31
Anthony C Allison, Noelene E Byars: Polyoxypropylene-polyoxyethylene block polymer based adjuvants. Syntex, Grant D Green, Tom M Moran, Alan M Krubiner, August 19, 1986: US04606918 (49 worldwide citation)

A method for enhancing the immunogenicity of an antigen is emulsifying it with a polyoxypropylene-polyoxyethylene block polymer, a glycol ether-based surfactant, a metabolizable non-toxic oil, isoosmotic saline, and an immunopotentiating amount of an immunostimulating glycopeptide.


32
Keith A M Walker: Syntex, Annette M Moore, Tom M Moran, June 11, 1985: US04522948 (48 worldwide citation)

New compounds of the formula ##STR1## wherein: R.sup.1 is cycloalkyl of five to seven carbon atoms optionally substituted with one or more lower alkyl groups;


33
Cherng Chyi Fu: Contact lens cleaning, storing and wetting solutions. Syntex, James M Kanagy, Tom M Moran, Alan M Krubiner, April 6, 1982: US04323467 (46 worldwide citation)

A solution for cleaning, storing or wetting contact lenses which comprises a poly(oxyethylene)-poly(oxypropylene) substituted ethylenediamine surfactant having a molecular weight between 1,600 and 27,000; a germicidal agent; a viscosity builder; a tonicity agent; a sequestering agent and water.


34
Keith A M Walker, John J Bruno, Gregory R Martinez: Carbostyril derivatives as combined thromboxane synthetase and cyclic-amp phosphodiesterase inhibitors. Syntex, Brian Lewis, Tom M Moran, Alan M Krubiner, May 1, 1990: US04921862 (45 worldwide citation)

The invention concerns a method of inhibiting both thromboxane synthetase and cyclic-AMP phosphodiesterase in a mammal having a disease characterized by elevated thromboxane levels or an imbalance of prostacyclin/thromboxane levels with a compound of the formula: ##STR1## or a pharmaceutically accep ...


35
Peter H Nelson, Chee Liang L Gu, Anthony C Allison, Elsie M Eugui, William A Lee: Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions. Syntex, David A Lowin, Tom M Moran, June 28, 1988: US04753935 (44 worldwide citation)

The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or --C(O)R, where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, anti-inflammatory agents, anti-tumor agents, anti-viral agents, and anti-psoriatic ...


36
Boyd J Poulsen: Pharmaceutical composition. Syntex, Tom M Moran, January 20, 1976: US03934013 (42 worldwide citation)

This invention relates to a topical, anti-inflammatory, pharmaceutical composition which comprises (a) a pharmaceutically acceptable solvent, e.g. propylene glycol and water, and (b) at least two corticosteroids chosen from those represented by formulas A through K defined hereinafter, each corticos ...


37
Charles H Hsiao, John S Kent: Controlled release naproxen and naproxen sodium tablets. Syntex, Ellen J Wise, Tom M Moran, Alan M Krubiner, February 7, 1989: US04803079 (41 worldwide citation)

A controlled release tablet for once-daily oral administration of about 500-1200 mg of naproxen or naproxen sodium, said tablet comprising a homogeneous matrix comprising about 4-9 weight percent of hydroxypropyl methylcellulose having a number average molecular weight in the range of from about 80, ...


38
Richard A Edgren: Method of contraception using peak progestogen dosage. Syntex Pharmaceuticals International, Tom M Moran, Alan M Krubiner, June 28, 1983: US04390531 (41 worldwide citation)

A method of contraception and a pharmaceutical package for effecting the method are disclosed. The method comprises a three phase sequence of estrogen/progestogen administration which is a daily sequence of unit dosages over a repeating cycle, which dosage sequence comprises, for one cycle:


39
Arthur F Kluge, Arthur M Strosberg, Stefan H Unger: 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof. Syntex, Tom M Moran, Alan M Krubiner, March 10, 1981: US04255432 (40 worldwide citation)

Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are the same or different and are hydrogen, C.sub.1 to C.sub.6 alkyl, C.sub.6 to C.sub.12 carbocyclic aryl or aralkyl of 1 to 6 carbon atoms in the alkyl moiety and 6 to 12 carbon atoms in the carbocyclic aryl moiety;


40
Charles H Hsiao, John S Kent: Controlled release naproxen and naproxen sodium tablets. Syntex, Ellen J Buckles, Tom M Moran, Alan M Krubiner, February 18, 1986: US04571333 (39 worldwide citation)

A controlled release tablet for once-daily oral administration of about 500-1200 mg of naproxen or naproxen sodium, said tablet being a homogeneous matrix comprising about 4-9 weight percent of hydroxypropylmethylcellulose having a number average molecular weight in the range of from about 80,000 to ...