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Richard A Hedges, David L Shockley, Stanley C Fralick, Paul H Kane: Remote gaming system. Townsend & Townsend, August 21, 1984: US04467424 (519 worldwide citation)

A remote gaming system for use with a wagering or gambling establishment such as a casino to enable a player's participation in a selected one of a plurality of wagering games from a remote location. The system includes a croupier station, a credit station and a player station remotely located from ...


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Michael R Harrison, Russell W Jennings, Alan W Flake: Method for performing a gastric wrap of the esophagus for use in the treatment of esophageal reflux. The Regents of the University of California, Townsend & Townsend Khourie & Crew, April 4, 1995: US05403326 (510 worldwide citation)

The invention provides a method of fundoplication of the stomach to the esophagus comprising introducing an esophageal manipulator (72) into the stomach lumen (10), maneuvering the manipulator within the lumen so as to create an intussusception (48) of the esophagus (14) into the stomach, introducin ...


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Willem P C Stemmer: Methods for in vitro recombination. Affymax Technologies, Townsend & Townsend & Crew, February 25, 1997: US05605793 (496 worldwide citation)

A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present inve ...


15
Jeremy Minshull, Willem P C Stemmer: Methods and compositions for cellular and metabolic engineering. Maxygen, Townsend & Townsend & Crew, November 17, 1998: US05837458 (493 worldwide citation)

The present invention is generally directed to the evolution of new metabolic pathways and the enhancement of bioprocessing through a process herein termed recursive sequence recombination. Recursive sequence recombination entails performing iterative cycles of recombination and screening or selecti ...


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Willem P C Stemmer, Andreas Crameri: Methods for generating polynucleotides having desired characteristics by iterative selection and recombination. Affymax Technologies, Townsend & Townsend & Crew, September 22, 1998: US05811238 (490 worldwide citation)

A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The p ...


17
William J Dower, Steven E Cwirla: Recombinant library screening methods. Affymax Technologies, Townsend & Townsend & Crew, December 3, 1996: US05580717 (489 worldwide citation)

Nucleotide sequences encoding proteins of interest are isolated from DNA libraries using bacteriophage to link the protein to the sequence which encodes it. DNA libraries are prepared from cells encoding the protein of interest and inserted into or adjacent to a coat protein of a bacteriophage vecto ...


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Willem P C Stemmer, Andreas Crameri: DNA mutagenesis by random fragmentation and reassembly. Affymax Technologies, Townsend & Townsend & Crew, November 3, 1998: US05830721 (477 worldwide citation)

A method for generating libraries of displayed peptides and/or antibodies (Abs) suitable for affinity interaction screening or phenotypic screening comprising: (i) obtaining selected library members comprising a displayed peptide and/or Ab and the corressponding polynucleotide (PN), or copies of it, ...


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Mark Trulson, David Stern, Peter Fiekowsky, Richard Rava, Ian Walton, Stephen P A Fodor: Method and apparatus for imaging a sample on a device. Affymetrix, Townsend & Townsend & Crew, November 26, 1996: US05578832 (457 worldwide citation)

The present invention provides methods and systems for detecting a labeled marker on a sample located on a support. The imaging system comprises a body for immobilizing the support, an excitation radiation source and excitation optics to generate and direct the excitation radiation at the sample. In ...