61
Robin D Clark, Richard M Eglen, Joseph M Muchowski, William L Smith, Klaus K Weinhardt: Serotonergic alpha-oxoacetamides. Syntex, Wayne W Montgomery, Derek P Freyberg, Tom M Moran, March 9, 1993: US05192770 (28 worldwide citation)

.alpha.-Oxoacetamides of the formula R.sup.1 C(O)C(O)NR.sup.2 R.sup.3 in which R.sup.1 is optionally substituted phenyl, 1-indolyl, 2,3-dihydro-1-indolyl, 1-benzimidazolidinonyl, 3-benzofuranyl, 3-benzothiophenyl, 3-indolyl, and 1,2-alkano-3-indolyl; R.sup.2 is selected from: ##STR1## and R.sup.3 is ...


62
Subramaniam Shastri, Zafaruzzaman I Shaikh: Propylene carbonate ointment vehicle. Syntex Corporation, Tom M Moran, Joseph I Hirsch, April 12, 1977: US04017615 (28 worldwide citation)

An ointment vehicle containing from 0.5 to 30 percent propylene carbonate, from 30 to 99.5 weight percent petrolatum and/or polysiloxane, compatible cosolvent, the concentration of which in combination with propylene carbonate is from 0.5 to 70 percent, and, optionally, surfactants, thickeners, pres ...


63
Francisco S Alvarez: 17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes. Syntex, Tom M Moran, Gerard A Blaufarb, April 15, 1980: US04198403 (28 worldwide citation)

Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters substituted at the 4-position with a fluoro, chloro or bromo and optionally substituted at the six position with fluoro or chloro are useful as anti-inflammatory steroids. These compounds are optionally substit ...


64
Anthony C Allison, Noelene E Byars: Vaccines comprising polyoxypropylene-polyoxyethylene block polymer based adjuvants. Syntex, Carol J Roth, Tom M Moran, Derek P Freyberg, September 20, 1988: US04772466 (27 worldwide citation)

A vaccine contains an immunologically effective amount of an antigen, a polyoxypropylene-polyoxyethylene block polymer, a glycol ether-based surfactant, an immunopotentiating amount of an immunostimulating glycopeptide, and, optionally, a metabolizable non-toxic oil.


65
John J Nestor Jr, Brian H Vickery: Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists. Syntex, Liza K Toth, Tom M Moran, Alan M Krubiner, January 31, 1989: US04801577 (27 worldwide citation)

Synthetic nona- and decapeptide LHRH antagonist analogs are disclosed, having a sterically hindered guanidino-substituted arginyl or homoarginyl residue at position 8, with no arginyl substituent at position 6.


66
John J Nestor, Brian H Vickery: Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist. Syntex, Charles L Hartman, Tom M Moran, Alan M Krubiner, July 23, 1985: US04530920 (27 worldwide citation)

Synthetic nonapeptide and decapeptide LHRH agonists analogs having a novel gaunadino-substituted, amidine, tertiary or quatrinary aminoacyl residue at position 6 are disclosed herein.


67
John A Edwards: Thioetianic acid derivatives. Syntex, Tom M Moran, Gerard A Blaufarb, February 12, 1980: US04188385 (27 worldwide citation)

Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters are useful as antiinflammatory steroids. These compounds are optionally substituted at the 6 alpha-position with fluoro, or chloro; optionally substituted at the 9 alpha position with fluoro, chloro or bromo; s ...


68
John A Edwards: Thio etianic acid derivatives. Syntex, Tom M Moran, Alan M Krubiner, April 21, 1981: US04263289 (27 worldwide citation)

Certain 16.beta.-methyl-3-oxoandrost-4-ene and 16.beta.-methyl-3-oxoandrosta-1,4-diene 17.beta.-thiocarboxylic acid esters are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 6.alpha.-position with fluoro or chloro; optionally substituted at the 9.alpha. posit ...


69
Peter H Nelson: Arachidonic acid analogues as anti-inflammatory and anti-allergic agents. Syntex, Alan M Krubiner, Tom M Moran, Charles L Hartman, February 5, 1985: US04497827 (26 worldwide citation)

Novel compounds of this invention are tetrazole, acylhydroxylamine, hydroxymethylketone and amide derivatives of unsaturated fatty acids which are selective inhibitors of the enzymes lipoxygenase and cyclooxygenase involved in the production of pain, inflammation, bronchoconstriction and allergic re ...


70
Julien P H Verheyden, John C Martin: Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent. Syntex, James J Wong, David A Lowin, Tom M Moran, October 5, 1993: US05250535 (26 worldwide citation)

Compounds useful as antiviral agents are defined by the following formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is hydrogen or --C(O)R.sup.7 wherein R.sup.7 is hydrogen, alkyl of one to nineteen carbon atoms, hydroxyalkyl of one to eight carbon ato ...