080964 (34 worldwide citation)

HIV replication inhibitors of formula (I). R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyl; C1-6alkyloxycarbonyl; R2, R3, R6 and R7 are hydrogen; hydroxy; halo; C3-7cycloalkyl; C1-6alkyloxy; carboxyl; C1-6alkyloxycarbonyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-6alky ...


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