Tarran Jones
Mary M Bendig, Olivier J Leger, Jose Saldanha, S Tarran Jones, Ted A Yednock: Humanized antibodies against leukocyte adhesion molecule VLA-4. Athena Neurosciences, Townsend & Townsend & Crew, November 24, 1998: US05840299 (86 worldwide citation)

The invention provides humanized immunoglobulins that specifically bind to the VLA-4 ligand, and methods of treatment using the same. The methods are particularly useful for treatment of multiple sclerosis.

Cary L Queen, Man Sung Co, William P Schneider, Nicholas F Landolfi, Kathleen L Coelingh, Harold E Selick: Humanized immunoglobulins. Protein Design Labs, Townsend & Townsend & Crew, December 2, 1997: US05693762 (1170 worldwide citation)

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immuno ...

Nils Lonberg, Robert M Kay: Ransgenic non-human animals for producing heterologous antibodies. GenPharm International, Townsend & Townsend & Crew, August 13, 1996: US05545806 (1042 worldwide citation)

The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppressed by antisense polynucleotides and/or b ...

James A Baker, Csaba Truckai, John H Shadduck: Electrosurgical instrument. SurgRx, Townsend & Townsend & Crew, August 9, 2005: US06926716 (679 worldwide citation)

A working end of a surgical instrument that carries first and second jaws for delivering energy to tissue. In a preferred embodiment, at least one jaw of the working end defines a tissue-engagement plane that contacts the targeted tissue. The cross-section of the engagement plane reveals that it def ...

Greg R Patterson, G Ronald Williams, James J Leary: Apparatus and method for controlled removal of stenotic material from stents. Prolifix Medical, Townsend&Townsend&Crew, August 24, 1999: US05941869 (639 worldwide citation)

Apparatus and methods for treating in-stent restenosis are described for removing stenotic material from within previously stented regions of a patient's vasculature. The apparatus includes a catheter system having a stenotic material removal mechanism mounted on a distal portion of an elongated inn ...

Rolfe C Anderson, Robert J Lipshutz, Richard P Rava, Stephen P A Fodor: Integrated nucleic acid diagnostic device. Affymetrix, Townsend & Townsend & Crew, July 13, 1999: US05922591 (628 worldwide citation)

The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the d ...

Gunter D Niemeyer, William C Nowlin, Gary S Guthart: Alignment of master and slave in a minimally invasive surgical apparatus. Intuitive Surgical, Mark D Barrish Esq, Townsend Townsend & Crew, April 2, 2002: US06364888 (584 worldwide citation)

This invention relates to establishing alignment or a desired orientational relationship between a master and a slave of a telerobotic system. The invention can advantageously be used in a surgical apparatus. A method of establishing a desired orientational relationship between a hand-held part of a ...

Michael J Tierney, Thomas Cooper, Chris Julian, Stephen J Blumenkranz, Gary S Guthart, Robert G Younge: Mechanical actuator interface system for robotic surgical tools. Intuitive Surgical, Scott M Smith Esq, Townsend Townsend & Crew, December 10, 2002: US06491701 (515 worldwide citation)

Robotic surgical tools, systems, and methods for preparing for and performing robotic surgery include a memory mounted on the tool. The memory can perform a number of functions when the tool is loaded on the tool manipulator: first, the memory can provide a signal verifying that the tool is compatib ...

Jeremy Minshull, Willem P C Stemmer: Methods and compositions for cellular and metabolic engineering. Maxygen, Townsend & Townsend & Crew, November 17, 1998: US05837458 (489 worldwide citation)

The present invention is generally directed to the evolution of new metabolic pathways and the enhancement of bioprocessing through a process herein termed recursive sequence recombination. Recursive sequence recombination entails performing iterative cycles of recombination and screening or selecti ...

Willem P C Stemmer: Methods for in vitro recombination. Affymax Technologies, Townsend & Townsend & Crew, February 25, 1997: US05605793 (486 worldwide citation)

A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present inve ...