1
Michael C Pirrung, J Leighton Read, Stephen P A Fodor, Lubert Stryer: Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof. Affymax Technologies, Kenneth J Nussbacher, Kevin R Kaster, Vern Norviel, September 1, 1992: US05143854 (1323 worldwide citation)

Polypeptide arrays can be synthesized on a substrate by attaching photoremovable groups to the surface of a substrate, exposing selected regions of the substrate to light to activate those regions, attaching an amino acid monomer with a photoremovable group to the activated regions, and repeating th ...


2
Stephen P A Fodor, Lubert Stryer, J Leighton Read, Michael C Pirrung: Arrays of materials attached to a substrate. Affymetrix, Vern Norviel, Nancy J DeSantis, Joseph Liebeschuetz, April 28, 1998: US05744305 (827 worldwide citation)

A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reacto ...


3
Stephen P A Fodor, Lubert Stryer, Michael C Pirrung, J Leighton Read: Very large scale immobilized polymer synthesis. Affymax Technologies, Kevin R Kaster, Vern Norviel, June 13, 1995: US05424186 (505 worldwide citation)

A method for synthesizing oligonucleotides on a solid substrate. The method provides for the irradiation of a first predefined region of the substrate without irradiation of a first predefined region of the substrate. The irradiation of a second predefined region of the substrate. The irradiation st ...


4
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin: Very large scale immobilized polymer synthesis using mechanically directed flow paths. Affymax Technologies, Kevin R Kaster, Vern Norviel, January 24, 1995: US05384261 (374 worldwide citation)

A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are flowed through the channels, the substrate is rotated by a rotatin ...


5
Michael C Pirrung, J Leighton Read, Stephen P A Fodor, Lubert Stryer: Large scale photolithographic solid phase synthesis of an array of polymers. Affymax Technologies, Kevin R Kaster, Vern Norviel, April 11, 1995: US05405783 (297 worldwide citation)

A technique for the synthesis of arrays of diverse polymers such as polypeptides and nucleic acids. The technique beneficially utilizes solid-phase chemistry techniques. Preferred embodiments utilize photolabile protecting groups, and photolithography. The technique forms polymers with monomer seque ...


6
William J Dower, Ronald W Barrett, Mark A Gallop, Michael C Needels: Synthesizing and screening molecular diversity. Affymax Technologies, Kevin Kaster, Vern Norviel, Lauren L Stevens, June 17, 1997: US05639603 (274 worldwide citation)

A general stochastic method for synthesizing compounds can be used to generate large collections of tagged compounds that can be screened to identify and isolate compounds with useful properties.


7
Stephen P A Fodor, Laura T Mazzola: Method and apparatus for measuring binding affinity. Affymax Technologies, Vern Norviel, Kevin Kaster, Joe Liebeschuetz, June 28, 1994: US05324633 (254 worldwide citation)

A method and device for measuring the binding affinity of a receptor to a ligand. According to one aspect of the invention, arrays of polymers are synthesized or immobilized on a substrate (212). The array of polymers is exposed to a fluorescently-labelled receptor in solutions of varying concentrat ...


8
David C Bliven, Anthony Vranicar, Philip B Vail, Gerald L Shimirak, Julian S Mullaney: Alarm and test system for a digital added main line. Raychem Corporation, Vern Norviel, Herbert G Burkard, A Stephen Zavell, May 5, 1992: US05111497 (154 worldwide citation)

A test system directed to apparatus for transmitting and receiving multiple telephone transmission signals over a single twisted pair. The system converts an analog signal from a local switching station to an 80 ksymbols/sec signal for transmission over a twisted pair by a line card. A remote termin ...


9
Stephen P A Fodor, J Leighton Read, Lubert Stryer, Michael C Pirrung: Nucleic acid reading and analysis system. Affymetrix, Vern Norviel, Philip L McGarrigle, June 11, 2002: US06403957 (150 worldwide citation)

A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group; i ...


10
David A Campbell: Chiral synthesis of alpha-aminophosponic acids. Affymax Technologies, Kevin R Kaster, Vern Norviel, Lauren L Stevens, November 8, 1994: US05362899 (76 worldwide citation)

A stereospecific method of preparing alpha-aminophosphonic acids and derivatives thereof is provided. A protected amino acid is converted to a acyl aroyl or diacyl peroxide which spontaneously rearranges to form an alpha-amino ester. This rearrangement occurs stereospecifically with retention of con ...



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