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Wirbisky Alan, Quinn Tim, Van Der, Lught Nick, Morken Nate, Johnson Rebecca, Paulsen Kim, Strom Dan, Baldrica Jim: Compact apparatus, compositions and methods for purifying nucleic acids. Qiagen North American Holdings, Wirbisky Alan, Quinn Tim, Van Der, Lught Nick, Morken Nate, Johnson Rebecca, Paulsen Kim, Strom Dan, Baldrica Jim, VIKSNINS Ann S, May 3, 2007: WO/2007/050327 (45 worldwide citation)

The invention relates to apparatus, materials and methods for isolating RNA or DNA from a sample . The apparatus comprises magnetic elevator means for separating magnetic particles. Aspirating and dispensing pipettes are provided, and an automated isolation method involving washing, elution, and lys ...


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Paulson Henry, Miller Victor, Davidson Beverly L, Gouvion Cynthia: Sirna-mediated gene silencing. University Of Iowa Research Foundation, Paulson Henry, Miller Victor, VIKSNINS Ann S, July 15, 2004: WO/2004/058940 (21 worldwide citation)

The present invention is directed to small interfering RNA molecules (sIRNA) targeted against an allele of interest, and methods of using these sIRNA molecules.


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Mccarty John A: Transmucosal drug delivery system. Pharmaceutical Productions, Mccarty John A, VIKSNINS Ann S, September 10, 2004: WO/2004/075877 (21 worldwide citation)

Disclosed are preparations and formulations of high thermodynamic activity lipophilic associations (LA), in which there is pairing between an ionizable pharmaceutical agent and a lipophilic species having ionic characteristics opposite to that of the pharmaceutical agent. Such lipophilic association ...


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Mitchell Ian S, Spencer Keith L, Stengel Peter, Han Yongxin, Kallan Nicholas C, Munson Mark, Vigers Guy P A, Blake James, Piscopio Anthony, Josey John, Miller Scott, Xiao Dengming, Xu Riu, Rao Chang, Wang bin, Bernacki April L: Akt protein kinase inhibitors. Array Biopharma, Mitchell Ian S, Spencer Keith L, Stengel Peter, Han Yongxin, Kallan Nicholas C, Munson Mark, Vigers Guy P A, Blake James, Piscopio Anthony, Josey John, Miller Scott, Xiao Dengming, Xu Riu, Rao Chang, Wang bin, Bernacki April L, VIKSNINS Ann S, June 9, 2005: WO/2005/051304 (21 worldwide citation)

The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the c ...


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Cho Aesop, Kirschberg Thorsten A, Watkins William J, Fardis Maria, Chong Lee S: Inosine monophosphate dehydrogenase inhibitors as phosphonate derivatives. Gilead Sciences, Cho Aesop, Kirschberg Thorsten A, Watkins William J, Fardis Maria, Chong Lee S, VIKSNINS Ann S, May 6, 2005: WO/2005/039552 (19 worldwide citation)

Phosphorus substituted mycophenolate derivatives with anti-cancer, anti-viral, anti-inflammatory and anti-tissue/organ transplant rejection properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit tumor growth, viral growth, inflammation, and ti ...


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Davidson Beverly L, Mas, Monteys Alejandro, Mcbride Jodi L, Boudreau Ryan: Reduction of off-target rna interference toxicity. University Of Iowa Research Foundation, Davidson Beverly L, Mas, Monteys Alejandro, Mcbride Jodi L, Boudreau Ryan, VIKSNINS Ann S, December 11, 2008: WO/2008/150897 (17 worldwide citation)

The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.


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Davidson Beverly L, Harper Scott: Nucleic acid silencing of huntingtons disease gene. University Of Iowa Research Foundation, Davidson Beverly L, Harper Scott, VIKSNINS Ann S, August 10, 2006: WO/2006/083800 (15 worldwide citation)

The present invention is directed to small interfering RNA molecules (siRNA) targeted against a Huntington's Disease gene, and methods of using these siRNA molecules.


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Portoghese Philip S, Roerig Sandra C: Analgesic conjugates. Regents Of The University Of Minnesota, The Board Of Supervisors Of The Louisiana State University And Agricultural And Mechanical College Acting Through The Louisiana, Portoghese Philip S, Roerig Sandra C, VIKSNINS Ann S, July 13, 2006: WO/2006/073396 (11 worldwide citation)

The present invention relates generally to analgesic compounds having a mu opioid receptor agonist linked to a delta opioid receptor antagonist, and to methods for producing analgesia using such compounds. As compared to opioids such as morphine, these compounds can cause less tolerance, physical de ...


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Davidson Beverly L, Xia Haibin, Mao Qinwen: Sirna-mediated gene silencing with viral vectors. University Of Iowa Research Foundation, Davidson Beverly L, Xia Haibin, Mao Qinwen, VIKSNINS Ann S, February 12, 2004: WO/2004/013355 (11 worldwide citation)

The present invention is directed to viral vectors encoding small interfering RNA molecules (siRNA) targeted against a gene of interest, and methods of using these viral vectors.