1
Tarran Jones
Mary M Bendig, Olivier J Leger, Jose Saldanha, S Tarran Jones, Ted A Yednock: Humanized antibodies against leukocyte adhesion molecule VLA-4. Athena Neurosciences, Townsend & Townsend & Crew, November 24, 1998: US05840299 (82 worldwide citation)

The invention provides humanized immunoglobulins that specifically bind to the VLA-4 ligand, and methods of treatment using the same. The methods are particularly useful for treatment of multiple sclerosis.


2
Cary L Queen, Man Sung Co, William P Schneider, Nicholas F Landolfi, Kathleen L Coelingh, Harold E Selick: Humanized immunoglobulins. Protein Design Labs, Townsend & Townsend & Crew, December 2, 1997: US05693762 (1131 worldwide citation)

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immuno ...


3
Nils Lonberg, Robert M Kay: Ransgenic non-human animals for producing heterologous antibodies. GenPharm International, Townsend & Townsend & Crew, August 13, 1996: US05545806 (997 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppressed by antisense polynucleotides and/or b ...


4
Robert P Barrie, Jon Bengtson: Multiple progressive gaming system that freezes payouts at start of game. IGT, Townsend & Townsend, June 6, 1989: US04837728 (732 worldwide citation)

A rapidly incrementing multiple progressive gaming system. One or more gaming controllers are coupled to a progressive controller. Coin drop and win information at each gaming controller is provided to and accumulated by the progressive controller. Meter amounts generated at the progressive controll ...


5
Stephen C Anderson, Christopher A Julian: Robotic surgical tool with ultrasound cauterizing and cutting instrument. Intuitive Surgical, Nathan S Cassell Esq, Townsend&Townsend&CrewLLP, August 31, 2004: US06783524 (721 worldwide citation)

A surgical instrument for enhancing robotic surgery generally includes an elongate shaft with an ultrasound probe, an end effector at the distal end of the shaft, and a base at the proximal end of the shaft. The end effector includes an ultrasound probe tip and the surgical instrument is generally c ...


6
James A Baker, Csaba Truckai, John H Shadduck: Electrosurgical instrument. SurgRx, Townsend & Townsend & Crew, August 9, 2005: US06926716 (624 worldwide citation)

A working end of a surgical instrument that carries first and second jaws for delivering energy to tissue. In a preferred embodiment, at least one jaw of the working end defines a tissue-engagement plane that contacts the targeted tissue. The cross-section of the engagement plane reveals that it def ...


7
Greg R Patterson, G Ronald Williams, James J Leary: Apparatus and method for controlled removal of stenotic material from stents. Prolifix Medical, Townsend&Townsend&Crew, August 24, 1999: US05941869 (616 worldwide citation)

Apparatus and methods for treating in-stent restenosis are described for removing stenotic material from within previously stented regions of a patient's vasculature. The apparatus includes a catheter system having a stenotic material removal mechanism mounted on a distal portion of an elongated inn ...


8
Rolfe C Anderson, Robert J Lipshutz, Richard P Rava, Stephen P A Fodor: Integrated nucleic acid diagnostic device. Affymetrix, Townsend & Townsend & Crew, July 13, 1999: US05922591 (592 worldwide citation)

The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the d ...


9
Gunter D Niemeyer, William C Nowlin, Gary S Guthart: Alignment of master and slave in a minimally invasive surgical apparatus. Intuitive Surgical, Mark D Barrish Esq, Townsend Townsend & Crew, April 2, 2002: US06364888 (534 worldwide citation)

This invention relates to establishing alignment or a desired orientational relationship between a master and a slave of a telerobotic system. The invention can advantageously be used in a surgical apparatus. A method of establishing a desired orientational relationship between a hand-held part of a ...


10
Michael R Harrison, Russell W Jennings, Alan W Flake: Method for performing a gastric wrap of the esophagus for use in the treatment of esophageal reflux. The Regents of the University of California, Townsend & Townsend Khourie & Crew, April 4, 1995: US05403326 (490 worldwide citation)

The invention provides a method of fundoplication of the stomach to the esophagus comprising introducing an esophageal manipulator (72) into the stomach lumen (10), maneuvering the manipulator within the lumen so as to create an intussusception (48) of the esophagus (14) into the stomach, introducin ...



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