41
Calum B MacFarlane, Alastair B Selkirk, Michael J Dey: Method of preparing long acting formulation. Syntex, Lester E Johnson, Tom M Moran, Alan M Krubiner, July 10, 1990: US04940556 (38 worldwide citation)

A long acting sustained release pharmaceutical composition for dihydropyridine calcium channel blockers wherein the calcium channel blocker and a pH-dependent binde are intimately admixed in essentially spherically shaped non-rugose particles of up to 1.2 mm in diameter.


42
Deborah A Eppstein, Elizabeth Fraser Smith, Thomas R Matthews: Method for enhancing the anti-infective activity of muramyldipeptide derivatives. Syntex, Grant D Green, Tom M Moran, Alan M Krubiner, August 4, 1987: US04684625 (38 worldwide citation)

Co-administration of a muramyldipeptide derivative with liposomes enhances the anti-infective activity of the muramyldipeptide derivative.


43
M Rene Malinow: Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis. Medical Research Foundation of Oregon, Ellen J Buckles, Tom M Moran, Alan M Krubiner, July 22, 1986: US04602005 (37 worldwide citation)

This invention discloses novel glycosides which are potent inhibitors of cholesterol absorption and therefore useful in treating hypercholesterolemia and atherosclerosis. Particularly useful in this respect is glycoside tigogenin cellobioside. The method of use for treatment of hypercholesterolemia ...


44
Brian H Vickery: Dromostanolone propionate implant pellet useful for producing weight gains in animals and suppressing estrus in female animals. Syntex Corporation, Tom M Moran, November 16, 1976: US03991750 (36 worldwide citation)

Dromostanolone propionate has been found to result in a surprisingly large increase in weight in animals when administered as a pellet implant. In female animals, e.g. heifers, estrus is also suppressed. A particularly effective implant pellet exhibits a substantially constant rate of drug delivery ...


45
Robin D Clark: 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones. Syntex, Annette M Moore, Tom M Moran, October 12, 1982: US04353900 (36 worldwide citation)

Compounds useful in the prevention and/or treatment of hypertension, congestive heart failure, arrhythmia, migraine, vasospastic disorders, and asthma are represented by the formula ##STR1## wherein: R.sup.1 is ##STR2## wherein X is hydrogen, lower alkyl, lower alkoxy, halo, carboxamido or hydroxy; ...


46
Robin D Clark: 9-(1,4-Benzodioxan-2-ylalkyl and hydroxyalkyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-ones. Syntex, Annette M Moore, Tom M Moran, October 12, 1982: US04353901 (35 worldwide citation)

Compounds useful in the prevention and/or treatment of hypertension, congestive heart failure, arrhythmia, migraine, vasospastic disorders, and asthma are represented by the formula: ##STR1## wherein:


47
Martin Katz, John S Kent: Inert core implant pellet. Syntex Corporation, Tom M Moran, Joseph I Hirsch, December 25, 1979: US04180560 (35 worldwide citation)

A novel spherical implant pellet containing estradiol, estradiol benzoate, or mixtures thereof as the sole active ingredients which exhibits a substantially constant drug release rate over a timer period and substantially abrupt termination of drug release at the end of the time period is prepared w ...


48
Calum B MacFarlane, Alastair B Selkirk, Michael J Dey: Long acting nicardipine hydrochloride formulation. Syntex, David A Lowin, Tom M Moran, Cathleen M Desjardins, March 30, 1993: US05198226 (34 worldwide citation)

A long acting sustained release pharmaceutical composition for dihydropyridine calcium channel blockers wherein the calcium channel blocker and a pH-dependent binder are intimately admixed in essentially spherically shaped non-rugose particles of up to 1.2 mm in diameter.


49
Julien P H Verheyden, John C Martin, G V Bindu Madhaven, Daniel P C McGee, Ernest J Prisbe: Purinyl or pyrimidinyl substituted hydroxycyclopentane compounds useful as antivirals. Syntex, Annette M Moore, Tom M Moran, August 12, 1986: US04605659 (33 worldwide citation)

Novel 4-substituted-5-hydroxymethyl-1,2-cyclopentanediols or 1-cyclopentanol substituted at the 3-position by various heterocyclic groups are useful as antiviral agents.


50
Gordon J Dow, Robert W Lathrop, Debra A Dow: Topical gel delivery system. Dow Pharmaceutical Sciences, Tom M Moran, Cooley Godward, February 11, 2003: US06517847 (33 worldwide citation)

A composition is provided that has a viscosity of less than about 15,000 cP and a pH of about 3.0 to 9.0 for treating a skin disorder in a human subject. The composition is a lotion that consists essentially of (a) a therapeutically-effective amount of at least one compound useful for treating such ...