1
Nils Lonberg, Robert M Kay: Transgenic non-human animals capable of producing heterologous antibodies of various isotypes. GenPharm International, Tracy J Dunn, William M Smith, October 29, 1996: US05569825 (951 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies of multiple isotypes. Heterologous antibodies are encoded by immunoglobulin heavy chain genes not normally found in the genome of that species of non-human animal. In one aspect of the invention, one o ...


2
Russell N Van Gelder, Mark E Von Zastrow, Jack D Barchas, James H Eberwine: Process for amplifying a target polynucleotide sequence using a single primer-promoter complex. Tracy J Dunn, August 13, 1996: US05545522 (183 worldwide citation)

This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is synthesized from a ribonucleic acid (RNA) sequence using a complementary primer linked to an RNA polymerase ...


3
Ronald W Barrett, Michael C Pirrung, Lubert Stryer, Christopher P Holmes, Steven A Sundberg: Spatially-addressable immobilization of anti-ligands on surfaces. Affymax Technologies, Kevin R Kaster, Tracy J Dunn, Lauren L Stevens, January 9, 1996: US05482867 (150 worldwide citation)

Methods and compositions are described for immobilizing anti-ligands, such as antibodies or antigens, hormones or hormone receptors, oligonucleotides, and polysaccharides on surfaces of solid substrates for various uses. The methods provide surfaces covered with caged binding members which comprise ...


4
Larry C Mattheakis, William J Dower: In vitro peptide and antibody display libraries. Affymax Technologies, Lauren L Stevens, Tracy J Dunn, July 13, 1999: US05922545 (103 worldwide citation)

Improved methods and novel compositions for identifying peptides and single-chain antibodies that bind to predetermined receptors or epitopes. Such peptides and antibodies are identified by improved and novel methods for affinity screening of polysomes displaying nascent peptides.


5
Stanley J Korsmeyer: Bcl-x/Bcl-2 associated cell death regulator. Washington University, Tracy J Dunn, April 22, 1997: US05622852 (41 worldwide citation)

The invention provides a bcl-2 related protein, Bad, Bad muteins, two-hybrid systems comprising interacting Bad polypeptide sequences, Bad polynucleotides, and uses thereof.


6
Bernard Malfroy Camine, Michel Baudry: Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease. Eukarion, Tracy J Dunn, April 4, 1995: US05403834 (40 worldwide citation)

The invention provides antioxidant salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide.


7
Markus F Renschler, Ronald Levy, Ramesh R Bhatt, William J Dower: Receptor-binding antiproliferative peptides. Tracy J Dunn, April 30, 1996: US05512435 (14 worldwide citation)

Methods and composition are provided for identifying antiproliferative polypeptides which inhibit clonal expansion and/or induce apoptosis in cells of a predetermined cell population (e.g., a neoplastic cell sample) expressing a cell surface receptor which is a member of the immunoglobulin superfami ...


8
Stanley J Korsmeyer: Cell death regulator. Washington University, Tracy J Dunn, December 23, 1997: US05700638 (3 worldwide citation)

The invention provides a bcl-2 related protein, bcl-2 muteins, and uses thereof.


9
Robert J Debs: Methods and compositions for nonviral gene delivery. Tracy J Dunn IP, May 30, 2002: US20020065213-A1

Methods and compositions are described for the efficient delivery and expression of recombinant polynucleotides in animal cells in vitro or in vivo. In particular, a comprehensive approach of non-viral gene delivery is provided that has been optimized with regards to the vectors delivered, maximizin ...